UniProtKB - P56703 (WNT3_HUMAN)
Proto-oncogene Wnt-3
WNT3
Functioni
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720).
Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity).
Required for normal embryonic development, and especially for limb development (PubMed:14872406).
By similarityCurated2 PublicationsGO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: UniProtKB
- protein domain specific binding Source: Ensembl
- receptor ligand activity Source: ParkinsonsUK-UCL
GO - Biological processi
- anterior/posterior axis specification Source: Ensembl
- axon guidance Source: Ensembl
- canonical Wnt signaling pathway Source: UniProtKB
- canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: BHF-UCL
- canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
- canonical Wnt signaling pathway involved in osteoblast differentiation Source: BHF-UCL
- canonical Wnt signaling pathway involved in stem cell proliferation Source: ParkinsonsUK-UCL
- cell fate commitment Source: GO_Central
- cell morphogenesis Source: BHF-UCL
- cellular response to retinoic acid Source: UniProtKB
- dorsal/ventral axis specification Source: Ensembl
- embryonic forelimb morphogenesis Source: Ensembl
- embryonic hindlimb morphogenesis Source: Ensembl
- gamete generation Source: Ensembl
- head morphogenesis Source: Ensembl
- limb bud formation Source: BHF-UCL
- mammary gland epithelium development Source: UniProtKB
- mesoderm formation Source: Ensembl
- negative regulation of axon extension involved in axon guidance Source: Ensembl
- neuron differentiation Source: UniProtKB
- positive regulation of collateral sprouting in absence of injury Source: Ensembl
- positive regulation of gene expression Source: ParkinsonsUK-UCL
- positive regulation of Wnt signaling pathway Source: Ensembl
- regulation of neurogenesis Source: ParkinsonsUK-UCL
- Spemann organizer formation at the anterior end of the primitive streak Source: Ensembl
- stem cell proliferation Source: ParkinsonsUK-UCL
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | P56703 |
Reactomei | R-HSA-201681, TCF dependent signaling in response to WNT R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) |
SignaLinki | P56703 |
SIGNORi | P56703 |
Names & Taxonomyi
Protein namesi | Recommended name: Proto-oncogene Wnt-3Alternative name(s): Proto-oncogene Int-4 homolog |
Gene namesi | Name:WNT3 Synonyms:INT4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12782, WNT3 |
MIMi | 165330, gene |
neXtProti | NX_P56703 |
VEuPathDBi | HostDB:ENSG00000108379 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix Curated
- Secreted 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: Reactome
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Golgi apparatus
- Golgi lumen Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- endocytic vesicle membrane Source: Reactome
- extracellular matrix Source: Ensembl
- Wnt signalosome Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Tetraamelia syndrome 1 (TETAMS1)1 Publication
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 7473 |
MalaCardsi | WNT3 |
MIMi | 273395, phenotype |
OpenTargetsi | ENSG00000108379 |
Orphaneti | 3301, Tetraamelia-multiple malformations syndrome |
PharmGKBi | PA37383 |
Miscellaneous databases
Pharosi | P56703, Tchem |
Chemistry databases
ChEMBLi | CHEMBL6079 |
Genetic variation databases
BioMutai | WNT3 |
DMDMi | 14424477 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000041416 | 22 – 355 | Proto-oncogene Wnt-3Add BLAST | 334 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 80 ↔ 91 | By similarity | ||
Glycosylationi | 90 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 131 ↔ 139 | By similarity | ||
Disulfide bondi | 141 ↔ 158 | By similarity | ||
Disulfide bondi | 206 ↔ 220 | By similarity | ||
Disulfide bondi | 208 ↔ 215 | By similarity | ||
Lipidationi | 212 | O-palmitoleoyl serine; by PORCNBy similarity | 1 | |
Disulfide bondi | 284 ↔ 315 | By similarity | ||
Disulfide bondi | 300 ↔ 310 | By similarity | ||
Glycosylationi | 301 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 314 ↔ 354 | By similarity | ||
Disulfide bondi | 330 ↔ 345 | By similarity | ||
Disulfide bondi | 332 ↔ 342 | By similarity | ||
Disulfide bondi | 337 ↔ 338 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, LipoproteinProteomic databases
EPDi | P56703 |
MassIVEi | P56703 |
PaxDbi | P56703 |
PeptideAtlasi | P56703 |
PRIDEi | P56703 |
ProteomicsDBi | 56936 |
PTM databases
GlyGeni | P56703, 2 sites |
iPTMneti | P56703 |
PhosphoSitePlusi | P56703 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108379, Expressed in skin of abdomen and 150 other tissues |
Genevisiblei | P56703, HS |
Organism-specific databases
HPAi | ENSG00000108379, Group enriched (liver, skin) |
Interactioni
Subunit structurei
Binary interactionsi
GO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: UniProtKB
- protein domain specific binding Source: Ensembl
- receptor ligand activity Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 113310, 4 interactors |
IntActi | P56703, 3 interactors |
STRINGi | 9606.ENSP00000225512 |
Chemistry databases
BindingDBi | P56703 |
Miscellaneous databases
RNActi | P56703, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P56703 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000157854 |
HOGENOMi | CLU_033039_1_0_1 |
InParanoidi | P56703 |
OMAi | NFCEPNS |
OrthoDBi | 965867at2759 |
PhylomeDBi | P56703 |
TreeFami | TF105310 |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR009141, Wnt3 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01843, WNT3PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MEPHLLGLLL GLLLGGTRVL AGYPIWWSLA LGQQYTSLGS QPLLCGSIPG
60 70 80 90 100
LVPKQLRFCR NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI
110 120 130 140 150
FGPVLDKATR ESAFVHAIAS AGVAFAVTRS CAEGTSTICG CDSHHKGPPG
160 170 180 190 200
EGWKWGGCSE DADFGVLVSR EFADARENRP DARSAMNKHN NEAGRTTILD
210 220 230 240 250
HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS ASEMVVEKHR
260 270 280 290 300
ESRGWVETLR AKYSLFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC
310 320 330 340 350
NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECIRIYD
VHTCK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY009397 mRNA Translation: AAG38657.1 AB067628 mRNA Translation: BAB70502.1 BC112116 mRNA Translation: AAI12117.1 BC112118 mRNA Translation: AAI12119.1 BC114219 mRNA Translation: AAI14220.1 |
CCDSi | CCDS11505.1 |
PIRi | A47536 |
RefSeqi | NP_110380.1, NM_030753.4 |
Genome annotation databases
Ensembli | ENST00000225512; ENSP00000225512; ENSG00000108379 ENST00000611547; ENSP00000478327; ENSG00000277626 ENST00000616347; ENSP00000480990; ENSG00000277641 |
GeneIDi | 7473 |
KEGGi | hsa:7473 |
MANE-Selecti | ENST00000225512.6; ENSP00000225512.5; NM_030753.5; NP_110380.1 |
UCSCi | uc002ikv.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY009397 mRNA Translation: AAG38657.1 AB067628 mRNA Translation: BAB70502.1 BC112116 mRNA Translation: AAI12117.1 BC112118 mRNA Translation: AAI12119.1 BC114219 mRNA Translation: AAI14220.1 |
CCDSi | CCDS11505.1 |
PIRi | A47536 |
RefSeqi | NP_110380.1, NM_030753.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6AHY | X-ray | 2.80 | B/D/F | 42-355 | [»] | |
SMRi | P56703 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113310, 4 interactors |
IntActi | P56703, 3 interactors |
STRINGi | 9606.ENSP00000225512 |
Chemistry databases
BindingDBi | P56703 |
ChEMBLi | CHEMBL6079 |
PTM databases
GlyGeni | P56703, 2 sites |
iPTMneti | P56703 |
PhosphoSitePlusi | P56703 |
Genetic variation databases
BioMutai | WNT3 |
DMDMi | 14424477 |
Proteomic databases
EPDi | P56703 |
MassIVEi | P56703 |
PaxDbi | P56703 |
PeptideAtlasi | P56703 |
PRIDEi | P56703 |
ProteomicsDBi | 56936 |
Protocols and materials databases
Antibodypediai | 30108, 453 antibodies from 31 providers |
DNASUi | 7473 |
Genome annotation databases
Ensembli | ENST00000225512; ENSP00000225512; ENSG00000108379 ENST00000611547; ENSP00000478327; ENSG00000277626 ENST00000616347; ENSP00000480990; ENSG00000277641 |
GeneIDi | 7473 |
KEGGi | hsa:7473 |
MANE-Selecti | ENST00000225512.6; ENSP00000225512.5; NM_030753.5; NP_110380.1 |
UCSCi | uc002ikv.3, human |
Organism-specific databases
CTDi | 7473 |
DisGeNETi | 7473 |
GeneCardsi | WNT3 |
HGNCi | HGNC:12782, WNT3 |
HPAi | ENSG00000108379, Group enriched (liver, skin) |
MalaCardsi | WNT3 |
MIMi | 165330, gene 273395, phenotype |
neXtProti | NX_P56703 |
OpenTargetsi | ENSG00000108379 |
Orphaneti | 3301, Tetraamelia-multiple malformations syndrome |
PharmGKBi | PA37383 |
VEuPathDBi | HostDB:ENSG00000108379 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000157854 |
HOGENOMi | CLU_033039_1_0_1 |
InParanoidi | P56703 |
OMAi | NFCEPNS |
OrthoDBi | 965867at2759 |
PhylomeDBi | P56703 |
TreeFami | TF105310 |
Enzyme and pathway databases
PathwayCommonsi | P56703 |
Reactomei | R-HSA-201681, TCF dependent signaling in response to WNT R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) |
SignaLinki | P56703 |
SIGNORi | P56703 |
Miscellaneous databases
BioGRID-ORCSi | 7473, 9 hits in 1046 CRISPR screens |
ChiTaRSi | WNT3, human |
GeneWikii | WNT3 |
GenomeRNAii | 7473 |
Pharosi | P56703, Tchem |
PROi | PR:P56703 |
RNActi | P56703, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108379, Expressed in skin of abdomen and 150 other tissues |
Genevisiblei | P56703, HS |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR009141, Wnt3 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01843, WNT3PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WNT3_HUMAN | |
Accessioni | P56703Primary (citable) accession number: P56703 Secondary accession number(s): Q2M237, Q9H1J9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | June 20, 2001 | |
Last modified: | February 23, 2022 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families