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Entry version 144 (02 Dec 2020)
Sequence version 1 (30 May 2000)
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Protein

Claudin-17

Gene

CLDN17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P56750

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-420029, Tight junction interactions

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.H.1.1.13, the claudin tight junction (claudin1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Claudin-17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLDN17
ORF Names:UNQ758/PRO1489
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000156282.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2038, CLDN17

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617005, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P56750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7CytoplasmicSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 124CytoplasmicSequence analysisAdd BLAST22
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 164ExtracellularSequence analysisAdd BLAST19
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 224CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi31R → E: Decreased transepithelial resistance and anion selectivity. Higher permeability to chloride, sodium and also to larger anions, including pyruvate, nitrate, and thiocyanate. 1 Publication1
Mutagenesisi44E → A: Decreased transepithelial resistance and anion selectivity. 1 Publication1
Mutagenesisi45R → A: Decreased transepithelial resistance, no effect on anion selectivity. 1 Publication1
Mutagenesisi48E → K or Q: Decreased transepithelial resistance and anion selectivity. Higher permeability to chloride, sodium and also to larger anions, including pyruvate, nitrate, and thiocyanate. 1 Publication1
Mutagenesisi56R → A: No effect on transepithelial resistance, nor on anion selectivity. Elevated permeabilities not only for chloride, but also for sodium and the larger anions, including pyruvate, nitrate and thiocyanate. 1 Publication1
Mutagenesisi56R → T: Decreased anion selectivity. Increased permeabilities not only for chloride, but also for sodium and thiocyanate. No effect on transepithelial resistance. 1 Publication1
Mutagenesisi59R → A: No effect on transepithelial resistance, nor on anion selectivity. Increased permeability for thiocyanate. 1 Publication1
Mutagenesisi61R → A: Decreased anion selectivity. No effect on transepithelial resistance. 1 Publication1
Mutagenesisi65K → A: Reduced channel formation ability. Increased transepithelial resistance. Loss of anion selectivity in favor of cation selectivity. 1 Publication1
Mutagenesisi65K → E: No effect on channel formation ability. Loss of anion selectivity in favor of cation selectivity. No effect on transepithelial resistance. 1 Publication1
Mutagenesisi65K → R: Strongly reduced channel formation ability. Increased transepithelial resistance. Loss of anion selectivity in favor of cation selectivity. 1 Publication1
Mutagenesisi68S → E: Increased transepithelial resistance. Loss of anion selectivity in favor of cation (sodium) selectivity. 1 Publication1
Mutagenesisi149Y → A: Increased transepithelial resistance. No effect on localization to cell-cell junctions. 1 Publication1
Mutagenesisi154H → A: Loss of anion selectivity. Strongly increased permeabilities not only for chloride, but also for sodium and the larger anions, including pyruvate, nitrate and thiocyanate. No effect on localization to cell-cell junctions. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
26285

Open Targets

More...
OpenTargetsi
ENSG00000156282

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26564

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P56750, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLDN17

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6685309

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001447771 – 224Claudin-17Add BLAST224

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P56750

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56750

PeptideAtlas

More...
PeptideAtlasi
P56750

PRoteomics IDEntifications database

More...
PRIDEi
P56750

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56946

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P56750

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P56750

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156282, Expressed in mouth mucosa and 48 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P56750, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000156282, Group enriched (esophagus, salivary gland, tongue, vagina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with OCLN (PubMed:20375010).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117667, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P56750, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000286808

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P56750, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RTNJ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162550

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_076370_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P56750

Identification of Orthologs from Complete Genome Data

More...
OMAi
VCWTANI

Database of Orthologous Groups

More...
OrthoDBi
1314055at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P56750

TreeFam database of animal gene trees

More...
TreeFami
TF331936

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006187, Claudin
IPR017974, Claudin_CS
IPR004031, PMP22/EMP/MP20/Claudin

The PANTHER Classification System

More...
PANTHERi
PTHR12002, PTHR12002, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00822, PMP22_Claudin, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01346, CLAUDIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P56750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFYPLQIAG LVLGFLGMVG TLATTLLPQW RVSAFVGSNI IVFERLWEGL
60 70 80 90 100
WMNCIRQARV RLQCKFYSSL LALPPALETA RALMCVAVAL SLIALLIGIC
110 120 130 140 150
GMKQVQCTGS NERAKAYLLG TSGVLFILTG IFVLIPVSWT ANIIIRDFYN
160 170 180 190 200
PAIHIGQKRE LGAALFLGWA SAAVLFIGGG LLCGFCCCNR KKQGYRYPVP
210 220
GYRVPHTDKR RNTTMLSKTS TSYV
Length:224
Mass (Da):24,603
Last modified:May 30, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1833ED3178B7F63A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ88461 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03377482A → T. Corresponds to variant dbSNP:rs35531957Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ250712 Genomic DNA Translation: CAB60616.1
AY358094 mRNA Translation: AAQ88461.1 Frameshift.
AP001707 Genomic DNA Translation: BAA95566.1
BC101503 mRNA Translation: AAI01504.1
BC101505 mRNA Translation: AAI01506.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13586.1

NCBI Reference Sequences

More...
RefSeqi
NP_036263.1, NM_012131.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000286808; ENSP00000286808; ENSG00000156282

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26285

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26285

UCSC genome browser

More...
UCSCi
uc011acv.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250712 Genomic DNA Translation: CAB60616.1
AY358094 mRNA Translation: AAQ88461.1 Frameshift.
AP001707 Genomic DNA Translation: BAA95566.1
BC101503 mRNA Translation: AAI01504.1
BC101505 mRNA Translation: AAI01506.1
CCDSiCCDS13586.1
RefSeqiNP_036263.1, NM_012131.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117667, 3 interactors
IntActiP56750, 2 interactors
STRINGi9606.ENSP00000286808

Protein family/group databases

TCDBi1.H.1.1.13, the claudin tight junction (claudin1) family

PTM databases

iPTMnetiP56750
PhosphoSitePlusiP56750

Polymorphism and mutation databases

BioMutaiCLDN17
DMDMi6685309

Proteomic databases

MassIVEiP56750
PaxDbiP56750
PeptideAtlasiP56750
PRIDEiP56750
ProteomicsDBi56946

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
6585, 123 antibodies

Genome annotation databases

EnsembliENST00000286808; ENSP00000286808; ENSG00000156282
GeneIDi26285
KEGGihsa:26285
UCSCiuc011acv.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26285
DisGeNETi26285
EuPathDBiHostDB:ENSG00000156282.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CLDN17
HGNCiHGNC:2038, CLDN17
HPAiENSG00000156282, Group enriched (esophagus, salivary gland, tongue, vagina)
MIMi617005, gene
neXtProtiNX_P56750
OpenTargetsiENSG00000156282
PharmGKBiPA26564

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RTNJ, Eukaryota
GeneTreeiENSGT00940000162550
HOGENOMiCLU_076370_1_2_1
InParanoidiP56750
OMAiVCWTANI
OrthoDBi1314055at2759
PhylomeDBiP56750
TreeFamiTF331936

Enzyme and pathway databases

PathwayCommonsiP56750
ReactomeiR-HSA-420029, Tight junction interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
26285, 3 hits in 836 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CLDN17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26285
PharosiP56750, Tdark

Protein Ontology

More...
PROi
PR:P56750
RNActiP56750, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156282, Expressed in mouth mucosa and 48 other tissues
GenevisibleiP56750, HS

Family and domain databases

InterProiView protein in InterPro
IPR006187, Claudin
IPR017974, Claudin_CS
IPR004031, PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002, PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822, PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346, CLAUDIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLD17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56750
Secondary accession number(s): Q3MJB5, Q6UY37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: December 2, 2020
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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