Protein Wnt-3a

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• co-receptor binding Source: ParkinsonsUK-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.8

    "Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6."
    Bourhis E., Tam C., Franke Y., Bazan J.F., Ernst J., Hwang J., Costa M., Cochran A.G., Hannoush R.N.
    J. Biol. Chem. 285:9172-9179(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH LRP6 IN THE WNT/FZD/LRP6 COMPLEX, FUNCTION.
• cytokine activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• frizzled binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: Ensembl
• receptor ligand activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling."
    von Marschall Z., Fisher L.W.
    Biochem Biophys Res Commun 400:299-304(2010) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • Ref.8

    "Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6."
    Bourhis E., Tam C., Franke Y., Bazan J.F., Ernst J., Hwang J., Costa M., Cochran A.G., Hannoush R.N.
    J. Biol. Chem. 285:9172-9179(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH LRP6 IN THE WNT/FZD/LRP6 COMPLEX, FUNCTION.
• transcription coactivator activity Source: Ensembl

GO - Biological processⁱ

• axis elongation involved in somitogenesis Source: Ensembl
• axon guidance Source: Ensembl
• calcium ion transmembrane transport via low voltage-gated calcium channel Source: Ensembl
• canonical Wnt signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis."
    Yokota T., Oritani K., Garrett K.P., Kouro T., Nishida M., Takahashi I., Ichii M., Satoh Y., Kincade P.W., Kanakura Y.
    J Immunol 181:6061-6072(2008) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source: BHF-UCLInferred from direct assayⁱ
  • "Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells."
    Paige S.L., Osugi T., Afanasiev O.K., Pabon L., Reinecke H., Murry C.E.
    PLoS One 5:e11134-e11134(2010) [PubMed] [Europe PMC] [Abstract]
• cell fate commitment Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell population proliferation Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.15

    "Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin."
    Mihara E., Hirai H., Yamamoto H., Tamura-Kawakami K., Matano M., Kikuchi A., Sato T., Takagi J.
    Elife 5:0-0(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH AFM, FUNCTION, SUBCELLULAR LOCATION.
• cell proliferation in forebrain Source: BHF-UCL
• cell proliferation in midbrain Source: ParkinsonsUK-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease."
    Arenas E.
    J Mol Cell Biol 6:42-53(2014) [PubMed] [Europe PMC] [Abstract]
• cellular protein localization Source: Ensembl
• cellular response to retinoic acid Source: UniProtKB
• COP9 signalosome assembly Source: BHF-UCL
• dorsal/ventral neural tube patterning Source: Ensembl
• extracellular matrix organization Source: Ensembl
• heart looping Source: Ensembl
• hemopoiesis Source: Ensembl
• hippocampus development Source: Ensembl
• inner ear morphogenesis Source: Ensembl
• in utero embryonic development Source: Ensembl
• mammary gland development Source: Ensembl
• modulation of chemical synaptic transmission Source: Ensembl
• negative regulation of axon extension involved in axon guidance Source: Ensembl
• negative regulation of dopaminergic neuron differentiation Source: Ensembl
• negative regulation of fat cell differentiation Source: Ensembl
• negative regulation of heart induction by canonical Wnt signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate."
    Stefanovic S., Abboud N., Desilets S., Nury D., Cowan C., Puceat M.
    J Cell Biol 186:665-673(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neurogenesis Source: BHF-UCL
• negative regulation of neuron death Source: Ensembl
• negative regulation of neuron projection development Source: UniProtKB
• neuron differentiation Source: UniProtKB
• osteoblast differentiation Source: Ensembl
• paraxial mesodermal cell fate commitment Source: Ensembl
• platelet aggregation Source: Ensembl
• positive regulation of B cell proliferation Source: Ensembl
• positive regulation of canonical Wnt signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled."
    Gnad T., Feoktistova M., Leverkus M., Lendeckel U., Naumann M.
    Mol Cancer 9:31-31(2010) [PubMed] [Europe PMC] [Abstract]
  • "Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling."
    von Marschall Z., Fisher L.W.
    Biochem Biophys Res Commun 400:299-304(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation Source: Ensembl
• positive regulation of cardiac muscle cell differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells."
    Paige S.L., Osugi T., Afanasiev O.K., Pabon L., Reinecke H., Murry C.E.
    PLoS One 5:e11134-e11134(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
• positive regulation of cell population proliferation Source: BHF-UCL
• positive regulation of collateral sprouting in absence of injury Source: Ensembl
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
• positive regulation of cytokine production Source: Ensembl
• positive regulation of dermatome development Source: BHF-UCLInferred from direct assayⁱ
  • "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm."
    Lee C.S., Buttitta L.A., May N.R., Kispert A., Fan C.M.
    Development 127:109-118(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA-binding transcription factor activity Source: Ensembl
• positive regulation of gene expression Source: BHF-UCLInferred from direct assayⁱ
  • "The microRNA-29 family in cartilage homeostasis and osteoarthritis."
    Le L.T., Swingler T.E., Crowe N., Vincent T.L., Barter M.J., Donell S.T., Delany A.M., Dalmay T., Young D.A., Clark I.M.
    J Mol Med (Berl) 94:583-596(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of hepatocyte proliferation Source: Ensembl
• positive regulation of mesodermal cell fate specification Source: BHF-UCLInferred from direct assayⁱ
  • "Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells."
    Paige S.L., Osugi T., Afanasiev O.K., Pabon L., Reinecke H., Murry C.E.
    PLoS One 5:e11134-e11134(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neural precursor cell proliferation Source: Ensembl
• positive regulation of peptidyl-serine phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • "Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling."
    von Marschall Z., Fisher L.W.
    Biochem Biophys Res Commun 400:299-304(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein binding Source: BHF-UCLInferred from direct assayⁱ
  • "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin."
    Yamamoto H., Komekado H., Kikuchi A.
    Dev Cell 11:213-223(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein localization to plasma membrane Source: Ensembl
• positive regulation of protein phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • "Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled."
    Gnad T., Feoktistova M., Leverkus M., Lendeckel U., Naumann M.
    Mol Cancer 9:31-31(2010) [PubMed] [Europe PMC] [Abstract]
  • "The Hippo pathway regulates Wnt/beta-catenin signaling."
    Varelas X., Miller B.W., Sopko R., Song S., Gregorieff A., Fellouse F.A., Sakuma R., Pawson T., Hunziker W., McNeill H., Wrana J.L., Attisano L.
    Dev Cell 18:579-591(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein tyrosine kinase activity Source: Ensembl
• positive regulation of receptor internalization Source: BHF-UCLInferred from direct assayⁱ
  • "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin."
    Yamamoto H., Komekado H., Kikuchi A.
    Dev Cell 11:213-223(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of skeletal muscle tissue development Source: Ensembl
• positive regulation of transcription, DNA-templated Source: BHF-UCL
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling."
    von Marschall Z., Fisher L.W.
    Biochem Biophys Res Commun 400:299-304(2010) [PubMed] [Europe PMC] [Abstract]
• post-anal tail morphogenesis Source: Ensembl
• postsynapse to nucleus signaling pathway Source: Ensembl
• presynapse assembly Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases."
    Purro S.A., Galli S., Salinas P.C.
    J Mol Cell Biol 6:75-80(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of microtubule cytoskeleton organization Source: Ensembl
• regulation of presynapse assembly Source: SynGOInferred from direct assayⁱ
  • "Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function."
    Varela-Nallar L., Grabowski C.P., Alfaro I.E., Alvarez A.R., Inestrosa N.C.
    Neural Dev 4:41-41(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of synapse organization Source: SynGOInferred from direct assayⁱ
  • "Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation."
    Davis E.K., Zou Y., Ghosh A.
    Neural Dev 3:32-32(2008) [PubMed] [Europe PMC] [Abstract]
• secondary palate development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate."
    Chiquet B.T., Blanton S.H., Burt A., Ma D., Stal S., Mulliken J.B., Hecht J.T.
    Hum Mol Genet 17:2212-2218(2008) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle cell differentiation Source: Ensembl
• somatic stem cell division Source: Ensembl
• spinal cord association neuron differentiation Source: Ensembl
• synaptic vesicle recycling Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The importance of Wnt signalling for neurodegeneration in Parkinson's disease."
    Berwick D.C., Harvey K.
    Biochem Soc Trans 40:1123-1128(2012) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway involved in forebrain neuroblast division Source: Ensembl
• Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The importance of Wnt signalling for neurodegeneration in Parkinson's disease."
    Berwick D.C., Harvey K.
    Biochem Soc Trans 40:1123-1128(2012) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• co-receptor binding Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • Ref.8

    "Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6."
    Bourhis E., Tam C., Franke Y., Bazan J.F., Ernst J., Hwang J., Costa M., Cochran A.G., Hannoush R.N.
    J. Biol. Chem. 285:9172-9179(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH LRP6 IN THE WNT/FZD/LRP6 COMPLEX, FUNCTION.
• cytokine activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• frizzled binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: Ensembl
• receptor ligand activity Source: BHF-UCLInferred from direct assayⁱ
  • "Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling."
    von Marschall Z., Fisher L.W.
    Biochem Biophys Res Commun 400:299-304(2010) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • Ref.8

    "Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6."
    Bourhis E., Tam C., Franke Y., Bazan J.F., Ernst J., Hwang J., Costa M., Cochran A.G., Hannoush R.N.
    J. Biol. Chem. 285:9172-9179(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH LRP6 IN THE WNT/FZD/LRP6 COMPLEX, FUNCTION.

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MAPLGYFLLL CSLKQALGSY PIWWSLAVGP QYSSLGSQPI LCASIPGLVP 
        60         70         80         90        100
KQLRFCRNYV EIMPSVAEGI KIGIQECQHQ FRGRRWNCTT VHDSLAIFGP 
       110        120        130        140        150
VLDKATRESA FVHAIASAGV AFAVTRSCAE GTAAICGCSS RHQGSPGKGW 
       160        170        180        190        200
KWGGCSEDIE FGGMVSREFA DARENRPDAR SAMNRHNNEA GRQAIASHMH 
       210        220        230        240        250
LKCKCHGLSG SCEVKTCWWS QPDFRAIGDF LKDKYDSASE MVVEKHRESR 
       260        270        280        290        300
GWVETLRPRY TYFKVPTERD LVYYEASPNF CEPNPETGSF GTRDRTCNVS 
       310        320        330        340        350
SHGIDGCDLL CCGRGHNARA ERRREKCRCV FHWCCYVSCQ ECTRVYDVHT 

CK                                                     

        10         20         30         40         50
MAPLGYFLLL CSLKQALGSY PIWWSLAVGP QYSSLGSQPI LCASIPGLVP 
        60         70         80         90        100
KQLRFCRNYV EIMPSVAEGI KIGIQECQHQ FRGRRWNCTT VHDSLAIFGP 
       110        120        130        140        150
VLDKATRESA FVHAIASAGV AFAVTRSCAE GTAAICGCSS RHQGSPGKGW 
       160        170        180        190        200
KWGGCSEDIE FGGMVSREFA DARENRPDAR SAMNRHNNEA GRQAIASHMH 
       210        220        230        240        250
LKCKCHGLSG SCEVKTCWWS QPDFRAIGDF LKDKYDSASE MVVEKHRESR 
       260        270        280        290        300
GWVETLRPRY TYFKVPTERD LVYYEASPNF CEPNPETGSF GTRDRTCNVS 
       310        320        330        340        350
SHGIDGCDLL CCGRGHNARA ERRREKCRCV FHWCCYVSCQ ECTRVYDVHT 
       360        370        380 
CKNPGSRAGN SAHQPPHPQP PVRFHPPLRR AGKVP                 

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families