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Protein

Protein Wnt-7b

Gene

WNT7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. Required for normal fusion of the chorion and the allantois during placenta development.By similarity

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor ligand activity Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-373080 Class B/2 (Secretin family receptors)
SIGNORiP56706

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-7b
Gene namesi
Name:WNT7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000188064.9
HGNCiHGNC:12787 WNT7B
MIMi601967 gene
neXtProtiNX_P56706

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7477
OpenTargetsiENSG00000188064
PharmGKBiPA37388

Polymorphism and mutation databases

BioMutaiWNT7B
DMDMi20532426

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004144425 – 349Protein Wnt-7bAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi73 ↔ 84By similarity
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi123 ↔ 131By similarity
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 152By similarity
Disulfide bondi200 ↔ 214By similarity
Disulfide bondi202 ↔ 209By similarity
Lipidationi206O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi294 ↔ 309By similarity
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi324 ↔ 339By similarity
Disulfide bondi326 ↔ 336By similarity
Disulfide bondi331 ↔ 332By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQBiP56706
PaxDbiP56706
PeptideAtlasiP56706
PRIDEiP56706
ProteomicsDBi56939

PTM databases

iPTMnetiP56706
PhosphoSitePlusiP56706

Expressioni

Tissue specificityi

Moderately expressed in fetal brain, weakly expressed in fetal lung and kidney, and faintly expressed in adult brain, lung and prostate.

Gene expression databases

BgeeiENSG00000188064
CleanExiHS_WNT7B
ExpressionAtlasiP56706 baseline and differential
GenevisibleiP56706 HS

Interactioni

Subunit structurei

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Interacts with FZD1 and FZD10. Interacts with FZD4 (in vitro). Interacts with PORCN (By similarity).By similarity1 Publication

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor ligand activity Source: WormBase

Protein-protein interaction databases

BioGridi113314, 7 interactors
IntActiP56706, 3 interactors
STRINGi9606.ENSP00000341032

Structurei

3D structure databases

ProteinModelPortaliP56706
SMRiP56706
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039528
HOVERGENiHBG001595
InParanoidiP56706
KOiK00572
PhylomeDBiP56706
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR013300 Wnt7
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01891 WNT7PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRNFRKWIF YVFLCFGVLY VKLGALSSVV ALGANIICNK IPGLAPRQRA
60 70 80 90 100
ICQSRPDAII VIGEGAQMGI NECQYQFRFG RWNCSALGEK TVFGQELRVG
110 120 130 140 150
SREAAFTYAI TAAGVAHAVT AACSQGNLSN CGCDREKQGY YNQAEGWKWG
160 170 180 190 200
GCSADVRYGI DFSRRFVDAR EIKKNARRLM NLHNNEAGRK VLEDRMQLEC
210 220 230 240 250
KCHGVSGSCT TKTCWTTLPK FREVGHLLKE KYNAAVQVEV VRASRLRQPT
260 270 280 290 300
FLRIKQLRSY QKPMETDLVY IEKSPNYCEE DAATGSVGTQ GRLCNRTSPG
310 320 330 340
ADGCDTMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK
Length:349
Mass (Da):39,327
Last modified:May 10, 2002 - v2
Checksum:iD114C329118C7CB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293L → I no nucleotide entry (PubMed:8168088).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062766 mRNA Translation: BAB68399.1
AF416743 mRNA Translation: AAN32640.1
BX511035 Genomic DNA No translation available.
CR536603 Genomic DNA No translation available.
BC034923 mRNA Translation: AAH34923.1
CCDSiCCDS33667.1
RefSeqiNP_478679.1, NM_058238.2
UniGeneiHs.512714

Genome annotation databases

EnsembliENST00000339464; ENSP00000341032; ENSG00000188064
GeneIDi7477
KEGGihsa:7477
UCSCiuc003bgo.4 human

Similar proteinsi

Entry informationi

Entry nameiWNT7B_HUMAN
AccessioniPrimary (citable) accession number: P56706
Secondary accession number(s): B8A596, Q96Q12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2002
Last modified: July 18, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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