CLDN17

Functionⁱ

Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability.1 Publication

GO - Molecular functionⁱ

chloride channel activity Source: UniProtKB-KW
identical protein binding Source: UniProtKB
structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chloride channel, Ion channel
Biological process	Ion transport, Transport
Ligand	Chloride

Enzyme and pathway databases

Reactomeⁱ	R-HSA-420029 Tight junction interactions

Reactomeⁱ

R-HSA-420029 Tight junction interactions

Protein family/group databases

TCDBⁱ	1.H.1.1.13 the claudin tight junction (claudin1) family

TCDBⁱ

1.H.1.1.13 the claudin tight junction (claudin1) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Claudin-17
Gene namesⁱ	Name:CLDN17 ORF Names:UNQ758/PRO1489
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 21

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000156282.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2038 CLDN17
MIMⁱ	617005 gene
neXtProtⁱ	NX_P56750

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 7	CytoplasmicSequence analysis	7
Transmembraneⁱ	8 – 28	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	29 – 81	ExtracellularSequence analysisAdd BLAST	53
Transmembraneⁱ	82 – 102	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	103 – 124	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	125 – 145	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	146 – 164	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	165 – 185	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	186 – 224	CytoplasmicSequence analysisAdd BLAST	39

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	31	R → E: Decreased transepithelial resistance and anion selectivity. Higher permeability to chloride, sodium and also to larger anions, including pyruvate, nitrate, and thiocyanate. 1 Publication	1
Mutagenesisⁱ	44	E → A: Decreased transepithelial resistance and anion selectivity. 1 Publication	1
Mutagenesisⁱ	45	R → A: Decreased transepithelial resistance, no effect on anion selectivity. 1 Publication	1
Mutagenesisⁱ	48	E → K or Q: Decreased transepithelial resistance and anion selectivity. Higher permeability to chloride, sodium and also to larger anions, including pyruvate, nitrate, and thiocyanate. 1 Publication	1
Mutagenesisⁱ	56	R → A: No effect on transepithelial resistance, nor on anion selectivity. Elevated permeabilities not only for chloride, but also for sodium and the larger anions, including pyruvate, nitrate and thiocyanate. 1 Publication	1
Mutagenesisⁱ	56	R → T: Decreased anion selectivity. Increased permeabilities not only for chloride, but also for sodium and thiocyanate. No effect on transepithelial resistance. 1 Publication	1
Mutagenesisⁱ	59	R → A: No effect on transepithelial resistance, nor on anion selectivity. Increased permeability for thiocyanate. 1 Publication	1
Mutagenesisⁱ	61	R → A: Decreased anion selectivity. No effect on transepithelial resistance. 1 Publication	1
Mutagenesisⁱ	65	K → A: Reduced channel formation ability. Increased transepithelial resistance. Loss of anion selectivity in favor of cation selectivity. 1 Publication	1
Mutagenesisⁱ	65	K → E: No effect on channel formation ability. Loss of anion selectivity in favor of cation selectivity. No effect on transepithelial resistance. 1 Publication	1
Mutagenesisⁱ	65	K → R: Strongly reduced channel formation ability. Increased transepithelial resistance. Loss of anion selectivity in favor of cation selectivity. 1 Publication	1
Mutagenesisⁱ	68	S → E: Increased transepithelial resistance. Loss of anion selectivity in favor of cation (sodium) selectivity. 1 Publication	1
Mutagenesisⁱ	149	Y → A: Increased transepithelial resistance. No effect on localization to cell-cell junctions. 1 Publication	1
Mutagenesisⁱ	154	H → A: Loss of anion selectivity. Strongly increased permeabilities not only for chloride, but also for sodium and the larger anions, including pyruvate, nitrate and thiocyanate. No effect on localization to cell-cell junctions. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26285
Open Targets More...OpenTargetsⁱ	ENSG00000156282
PharmGKBⁱ	PA26564

Polymorphism and mutation databases

BioMutaⁱ	CLDN17
DMDMⁱ	6685309

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144777	1 – 224	Claudin-17Add BLAST		224

Proteomic databases

PaxDbⁱ	P56750
PeptideAtlas More...PeptideAtlasⁱ	P56750
PRIDEⁱ	P56750
ProteomicsDBⁱ	56946

PTM databases

iPTMnetⁱ	P56750
PhosphoSitePlusⁱ	P56750

Expressionⁱ

Tissue specificityⁱ

In the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000156282 Expressed in 33 organ(s), highest expression level in mouth mucosa
CleanExⁱ	HS_CLDN17
Genevisibleⁱ	P56750 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045903

HPAⁱ

HPA045903

Interactionⁱ

Subunit structureⁱ

Interacts with OCLN (PubMed:20375010).1 Publication

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117667, 3 interactors
IntActⁱ	P56750, 1 interactor
STRINGⁱ	9606.ENSP00000286808

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P56750
SMRⁱ	P56750
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the claudin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IJK4 Eukaryota ENOG410YQQY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118928
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG000643
InParanoidⁱ	P56750
KEGG Orthology (KO) More...KOⁱ	K06087
OMAⁱ	ARALMCV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MX2
PhylomeDBⁱ	P56750
TreeFamⁱ	TF331936

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P56750-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAFYPLQIAG LVLGFLGMVG TLATTLLPQW RVSAFVGSNI IVFERLWEGL 
        60         70         80         90        100
WMNCIRQARV RLQCKFYSSL LALPPALETA RALMCVAVAL SLIALLIGIC 
       110        120        130        140        150
GMKQVQCTGS NERAKAYLLG TSGVLFILTG IFVLIPVSWT ANIIIRDFYN 
       160        170        180        190        200
PAIHIGQKRE LGAALFLGWA SAAVLFIGGG LLCGFCCCNR KKQGYRYPVP 
       210        220 
GYRVPHTDKR RNTTMLSKTS TSYV

Length:224

Mass (Da):24,603

Last modified:May 30, 2000 - v1

Checksum:ⁱ1833ED3178B7F63A

GO

Sequence cautionⁱ

The sequence AAQ88461 differs from that shown. Reason: Frameshift at position 31.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_033774	82	A → T. Corresponds to variant dbSNP:rs35531957Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ250712 Genomic DNA Translation: CAB60616.1 AY358094 mRNA Translation: AAQ88461.1 Frameshift. AP001707 Genomic DNA Translation: BAA95566.1 BC101503 mRNA Translation: AAI01504.1 BC101505 mRNA Translation: AAI01506.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13586.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036263.1, NM_012131.2
UniGeneⁱ	Hs.258589

Genome annotation databases

Ensemblⁱ	ENST00000286808; ENSP00000286808; ENSG00000156282
GeneIDⁱ	26285
KEGGⁱ	hsa:26285
UCSC genome browser More...UCSCⁱ	uc011acv.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P56750	Claudin		MACMU		224	UniRef90_P56750
Claudin		MACFA		224
Claudin		MACNE		224
Claudin		SAIBB		224
Claudin		CALJA		224
+29

Protein	Similar proteins		Species	Score	Length	Source
P56750	Claudin-17		PIG		225	UniRef50_P56750
Claudin-17		MOUSE		224
Claudin		PANTR		224
Claudin		CALJA		224
Claudin		CHLSB		224
+111

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ250712 Genomic DNA Translation: CAB60616.1 AY358094 mRNA Translation: AAQ88461.1 Frameshift. AP001707 Genomic DNA Translation: BAA95566.1 BC101503 mRNA Translation: AAI01504.1 BC101505 mRNA Translation: AAI01506.1
CCDSⁱ	CCDS13586.1
RefSeqⁱ	NP_036263.1, NM_012131.2
UniGeneⁱ	Hs.258589

3D structure databases

ProteinModelPortalⁱ	P56750
SMRⁱ	P56750
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117667, 3 interactors
IntActⁱ	P56750, 1 interactor
STRINGⁱ	9606.ENSP00000286808

Protein family/group databases

TCDBⁱ	1.H.1.1.13 the claudin tight junction (claudin1) family

TCDBⁱ

1.H.1.1.13 the claudin tight junction (claudin1) family

PTM databases

iPTMnetⁱ	P56750
PhosphoSitePlusⁱ	P56750

Polymorphism and mutation databases

BioMutaⁱ	CLDN17
DMDMⁱ	6685309

Proteomic databases

PaxDbⁱ	P56750
PeptideAtlasⁱ	P56750
PRIDEⁱ	P56750
ProteomicsDBⁱ	56946

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000286808; ENSP00000286808; ENSG00000156282
GeneIDⁱ	26285
KEGGⁱ	hsa:26285
UCSCⁱ	uc011acv.3 human

Organism-specific databases

CTDⁱ	26285
DisGeNETⁱ	26285
EuPathDBⁱ	HostDB:ENSG00000156282.4
GeneCardsⁱ	CLDN17
HGNCⁱ	HGNC:2038 CLDN17
HPAⁱ	HPA045903
MIMⁱ	617005 gene
neXtProtⁱ	NX_P56750
OpenTargetsⁱ	ENSG00000156282
PharmGKBⁱ	PA26564
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJK4 Eukaryota ENOG410YQQY LUCA
GeneTreeⁱ	ENSGT00760000118928
HOGENOMⁱ	HOG000220937
HOVERGENⁱ	HBG000643
InParanoidⁱ	P56750
KOⁱ	K06087
OMAⁱ	ARALMCV
OrthoDBⁱ	EOG091G0MX2
PhylomeDBⁱ	P56750
TreeFamⁱ	TF331936

Enzyme and pathway databases

Reactomeⁱ	R-HSA-420029 Tight junction interactions

Reactomeⁱ

R-HSA-420029 Tight junction interactions

Miscellaneous databases

GeneWikiⁱ	CLDN17
GenomeRNAiⁱ	26285
Protein Ontology More...PROⁱ	PR:P56750
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000156282 Expressed in 33 organ(s), highest expression level in mouth mucosa
CleanExⁱ	HS_CLDN17
Genevisibleⁱ	P56750 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187 Claudin IPR017974 Claudin_CS IPR004031 PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002 PTHR12002, 1 hit
Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PROSITEⁱ	View protein in PROSITE PS01346 CLAUDIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLD17_HUMAN
Accessionⁱ	P56750Primary (citable) accession number: P56750 Secondary accession number(s): Q3MJB5, Q6UY37
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	May 30, 2000
	Last modified:	November 7, 2018
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - P56750 (CLD17_HUMAN)

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Claudin-17

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ