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UniProtKB - P56673 (PITX1_CHICK)
Protein
Pituitary homeobox 1
Gene
PITX1
Organism
Gallus gallus (Chicken)
Status
Functioni
Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Acts as a transcriptional activator by binding to promoter sequences with a TAAT/GCC core motif.
3 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 88 – 147 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Pituitary homeobox 1Alternative name(s): Homeobox protein PITX1 Paired-like homeodomain transcription factor 1 cPTX1 |
Gene namesi | Name:PITX1 Synonyms:PTX1 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049221 | 1 – 311 | Pituitary homeobox 1Add BLAST | 311 |
Expressioni
Tissue specificityi
Expressed in primordial Rathke pouch, oral epithelium, first branchial arch, duodenum, and hindlimb.
Developmental stagei
In the head region, first detected in 10-somite embryos in the stomodeum and rostral foregut. At day 3, expressed in Rathke pouch, in the mandibular and oral epithelia, in the foregut endoderm and in the posterior lateral plate mesoderm. Expression is maintained in these structures in later stages and at day 5, can be seen in the distal portion of the hindlimb.1 Publication
Gene expression databases
Bgeei | ENSGALG00000006365, Expressed in skeletal muscle tissue and 3 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 102 | DisorderedSequence analysisAdd BLAST | 102 | |
Regioni | 148 – 277 | Interaction with PIT-1By similarityAdd BLAST | 130 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 278 – 291 | OARPROSITE-ProRule annotationAdd BLAST | 14 | |
Motifi | 284 – 288 | Nuclear localization signalSequence analysis | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 42 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 43 – 67 | Basic and acidic residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0486, Eukaryota |
HOGENOMi | CLU_030301_0_0_1 |
InParanoidi | P56673 |
OrthoDBi | 1432356at2759 |
PhylomeDBi | P56673 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR016233, Homeobox_Pitx/unc30 IPR003654, OAR_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PIRSFi | PIRSF000563, Homeobox_protein_Pitx/Unc30, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
i Sequence
Sequence statusi: Complete.
P56673-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSFKGGMNL ERLPESLRPQ PSHDMASSFH LQRSSEPRDP IENSASESSD
60 70 80 90 100
TDVPEKERSE SRKTREDGGA GSAGCTGAAD DPAKKKKQRR QRTHFTSQQL
110 120 130 140 150
QELEATFQRN RYPDMSMREE IAVWTNLTEP RVRVWFKNRR AKWRKRERNQ
160 170 180 190 200
QMDLCKNGYV PQFSGLMQPY DDMYAGYPYN NWATKSLTPA PLSTKSFTFF
210 220 230 240 250
NSMSPLSSQS MFSAPSSISS MNMPSGMGHS AVPGMANSGL NNINNISGSS
260 270 280 290 300
LNSAMSSPAC PYGPPGSPYS VYRDTCNSSL ASLALKSKQH SSFGYSSLQS
310
PGSSLNACQY N
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 52 | D → E in AAC23684 (PubMed:9655805).Curated | 1 | |
Sequence conflicti | 60 – 65 | ESRKTR → GEQKN (PubMed:9655805).Curated | 6 | |
Sequence conflicti | 69 – 77 | Missing (PubMed:9655805).Curated | 9 | |
Sequence conflicti | 284 | A → R in AAC23684 (PubMed:9655805).Curated | 1 | |
Sequence conflicti | 311 | N → NS in AAC23684 (PubMed:9655805).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF069397 mRNA Translation: AAC23684.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF069397 mRNA Translation: AAC23684.1 |
3D structure databases
SMRi | P56673 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000009413 |
Phylogenomic databases
eggNOGi | KOG0486, Eukaryota |
HOGENOMi | CLU_030301_0_0_1 |
InParanoidi | P56673 |
OrthoDBi | 1432356at2759 |
PhylomeDBi | P56673 |
Gene expression databases
Bgeei | ENSGALG00000006365, Expressed in skeletal muscle tissue and 3 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR016233, Homeobox_Pitx/unc30 IPR003654, OAR_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PIRSFi | PIRSF000563, Homeobox_protein_Pitx/Unc30, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PITX1_CHICK | |
Accessioni | P56673Primary (citable) accession number: P56673 Secondary accession number(s): O93358 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 15, 1999 | |
Last modified: | September 29, 2021 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families