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UniProtKB - P56737 (TRPD_HELPY)
Protein
Anthranilate phosphoribosyltransferase
Gene
trpD
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
UniRule annotationCatalytic activityi
- diphosphate + N-(5-phospho-β-D-ribosyl)anthranilate = 5-phospho-α-D-ribose 1-diphosphate + anthranilateUniRule annotationEC:2.4.2.18UniRule annotation
Cofactori
Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation
: L-tryptophan biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 79 | Anthranilate 1; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 79 | Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 87 | PhosphoribosylpyrophosphateUniRule annotation | 1 | |
Metal bindingi | 91 | Magnesium 1UniRule annotation | 1 | |
Binding sitei | 119 | Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 165 | Anthranilate 2UniRule annotation | 1 | |
Metal bindingi | 223 | Magnesium 2UniRule annotation | 1 | |
Metal bindingi | 224 | Magnesium 1UniRule annotation | 1 | |
Metal bindingi | 224 | Magnesium 2UniRule annotation | 1 |
GO - Molecular functioni
- anthranilate phosphoribosyltransferase activity Source: UniProtKB-UniRule
- magnesium ion binding Source: UniProtKB-UniRule
GO - Biological processi
- tryptophan biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00035;UER00041 |
Names & Taxonomyi
Protein namesi | Recommended name: Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation) |
Gene namesi | Name:trpDUniRule annotation Ordered Locus Names:HP_1280 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000154449 | 1 – 335 | Anthranilate phosphoribosyltransferaseAdd BLAST | 335 |
Proteomic databases
PaxDbi | P56737 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 85962.C694_06615 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 82 – 83 | Phosphoribosylpyrophosphate bindingUniRule annotation | 2 | |
Regioni | 89 – 92 | Phosphoribosylpyrophosphate bindingUniRule annotation | 4 | |
Regioni | 107 – 115 | Phosphoribosylpyrophosphate bindingUniRule annotation | 9 |
Sequence similaritiesi
Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0547, Bacteria |
OMAi | GPMTNPA |
PhylomeDBi | P56737 |
Family and domain databases
Gene3Di | 3.40.1030.10, 1 hit |
HAMAPi | MF_00211, TrpD, 1 hit |
InterProi | View protein in InterPro IPR005940, Anthranilate_Pribosyl_Tfrase IPR000312, Glycosyl_Trfase_fam3 IPR017459, Glycosyl_Trfase_fam3_N_dom IPR036320, Glycosyl_Trfase_fam3_N_dom)sf IPR035902, Nuc_phospho_transferase |
PANTHERi | PTHR43285, PTHR43285, 1 hit |
Pfami | View protein in Pfam PF02885, Glycos_trans_3N, 1 hit PF00591, Glycos_transf_3, 1 hit |
SUPFAMi | SSF47648, SSF47648, 1 hit SSF52418, SSF52418, 1 hit |
TIGRFAMsi | TIGR01245, trpD, 1 hit |
i Sequence
Sequence statusi: Complete.
P56737-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKEILNALYH QKDLNDEEVK KLFTLIIHEK VSPVQLGAIL CALKIKGESF
60 70 80 90 100
KEISVAATTL LEHAPKPFNS GLDLIDNCGT GGDGLKTINI STIAALIASS
110 120 130 140 150
MGLSMAKHGS RSVSSHSGSA DLLENLGVNI EMNPTQLENC FKQTHFGFLF
160 170 180 190 200
APLYHQSFKK SAPLRKELFT KTIFNCLGPL INPLRPKIQL LGVYDKSLCK
210 220 230 240 250
TMALALKALG VKRAMVVNGG GTDEIVLHDI THACELKNNG ILEYDLSAKD
260 270 280 290 300
FDLPPYDLKE LQIENAQEST QACLDILENK GKDSHTMVVV ANVASLLYLS
310 320 330
HKAKDLKEGV SMTLEHLKTK APYAHLQKII RLSHA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA No translation available. |
PIRi | H64679 |
RefSeqi | NP_208072.1, NC_000915.1 WP_000658921.1, NC_018939.1 |
Genome annotation databases
PATRICi | fig|85962.47.peg.1373 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA No translation available. |
PIRi | H64679 |
RefSeqi | NP_208072.1, NC_000915.1 WP_000658921.1, NC_018939.1 |
3D structure databases
AlphaFoldDBi | P56737 |
SMRi | P56737 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 85962.C694_06615 |
Proteomic databases
PaxDbi | P56737 |
Genome annotation databases
PATRICi | fig|85962.47.peg.1373 |
Phylogenomic databases
eggNOGi | COG0547, Bacteria |
OMAi | GPMTNPA |
PhylomeDBi | P56737 |
Enzyme and pathway databases
UniPathwayi | UPA00035;UER00041 |
Family and domain databases
Gene3Di | 3.40.1030.10, 1 hit |
HAMAPi | MF_00211, TrpD, 1 hit |
InterProi | View protein in InterPro IPR005940, Anthranilate_Pribosyl_Tfrase IPR000312, Glycosyl_Trfase_fam3 IPR017459, Glycosyl_Trfase_fam3_N_dom IPR036320, Glycosyl_Trfase_fam3_N_dom)sf IPR035902, Nuc_phospho_transferase |
PANTHERi | PTHR43285, PTHR43285, 1 hit |
Pfami | View protein in Pfam PF02885, Glycos_trans_3N, 1 hit PF00591, Glycos_transf_3, 1 hit |
SUPFAMi | SSF47648, SSF47648, 1 hit SSF52418, SSF52418, 1 hit |
TIGRFAMsi | TIGR01245, trpD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRPD_HELPY | |
Accessioni | P56737Primary (citable) accession number: P56737 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 30, 2000 | |
Last modified: | May 25, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families