UniProtKB - P56672 (OTP_DROME)
Protein
Homeobox protein orthopedia
Gene
otp
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May be involved in the development of the central nervous system.1 Publication
Caution
It is uncertain whether Met-1 is the initiator or if the sequence starts further upstream.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 109 – 168 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: FlyBase
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein orthopedia |
Gene namesi | Name:otp ORF Names:CG10036 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0015524, otp |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049206 | 1 – 409 | Homeobox protein orthopediaAdd BLAST | 409 |
Proteomic databases
PaxDbi | P56672 |
Expressioni
Tissue specificityi
First appears at gastrulation in the ectodermal proctodeum and later in the hindgut, anal plate, and along the CNS.1 Publication
Gene expression databases
Bgeei | FBgn0015524, Expressed in digestive system element and 31 other tissues |
ExpressionAtlasi | P56672, baseline and differential |
Genevisiblei | P56672, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 63008, 18 interactors |
DIPi | DIP-17198N |
IntActi | P56672, 19 interactors |
STRINGi | 7227.FBpp0288728 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 372 – 385 | OARPROSITE-ProRule annotationAdd BLAST | 14 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 28 – 98 | Gly-richAdd BLAST | 71 | |
Compositional biasi | 75 – 102 | Asn-richAdd BLAST | 28 | |
Compositional biasi | 324 – 361 | Gln-richAdd BLAST | 38 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000170167 |
InParanoidi | P56672 |
OMAi | PNIADLG |
PhylomeDBi | P56672 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR000047, HTH_motif IPR003654, OAR_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform E (identifier: P56672-5) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLNNLGANVL GPKDCDLPKA ALTALHAGVN SFGQLPVGPN LADLGGGAGG
60 70 80 90 100
GGSSGGVPVG GGVARLHISG GLCDNSNALN GGNGSSGNGN GNNNNGNGNN
110 120 130 140 150
NNSMQQQDQK RHRTRFTPAQ LNELERCFSK THYPDIFMRE EIAMRIGLTE
160 170 180 190 200
SRVQVWFQNR RAKWKKRKKT TNVFRTPGAL LPSHGLPPFG ANITNIAMGD
210 220 230 240 250
GLCGTGMFGG DRWSVGVNPM TAGFGQLNQS SPLSSSLNSG LNSGINMGSA
260 270 280 290 300
LGAGSYQHYG LNALGDSMMY QHSVGGVSCG PSGSPSATTP PNMNSCSSVT
310 320 330 340 350
PPPLSAQPNS SQNELNGEPM PLHQQQQQQT HQHQQQQTHQ HHPMAPPTPT
360 370 380 390 400
QQQQQLPQSM QSPSDGANDT LHSIAALRRR ASELNAIPSY LQMAPHNYEH
YNSNSNSVY
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4LG58 | A0A0B4LG58_DROME | Orthopedia, isoform J | otp BcDNA:RE58095, bk24, CG2965, Dmel\CG10036, Otp | 374 | Annotation score: | ||
A0A0B4LH19 | A0A0B4LH19_DROME | Orthopedia, isoform K | otp BcDNA:RE58095, bk24, CG2965, Dmel\CG10036, Otp | 416 | Annotation score: | ||
A0A0B4LG13 | A0A0B4LG13_DROME | Orthopedia, isoform I | otp BcDNA:RE58095, bk24, CG2965, Dmel\CG10036, Otp | 367 | Annotation score: | ||
A0A4P7VNY3 | A0A4P7VNY3_DROME | Orthopedia, isoform L | otp BcDNA:RE58095, bk24, CG2965, Dmel\CG10036, Otp | 381 | Annotation score: | ||
A0A0B4LFU7 | A0A0B4LFU7_DROME | Orthopedia, isoform H | otp BcDNA:RE58095, bk24, CG2965, Dmel\CG10036, Otp | 306 | Annotation score: | ||
A0A0B4LFZ2 | A0A0B4LFZ2_DROME | Orthopedia, isoform F | otp BcDNA:RE58095, bk24, CG2965, Dmel\CG10036, Otp | 313 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026420 | 1 – 96 | Missing in isoform C. 1 PublicationAdd BLAST | 96 | |
Alternative sequenceiVSP_036997 | 97 – 108 | NGNNN…MQQQD → MQQQDQHLDKNK in isoform C. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_036998 | 223 – 264 | Missing in isoform C. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAS64751.3 AE013599 Genomic DNA Translation: ABI31108.1 BT023887 mRNA Translation: ABA81821.1 BT030422 mRNA Translation: ABO52842.1 |
RefSeqi | NP_001036563.1, NM_001043098.2 [P56672-3] NP_001097388.2, NM_001103918.3 [P56672-5] |
Genome annotation databases
EnsemblMetazoai | FBtr0110772; FBpp0110069; FBgn0015524 [P56672-3] FBtr0290289; FBpp0288728; FBgn0015524 [P56672-5] |
GeneIDi | 37364 |
KEGGi | dme:Dmel_CG10036 |
UCSCi | CG10036-RC, d. melanogaster [P56672-5] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAS64751.3 AE013599 Genomic DNA Translation: ABI31108.1 BT023887 mRNA Translation: ABA81821.1 BT030422 mRNA Translation: ABO52842.1 |
RefSeqi | NP_001036563.1, NM_001043098.2 [P56672-3] NP_001097388.2, NM_001103918.3 [P56672-5] |
3D structure databases
SMRi | P56672 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 63008, 18 interactors |
DIPi | DIP-17198N |
IntActi | P56672, 19 interactors |
STRINGi | 7227.FBpp0288728 |
Proteomic databases
PaxDbi | P56672 |
Genome annotation databases
EnsemblMetazoai | FBtr0110772; FBpp0110069; FBgn0015524 [P56672-3] FBtr0290289; FBpp0288728; FBgn0015524 [P56672-5] |
GeneIDi | 37364 |
KEGGi | dme:Dmel_CG10036 |
UCSCi | CG10036-RC, d. melanogaster [P56672-5] |
Organism-specific databases
CTDi | 23440 |
FlyBasei | FBgn0015524, otp |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000170167 |
InParanoidi | P56672 |
OMAi | PNIADLG |
PhylomeDBi | P56672 |
Miscellaneous databases
BioGRID-ORCSi | 37364, 0 hits in 1 CRISPR screen |
ChiTaRSi | otp, fly |
GenomeRNAii | 37364 |
PROi | PR:P56672 |
Gene expression databases
Bgeei | FBgn0015524, Expressed in digestive system element and 31 other tissues |
ExpressionAtlasi | P56672, baseline and differential |
Genevisiblei | P56672, DM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR000047, HTH_motif IPR003654, OAR_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OTP_DROME | |
Accessioni | P56672Primary (citable) accession number: P56672 Secondary accession number(s): A4IJ64 Q9W2Q4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families