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Protein

Claudin-6

Gene

CLDN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space.By similarity
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.2 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • structural molecule activity Source: InterPro
  • virus receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-6
Alternative name(s):
Skullin
Gene namesi
Name:CLDN6
ORF Names:UNQ757/PRO1488
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000184697.6
HGNCiHGNC:2048 CLDN6
MIMi615798 gene
neXtProtiNX_P56747

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 116CytoplasmicSequence analysisAdd BLAST14
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 160ExtracellularSequence analysisAdd BLAST23
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 220CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi9074
OpenTargetsiENSG00000184697
PharmGKBiPA26574

Polymorphism and mutation databases

BioMutaiCLDN6
DMDMi90183180

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447481 – 220Claudin-6Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei201PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP56747
MaxQBiP56747
PaxDbiP56747
PeptideAtlasiP56747
PRIDEiP56747
ProteomicsDBi56943

PTM databases

iPTMnetiP56747
PhosphoSitePlusiP56747
SwissPalmiP56747

Expressioni

Tissue specificityi

Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.1 Publication

Gene expression databases

BgeeiENSG00000184697 Expressed in 60 organ(s), highest expression level in female gonad
CleanExiHS_CLDN6
ExpressionAtlasiP56747 baseline and differential
GenevisibleiP56747 HS

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with CLDN1, CD81 and OCLN (PubMed:20375010).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TMEM179BQ7Z7N94EBI-12955011,EBI-11724423

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114531, 1 interactor
IntActiP56747, 6 interactors
STRINGi9606.ENSP00000328674

Structurei

3D structure databases

ProteinModelPortaliP56747
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 220Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR Eukaryota
ENOG410YA61 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiP56747
KOiK06087
OMAiFGWVNAL
OrthoDBiEOG091G0MMR
PhylomeDBiP56747
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003925 Claudin6
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF41 PTHR12002:SF41, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01445 CLAUDIN6
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P56747-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAGMQILG VVLTLLGWVN GLVSCALPMW KVTAFIGNSI VVAQVVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVIALLV ALFGLLVYLA
110 120 130 140 150
GAKCTTCVEE KDSKARLVLT SGIVFVISGV LTLIPVCWTA HAIIRDFYNP
160 170 180 190 200
LVAEAQKREL GASLYLGWAA SGLLLLGGGL LCCTCPSGGS QGPSHYMARY
210 220
STSAPAISRG PSEYPTKNYV
Length:220
Mass (Da):23,292
Last modified:March 7, 2006 - v2
Checksum:iD80AECB5681502AA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1E7I3L1E7_HUMAN
Claudin-6
CLDN6
39Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017151143I → V4 PublicationsCorresponds to variant dbSNP:rs2257295Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249735 Genomic DNA Translation: CAB56533.1
AF125306 mRNA Translation: AAK02013.1
AY358480 mRNA Translation: AAQ88844.1
BT007399 mRNA Translation: AAP36063.1
AK075329 mRNA Translation: BAG52111.1
CH471112 Genomic DNA Translation: EAW85431.1
CH471112 Genomic DNA Translation: EAW85432.1
BC008934 mRNA Translation: AAH08934.1
CCDSiCCDS10488.1
RefSeqiNP_067018.2, NM_021195.4
UniGeneiHs.533779

Genome annotation databases

EnsembliENST00000328796; ENSP00000328674; ENSG00000184697
ENST00000396925; ENSP00000380131; ENSG00000184697
GeneIDi9074
KEGGihsa:9074
UCSCiuc002csu.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249735 Genomic DNA Translation: CAB56533.1
AF125306 mRNA Translation: AAK02013.1
AY358480 mRNA Translation: AAQ88844.1
BT007399 mRNA Translation: AAP36063.1
AK075329 mRNA Translation: BAG52111.1
CH471112 Genomic DNA Translation: EAW85431.1
CH471112 Genomic DNA Translation: EAW85432.1
BC008934 mRNA Translation: AAH08934.1
CCDSiCCDS10488.1
RefSeqiNP_067018.2, NM_021195.4
UniGeneiHs.533779

3D structure databases

ProteinModelPortaliP56747
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114531, 1 interactor
IntActiP56747, 6 interactors
STRINGi9606.ENSP00000328674

PTM databases

iPTMnetiP56747
PhosphoSitePlusiP56747
SwissPalmiP56747

Polymorphism and mutation databases

BioMutaiCLDN6
DMDMi90183180

Proteomic databases

EPDiP56747
MaxQBiP56747
PaxDbiP56747
PeptideAtlasiP56747
PRIDEiP56747
ProteomicsDBi56943

Protocols and materials databases

DNASUi9074
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328796; ENSP00000328674; ENSG00000184697
ENST00000396925; ENSP00000380131; ENSG00000184697
GeneIDi9074
KEGGihsa:9074
UCSCiuc002csu.5 human

Organism-specific databases

CTDi9074
DisGeNETi9074
EuPathDBiHostDB:ENSG00000184697.6
GeneCardsiCLDN6
HGNCiHGNC:2048 CLDN6
MIMi615798 gene
neXtProtiNX_P56747
OpenTargetsiENSG00000184697
PharmGKBiPA26574
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIJR Eukaryota
ENOG410YA61 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiP56747
KOiK06087
OMAiFGWVNAL
OrthoDBiEOG091G0MMR
PhylomeDBiP56747
TreeFamiTF331936

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Miscellaneous databases

GeneWikiiCLDN6
GenomeRNAii9074
PROiPR:P56747
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184697 Expressed in 60 organ(s), highest expression level in female gonad
CleanExiHS_CLDN6
ExpressionAtlasiP56747 baseline and differential
GenevisibleiP56747 HS

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003925 Claudin6
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF41 PTHR12002:SF41, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01445 CLAUDIN6
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD6_HUMAN
AccessioniPrimary (citable) accession number: P56747
Secondary accession number(s): B3KQP9, D3DUA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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