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Protein

Claudin-12

Gene

CLDN12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-12
Gene namesi
Name:CLDN12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000157224.15
HGNCiHGNC:2034 CLDN12
MIMi611232 gene
neXtProtiNX_P56749

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 87ExtracellularSequence analysisAdd BLAST56
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 135CytoplasmicSequence analysisAdd BLAST27
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 174ExtracellularSequence analysisAdd BLAST18
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 244CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi9069
OpenTargetsiENSG00000157224
PharmGKBiPA26560

Polymorphism and mutation databases

BioMutaiCLDN12
DMDMi6685308

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447651 – 244Claudin-12Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei228PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP56749
MaxQBiP56749
PaxDbiP56749
PeptideAtlasiP56749
PRIDEiP56749
ProteomicsDBi56945

PTM databases

iPTMnetiP56749
PhosphoSitePlusiP56749

Expressioni

Gene expression databases

BgeeiENSG00000157224 Expressed in 198 organ(s), highest expression level in secondary oocyte
CleanExiHS_CLDN12
ExpressionAtlasiP56749 baseline and differential
GenevisibleiP56749 HS

Organism-specific databases

HPAiHPA026945

Interactioni

Subunit structurei

Interacts with OCLN (PubMed:20375010).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114527, 7 interactors
IntActiP56749, 4 interactors
STRINGi9606.ENSP00000287916

Structurei

3D structure databases

ProteinModelPortaliP56749
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE44 Eukaryota
ENOG410ZR1K LUCA
GeneTreeiENSGT00400000022250
HOGENOMiHOG000036050
HOVERGENiHBG050986
InParanoidiP56749
OMAiCKTCCCS
OrthoDBiEOG091G0E18
PhylomeDBiP56749
TreeFamiTF331972

Family and domain databases

InterProiView protein in InterPro
IPR013287 Claudin12
IPR017974 Claudin_CS
PANTHERiPTHR16703 PTHR16703, 1 hit
PRINTSiPR01872 CLAUDIN12
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P56749-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCRDVHAAT VLSFLCGIAS VAGLFAGTLL PNWRKLRLIT FNRNEKNLTV
60 70 80 90 100
YTGLWVKCAR YDGSSDCLMY DTTWYSSVDQ LDLRVLQFAL PLSMLIAMGA
110 120 130 140 150
LLLCLIGMCN TAFRSSVPNI KLAKCLVNSA GCHLVAGLLF FLAGTVSLSP
160 170 180 190 200
SIWVIFYNIH LNKKFEPVFS FDYAVYVTIA SAGGLFMTSL ILFIWYCTCK
210 220 230 240
SLPSPFWQPL YSHPPSMHTY SQPYSARSRL SAIEIDIPVV SHTT
Length:244
Mass (Da):27,110
Last modified:May 30, 2000 - v1
Checksum:i0547A9D76392CB5F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MX62A8MX62_HUMAN
Claudin-12
CLDN12
187Annotation score:
C9J4P0C9J4P0_HUMAN
Claudin-12
CLDN12
126Annotation score:
C9J841C9J841_HUMAN
Claudin-12
CLDN12
175Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250713 Genomic DNA Translation: CAB60617.1
AL136770 mRNA Translation: CAB66704.1
AC006153 Genomic DNA Translation: AAP22363.1
CH236949 Genomic DNA Translation: EAL24163.1
CH471091 Genomic DNA Translation: EAW76876.1
CH471091 Genomic DNA Translation: EAW76877.1
BC036754 mRNA Translation: AAH36754.1
BC068532 mRNA Translation: AAH68532.1
CCDSiCCDS5618.1
RefSeqiNP_001172001.1, NM_001185072.2
NP_001172002.1, NM_001185073.2
NP_036261.1, NM_012129.4
UniGeneiHs.731917

Genome annotation databases

EnsembliENST00000287916; ENSP00000287916; ENSG00000157224
ENST00000394605; ENSP00000378103; ENSG00000157224
ENST00000496677; ENSP00000419053; ENSG00000157224
GeneIDi9069
KEGGihsa:9069
UCSCiuc003ukr.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250713 Genomic DNA Translation: CAB60617.1
AL136770 mRNA Translation: CAB66704.1
AC006153 Genomic DNA Translation: AAP22363.1
CH236949 Genomic DNA Translation: EAL24163.1
CH471091 Genomic DNA Translation: EAW76876.1
CH471091 Genomic DNA Translation: EAW76877.1
BC036754 mRNA Translation: AAH36754.1
BC068532 mRNA Translation: AAH68532.1
CCDSiCCDS5618.1
RefSeqiNP_001172001.1, NM_001185072.2
NP_001172002.1, NM_001185073.2
NP_036261.1, NM_012129.4
UniGeneiHs.731917

3D structure databases

ProteinModelPortaliP56749
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114527, 7 interactors
IntActiP56749, 4 interactors
STRINGi9606.ENSP00000287916

PTM databases

iPTMnetiP56749
PhosphoSitePlusiP56749

Polymorphism and mutation databases

BioMutaiCLDN12
DMDMi6685308

Proteomic databases

EPDiP56749
MaxQBiP56749
PaxDbiP56749
PeptideAtlasiP56749
PRIDEiP56749
ProteomicsDBi56945

Protocols and materials databases

DNASUi9069
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287916; ENSP00000287916; ENSG00000157224
ENST00000394605; ENSP00000378103; ENSG00000157224
ENST00000496677; ENSP00000419053; ENSG00000157224
GeneIDi9069
KEGGihsa:9069
UCSCiuc003ukr.4 human

Organism-specific databases

CTDi9069
DisGeNETi9069
EuPathDBiHostDB:ENSG00000157224.15
GeneCardsiCLDN12
HGNCiHGNC:2034 CLDN12
HPAiHPA026945
MIMi611232 gene
neXtProtiNX_P56749
OpenTargetsiENSG00000157224
PharmGKBiPA26560
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE44 Eukaryota
ENOG410ZR1K LUCA
GeneTreeiENSGT00400000022250
HOGENOMiHOG000036050
HOVERGENiHBG050986
InParanoidiP56749
OMAiCKTCCCS
OrthoDBiEOG091G0E18
PhylomeDBiP56749
TreeFamiTF331972

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Miscellaneous databases

GeneWikiiCLDN12
GenomeRNAii9069
PROiPR:P56749
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157224 Expressed in 198 organ(s), highest expression level in secondary oocyte
CleanExiHS_CLDN12
ExpressionAtlasiP56749 baseline and differential
GenevisibleiP56749 HS

Family and domain databases

InterProiView protein in InterPro
IPR013287 Claudin12
IPR017974 Claudin_CS
PANTHERiPTHR16703 PTHR16703, 1 hit
PRINTSiPR01872 CLAUDIN12
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD12_HUMAN
AccessioniPrimary (citable) accession number: P56749
Secondary accession number(s): D6W5Q4, Q7LDZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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