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Protein

Claudin-8

Gene

CLDN8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

Miscellaneous

A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Protein family/group databases

TCDBi1.H.1.1.7 the claudin tight junction (claudin1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-8
Gene namesi
Name:CLDN8Imported
ORF Names:UNQ779/PRO15731 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000156284.5
HGNCiHGNC:2050 CLDN8
MIMi611231 gene
neXtProtiNX_P56748

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 117CytoplasmicSequence analysisAdd BLAST15
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 166ExtracellularSequence analysisAdd BLAST28
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 225CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi9073
OpenTargetsiENSG00000156284
PharmGKBiPA26576

Polymorphism and mutation databases

BioMutaiCLDN8
DMDMi6685307

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447531 – 225Claudin-8Add BLAST225

Post-translational modificationi

Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP56748
PeptideAtlasiP56748
PRIDEiP56748
ProteomicsDBi56944

PTM databases

iPTMnetiP56748
PhosphoSitePlusiP56748

Expressioni

Tissue specificityi

Expressed in the epididymis, mainly in the caput segment.1 Publication

Gene expression databases

BgeeiENSG00000156284 Expressed in 91 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_CLDN8
ExpressionAtlasiP56748 baseline and differential
GenevisibleiP56748 HS

Organism-specific databases

HPAiHPA060605

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with CLDN4. Interacts with KLHL3.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114530, 4 interactors
IntActiP56748, 12 interactors
STRINGi9606.ENSP00000286809

Structurei

3D structure databases

ProteinModelPortaliP56748
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni224 – 225Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJK4 Eukaryota
ENOG410YQQY LUCA
GeneTreeiENSGT00760000118928
HOVERGENiHBG000643
InParanoidiP56748
KOiK06087
OMAiVTIMPQW
OrthoDBiEOG091G0MX2
PhylomeDBiP56748
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003926 Claudin8
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF24 PTHR12002:SF24, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

P56748-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATHALEIAG LFLGGVGMVG TVAVTVMPQW RVSAFIENNI VVFENFWEGL
60 70 80 90 100
WMNCVRQANI RMQCKIYDSL LALSPDLQAA RGLMCAASVM SFLAFMMAIL
110 120 130 140 150
GMKCTRCTGD NEKVKAHILL TAGIIFIITG MVVLIPVSWV ANAIIRDFYN
160 170 180 190 200
SIVNVAQKRE LGEALYLGWT TALVLIVGGA LFCCVFCCNE KSSSYRYSIP
210 220
SHRTTQKSYH TGKKSPSVYS RSQYV
Length:225
Mass (Da):24,845
Last modified:May 30, 2000 - v1
Checksum:iF7920E8E71682473
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170T → A in BAD97232 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04873925T → A. Corresponds to variant dbSNP:rs1557294Ensembl.1
Natural variantiVAR_024417129T → A. Corresponds to variant dbSNP:rs685967Ensembl.1
Natural variantiVAR_020387151S → P1 PublicationCorresponds to variant dbSNP:rs686364Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250711 Genomic DNA Translation: CAB60615.1
AY358707 mRNA Translation: AAQ89070.1
AK223512 mRNA Translation: BAD97232.1
AP001707 Genomic DNA Translation: BAA95567.1
CH471079 Genomic DNA Translation: EAX09901.1
CH471079 Genomic DNA Translation: EAX09902.1
BC020866 mRNA Translation: AAH20866.1
BC058004 mRNA Translation: AAH58004.1
CCDSiCCDS13587.1
RefSeqiNP_955360.1, NM_199328.2
UniGeneiHs.162209

Genome annotation databases

EnsembliENST00000399899; ENSP00000382783; ENSG00000156284
GeneIDi9073
KEGGihsa:9073
UCSCiuc002ynu.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250711 Genomic DNA Translation: CAB60615.1
AY358707 mRNA Translation: AAQ89070.1
AK223512 mRNA Translation: BAD97232.1
AP001707 Genomic DNA Translation: BAA95567.1
CH471079 Genomic DNA Translation: EAX09901.1
CH471079 Genomic DNA Translation: EAX09902.1
BC020866 mRNA Translation: AAH20866.1
BC058004 mRNA Translation: AAH58004.1
CCDSiCCDS13587.1
RefSeqiNP_955360.1, NM_199328.2
UniGeneiHs.162209

3D structure databases

ProteinModelPortaliP56748
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114530, 4 interactors
IntActiP56748, 12 interactors
STRINGi9606.ENSP00000286809

Protein family/group databases

TCDBi1.H.1.1.7 the claudin tight junction (claudin1) family

PTM databases

iPTMnetiP56748
PhosphoSitePlusiP56748

Polymorphism and mutation databases

BioMutaiCLDN8
DMDMi6685307

Proteomic databases

PaxDbiP56748
PeptideAtlasiP56748
PRIDEiP56748
ProteomicsDBi56944

Protocols and materials databases

DNASUi9073
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399899; ENSP00000382783; ENSG00000156284
GeneIDi9073
KEGGihsa:9073
UCSCiuc002ynu.3 human

Organism-specific databases

CTDi9073
DisGeNETi9073
EuPathDBiHostDB:ENSG00000156284.5
GeneCardsiCLDN8
HGNCiHGNC:2050 CLDN8
HPAiHPA060605
MIMi611231 gene
neXtProtiNX_P56748
OpenTargetsiENSG00000156284
PharmGKBiPA26576
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJK4 Eukaryota
ENOG410YQQY LUCA
GeneTreeiENSGT00760000118928
HOVERGENiHBG000643
InParanoidiP56748
KOiK06087
OMAiVTIMPQW
OrthoDBiEOG091G0MX2
PhylomeDBiP56748
TreeFamiTF331936

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Miscellaneous databases

GeneWikiiCLDN8
GenomeRNAii9073
PROiPR:P56748
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156284 Expressed in 91 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_CLDN8
ExpressionAtlasiP56748 baseline and differential
GenevisibleiP56748 HS

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003926 Claudin8
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF24 PTHR12002:SF24, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD8_HUMAN
AccessioniPrimary (citable) accession number: P56748
Secondary accession number(s): D3DSE3, Q53EX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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