Proto-oncogene Wnt-3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• frizzled binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response."
    Gazit A., Yaniv A., Bafico A., Pramila T., Igarashi M., Kitajewski J., Aaronson S.A.
    Oncogene 18:5959-5966(1999) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: Ensembl
• receptor ligand activity Source: ParkinsonsUK-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response."
    Gazit A., Yaniv A., Bafico A., Pramila T., Igarashi M., Kitajewski J., Aaronson S.A.
    Oncogene 18:5959-5966(1999) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anterior/posterior axis specification Source: Ensembl
• axon guidance Source: Ensembl
• canonical Wnt signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response."
    Gazit A., Yaniv A., Bafico A., Pramila T., Igarashi M., Kitajewski J., Aaronson S.A.
    Oncogene 18:5959-5966(1999) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling."
    Bhat R.A., Stauffer B., Della Pietra A., Bodine P.V.
    J. Cell. Biochem. 109:876-884(2010) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation."
    Lee C.T., Bendriem R.M., Kindberg A.A., Worden L.T., Williams M.P., Drgon T., Mallon B.S., Harvey B.K., Richie C.T., Hamilton R.S., Chen J., Errico S.L., Tsai S.Y., Uhl G.R., Freed W.J.
    Cell Rep 10:616-632(2015) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway involved in osteoblast differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling."
    Bhat R.A., Stauffer B., Della Pietra A., Bodine P.V.
    J. Cell. Biochem. 109:876-884(2010) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway involved in stem cell proliferation Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation."
    Lee C.T., Bendriem R.M., Kindberg A.A., Worden L.T., Williams M.P., Drgon T., Mallon B.S., Harvey B.K., Richie C.T., Hamilton R.S., Chen J., Errico S.L., Tsai S.Y., Uhl G.R., Freed W.J.
    Cell Rep 10:616-632(2015) [PubMed] [Europe PMC] [Abstract]
• cell fate commitment Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells."
    Chiba H., Kobune M., Kato J., Kawano Y., Ito Y., Nakamura K., Asakura S., Hamada H., Niitsu Y.
    Exp. Hematol. 32:1194-1203(2004) [PubMed] [Europe PMC] [Abstract]
• cellular response to retinoic acid Source: UniProtKB
• dorsal/ventral axis specification Source: Ensembl
• embryonic forelimb morphogenesis Source: Ensembl
• embryonic hindlimb morphogenesis Source: Ensembl
• gamete generation Source: Ensembl
• head morphogenesis Source: Ensembl
• limb bud formation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.5

    "Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family."
    Niemann S., Zhao C., Pascu F., Stahl U., Aulepp U., Niswander L., Weber J.L., Mueller U.
    Am. J. Hum. Genet. 74:558-563(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: INVOLVEMENT IN TETAMS1.
• mammary gland epithelium development Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue."
    Huguet E.L., McMahon J.A., McMahon A.P., Bicknell R., Harris A.L.
    Cancer Res. 54:2615-2621(1994) [PubMed] [Europe PMC] [Abstract]
• mesoderm formation Source: Ensembl
• negative regulation of axon extension involved in axon guidance Source: Ensembl
• neuron differentiation Source: UniProtKB
• positive regulation of collateral sprouting in absence of injury Source: Ensembl
• positive regulation of gene expression Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation."
    Lee C.T., Bendriem R.M., Kindberg A.A., Worden L.T., Williams M.P., Drgon T., Mallon B.S., Harvey B.K., Richie C.T., Hamilton R.S., Chen J., Errico S.L., Tsai S.Y., Uhl G.R., Freed W.J.
    Cell Rep 10:616-632(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of Wnt signaling pathway Source: Ensembl
• regulation of neurogenesis Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation."
    Lee C.T., Bendriem R.M., Kindberg A.A., Worden L.T., Williams M.P., Drgon T., Mallon B.S., Harvey B.K., Richie C.T., Hamilton R.S., Chen J., Errico S.L., Tsai S.Y., Uhl G.R., Freed W.J.
    Cell Rep 10:616-632(2015) [PubMed] [Europe PMC] [Abstract]
• Spemann organizer formation at the anterior end of the primitive streak Source: Ensembl
• stem cell proliferation Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation."
    Lee C.T., Bendriem R.M., Kindberg A.A., Worden L.T., Williams M.P., Drgon T., Mallon B.S., Harvey B.K., Richie C.T., Hamilton R.S., Chen J., Errico S.L., Tsai S.Y., Uhl G.R., Freed W.J.
    Cell Rep 10:616-632(2015) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• frizzled binding Source: UniProtKBInferred from physical interactionⁱ
  • "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response."
    Gazit A., Yaniv A., Bafico A., Pramila T., Igarashi M., Kitajewski J., Aaronson S.A.
    Oncogene 18:5959-5966(1999) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: Ensembl
• receptor ligand activity Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response."
    Gazit A., Yaniv A., Bafico A., Pramila T., Igarashi M., Kitajewski J., Aaronson S.A.
    Oncogene 18:5959-5966(1999) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MEPHLLGLLL GLLLGGTRVL AGYPIWWSLA LGQQYTSLGS QPLLCGSIPG 
        60         70         80         90        100
LVPKQLRFCR NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI 
       110        120        130        140        150
FGPVLDKATR ESAFVHAIAS AGVAFAVTRS CAEGTSTICG CDSHHKGPPG 
       160        170        180        190        200
EGWKWGGCSE DADFGVLVSR EFADARENRP DARSAMNKHN NEAGRTTILD 
       210        220        230        240        250
HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS ASEMVVEKHR 
       260        270        280        290        300
ESRGWVETLR AKYSLFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC 
       310        320        330        340        350
NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECIRIYD 

VHTCK                                                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
4. Human chromosome 17
   Human chromosome 17: entries, gene names and cross-references to MIM