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UniProtKB - P56703 (WNT3_HUMAN)

Entry version 179 (23 Feb 2022)
Sequence version 2 (20 Jun 2001)
Previous versions | rss
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Protein

Proto-oncogene Wnt-3

Gene

WNT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720).

Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity).

Required for normal embryonic development, and especially for limb development (PubMed:14872406).

By similarityCurated2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P56703

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-201681, TCF dependent signaling in response to WNT
R-HSA-3238698, WNT ligand biogenesis and trafficking
R-HSA-373080, Class B/2 (Secretin family receptors)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P56703

SIGNOR Signaling Network Open Resource

More...SIGNORi		P56703

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proto-oncogene Wnt-3
Alternative name(s):
Proto-oncogene Int-4 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WNT3
Synonyms:INT4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12782, WNT3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		165330, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P56703

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000108379

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Tetraamelia syndrome 1 (TETAMS1)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of tetraamelia, a rare disease characterized by rudimentary appendages or complete absence of all four limbs, and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. TETAMS1 patients manifest complete limb agenesis without defects of scapulae or clavicles. Other features include bilateral cleft lip/palate, diaphragmatic defect with bilobar right lung, renal and adrenal agenesis, pelvic hypoplasia, and urogenital defects. TETAMS1 transmission pattern is consistent with autosomal recessive inheritance.
Related information in OMIM

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		7473

MalaCards human disease database

More...MalaCardsi		WNT3
MIMi273395, phenotype

Open Targets

More...OpenTargetsi		ENSG00000108379

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		3301, Tetraamelia-multiple malformations syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37383

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P56703, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL6079

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		WNT3

Domain mapping of disease mutations (DMDM)

More...DMDMi		14424477

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004141622 – 355Proto-oncogene Wnt-3Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi80 ↔ 91By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 139By similarity
Disulfide bondi141 ↔ 158By similarity
Disulfide bondi206 ↔ 220By similarity
Disulfide bondi208 ↔ 215By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi212O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi284 ↔ 315By similarity
Disulfide bondi300 ↔ 310By similarity
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi314 ↔ 354By similarity
Disulfide bondi330 ↔ 345By similarity
Disulfide bondi332 ↔ 342By similarity
Disulfide bondi337 ↔ 338By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P56703

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P56703

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P56703

PeptideAtlas

More...PeptideAtlasi		P56703

PRoteomics IDEntifications database

More...PRIDEi		P56703

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56936

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P56703, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P56703

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P56703

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108379, Expressed in skin of abdomen and 150 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P56703, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000108379, Group enriched (liver, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).

Interacts with PORCN.

Interacts with WLS (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113310, 4 interactors

Protein interaction database and analysis system

More...IntActi		P56703, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000225512

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P56703

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P56703, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1355
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P56703

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3913, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157854

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033039_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P56703

Identification of Orthologs from Complete Genome Data

More...OMAi		NFCEPNS

Database of Orthologous Groups

More...OrthoDBi		965867at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P56703

TreeFam database of animal gene trees

More...TreeFami		TF105310

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.2460.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005817, Wnt
IPR009141, Wnt3
IPR043158, Wnt_C
IPR018161, Wnt_CS

The PANTHER Classification System

More...PANTHERi		PTHR12027, PTHR12027, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00110, wnt, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01843, WNT3PROTEIN
PR01349, WNTPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00097, WNT1, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00246, WNT1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P56703-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPHLLGLLL GLLLGGTRVL AGYPIWWSLA LGQQYTSLGS QPLLCGSIPG 
        60         70         80         90        100
LVPKQLRFCR NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI 
       110        120        130        140        150
FGPVLDKATR ESAFVHAIAS AGVAFAVTRS CAEGTSTICG CDSHHKGPPG 
       160        170        180        190        200
EGWKWGGCSE DADFGVLVSR EFADARENRP DARSAMNKHN NEAGRTTILD 
       210        220        230        240        250
HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS ASEMVVEKHR 
       260        270        280        290        300
ESRGWVETLR AKYSLFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC 
       310        320        330        340        350
NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECIRIYD 

VHTCK
Length:355
Mass (Da):39,645
Last modified:June 20, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i85D15F2C7884A64F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY009397 mRNA Translation: AAG38657.1
AB067628 mRNA Translation: BAB70502.1
BC112116 mRNA Translation: AAI12117.1
BC112118 mRNA Translation: AAI12119.1
BC114219 mRNA Translation: AAI14220.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11505.1

Protein sequence database of the Protein Information Resource

More...PIRi		A47536

NCBI Reference Sequences

More...RefSeqi		NP_110380.1, NM_030753.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000225512; ENSP00000225512; ENSG00000108379
ENST00000611547; ENSP00000478327; ENSG00000277626
ENST00000616347; ENSP00000480990; ENSG00000277641

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7473

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7473

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000225512.6; ENSP00000225512.5; NM_030753.5; NP_110380.1

UCSC genome browser

More...UCSCi		uc002ikv.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009397 mRNA Translation: AAG38657.1
AB067628 mRNA Translation: BAB70502.1
BC112116 mRNA Translation: AAI12117.1
BC112118 mRNA Translation: AAI12119.1
BC114219 mRNA Translation: AAI14220.1
CCDSiCCDS11505.1
PIRiA47536
RefSeqiNP_110380.1, NM_030753.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6AHYX-ray2.80B/D/F42-355[»]
SMRiP56703
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113310, 4 interactors
IntActiP56703, 3 interactors
STRINGi9606.ENSP00000225512

Chemistry databases

BindingDBiP56703
ChEMBLiCHEMBL6079

PTM databases

GlyGeniP56703, 2 sites
iPTMnetiP56703
PhosphoSitePlusiP56703

Genetic variation databases

BioMutaiWNT3
DMDMi14424477

Proteomic databases

EPDiP56703
MassIVEiP56703
PaxDbiP56703
PeptideAtlasiP56703
PRIDEiP56703
ProteomicsDBi56936

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30108, 453 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		7473

Genome annotation databases

EnsembliENST00000225512; ENSP00000225512; ENSG00000108379
ENST00000611547; ENSP00000478327; ENSG00000277626
ENST00000616347; ENSP00000480990; ENSG00000277641
GeneIDi7473
KEGGihsa:7473
MANE-SelectiENST00000225512.6; ENSP00000225512.5; NM_030753.5; NP_110380.1
UCSCiuc002ikv.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7473
DisGeNETi7473

GeneCards: human genes, protein and diseases

More...GeneCardsi		WNT3
HGNCiHGNC:12782, WNT3
HPAiENSG00000108379, Group enriched (liver, skin)
MalaCardsiWNT3
MIMi165330, gene
273395, phenotype
neXtProtiNX_P56703
OpenTargetsiENSG00000108379
Orphaneti3301, Tetraamelia-multiple malformations syndrome
PharmGKBiPA37383
VEuPathDBiHostDB:ENSG00000108379

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3913, Eukaryota
GeneTreeiENSGT00940000157854
HOGENOMiCLU_033039_1_0_1
InParanoidiP56703
OMAiNFCEPNS
OrthoDBi965867at2759
PhylomeDBiP56703
TreeFamiTF105310

Enzyme and pathway databases

PathwayCommonsiP56703
ReactomeiR-HSA-201681, TCF dependent signaling in response to WNT
R-HSA-3238698, WNT ligand biogenesis and trafficking
R-HSA-373080, Class B/2 (Secretin family receptors)
SignaLinkiP56703
SIGNORiP56703

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7473, 9 hits in 1046 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		WNT3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		WNT3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7473
PharosiP56703, Tchem

Protein Ontology

More...PROi		PR:P56703
RNActiP56703, protein

The Stanford Online Universal Resource for Clones and ESTs

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Gene expression databases

BgeeiENSG00000108379, Expressed in skin of abdomen and 150 other tissues
GenevisibleiP56703, HS

Family and domain databases

Gene3Di3.30.2460.20, 1 hit
InterProiView protein in InterPro
IPR005817, Wnt
IPR009141, Wnt3
IPR043158, Wnt_C
IPR018161, Wnt_CS
PANTHERiPTHR12027, PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110, wnt, 1 hit
PRINTSiPR01843, WNT3PROTEIN
PR01349, WNTPROTEIN
SMARTiView protein in SMART
SM00097, WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246, WNT1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWNT3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56703
Secondary accession number(s): Q2M237, Q9H1J9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 20, 2001
Last modified: February 23, 2022
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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