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UniProtKB - P56671 (MAZ_MOUSE)
Protein
Myc-associated zinc finger protein
Gene
Maz
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional regulator (By similarity).
Acts as a transcriptional activator that binds to purine-rich GAGA sites found in the promoter of many genes including insulin I and II and islet amyloid polypeptide (PubMed:1454839).
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 190 – 212 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 279 – 301 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 307 – 329 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 337 – 360 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 366 – 388 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 413 | C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST | 22 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
GO - Biological processi
- negative regulation of apoptotic signaling pathway Source: MGI
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of cell migration Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
- positive regulation of protein kinase B signaling Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- termination of RNA polymerase II transcription Source: MGI
- transcription initiation from RNA polymerase II promoter Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Myc-associated zinc finger proteinShort name: MAZI Alternative name(s): Pur-1 Purine-binding transcription factor |
Gene namesi | Name:Maz |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1338823, Maz |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047217 | 1 – 477 | Myc-associated zinc finger proteinAdd BLAST | 477 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 361 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P56671 |
MaxQBi | P56671 |
PaxDbi | P56671 |
PRIDEi | P56671 |
ProteomicsDBi | 295962 |
PTM databases
iPTMneti | P56671 |
PhosphoSitePlusi | P56671 |
Expressioni
Tissue specificityi
Expressed in Purkinje cells in the brain (at protein level).1 Publication
Interactioni
Subunit structurei
Interacts with BPTF.
By similarityBinary interactionsi
P56671
With | #Exp. | IntAct |
---|---|---|
Dcc [P70211] | 3 | EBI-1809712,EBI-1798863 |
FOS [P01100] from Homo sapiens. | 2 | EBI-1809712,EBI-852851 |
JUN [P05412] from Homo sapiens. | 2 | EBI-1809712,EBI-852823 |
Protein-protein interaction databases
IntActi | P56671, 3 interactors |
STRINGi | 10090.ENSMUSP00000032916 |
Miscellaneous databases
RNActi | P56671, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 59 – 78 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 121 – 144 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 128 – 144 | Pro residuesSequence analysisAdd BLAST | 17 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 190 – 212 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 279 – 301 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 307 – 329 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 337 – 360 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 366 – 388 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 413 | C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST | 22 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | P56671 |
PhylomeDBi | P56671 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
P56671-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFPVFPCTLL APPFPVLGLD SRGVGGLMNS FPPPQGHAQN PLQVGAELQS
60 70 80 90 100
RFFASQGCAQ SPFQAAPAPP PTPQAPAAEP LQVDLLPVLA AAQESAAAAA
110 120 130 140 150
AAAAAAAAVV TAPPAPAAAS TVDTAALKQP PAPPPPPPAV SAPAAEAAPP
160 170 180 190 200
AAAATIAAAA ATAVVAPTST VAVAPVASVL EKKTKSKGPY ICALCAKEFK
210 220 230 240 250
NGYNLRRHEA IHTGAKAGRV PSGAMKMPTM VPLSLLSVPQ LSGASGGGGE
260 270 280 290 300
AGAGGGTTAV AAGGVVTTTA SGKRIRKNHA CEMCGKAFRD VYHLNRHKLS
310 320 330 340 350
HSDEKPYQCP VCQQRFKRKD RMSYHVRSHD GAVHKPYNCS HCGKSFSRPD
360 370 380 390 400
HLNSHVRQVH STERPFKCEK CEAAFATKDR LRAHTVRHEE KVPCHVCGKM
410 420 430 440 450
LSSAYISDHM KVHSQGPHHV CELCNKGTGE VCPMAAAAAA AAAAAAAVVA
460 470
APPTAVGSLS GAEGVPVSSQ PLPSQPW
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RNL9 | A0A0U1RNL9_MOUSE | Myc-associated zinc finger protein | Maz | 493 | Annotation score: | ||
F8VPK3 | F8VPK3_MOUSE | Myc-associated zinc finger protein | Maz | 477 | Annotation score: | ||
A0A0U1RNL1 | A0A0U1RNL1_MOUSE | Myc-associated zinc finger protein | Maz | 454 | Annotation score: | ||
A0A0U1RQ66 | A0A0U1RQ66_MOUSE | Myc-associated zinc finger protein | Maz | 109 | Annotation score: | ||
A0A0U1RPH5 | A0A0U1RPH5_MOUSE | Myc-associated zinc finger protein | Maz | 172 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 64 | Q → QQ in BAA76280 (PubMed:10092852).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04649 mRNA No translation available. AB006360 Genomic DNA Translation: BAA76280.1 |
CCDSi | CCDS40137.1 |
PIRi | A47236 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L04649 mRNA No translation available. AB006360 Genomic DNA Translation: BAA76280.1 |
CCDSi | CCDS40137.1 |
PIRi | A47236 |
3D structure databases
SMRi | P56671 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P56671, 3 interactors |
STRINGi | 10090.ENSMUSP00000032916 |
PTM databases
iPTMneti | P56671 |
PhosphoSitePlusi | P56671 |
Proteomic databases
EPDi | P56671 |
MaxQBi | P56671 |
PaxDbi | P56671 |
PRIDEi | P56671 |
ProteomicsDBi | 295962 |
Organism-specific databases
MGIi | MGI:1338823, Maz |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | P56671 |
PhylomeDBi | P56671 |
Miscellaneous databases
ChiTaRSi | Maz, mouse |
PROi | PR:P56671 |
RNActi | P56671, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MAZ_MOUSE | |
Accessioni | P56671Primary (citable) accession number: P56671 Secondary accession number(s): Q9R1W0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 15, 1999 | |
Last modified: | February 23, 2022 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot