UniProtKB - P56638 (CA1A_CONEP)
Protein
Alpha-conotoxin EpI
Gene
N/A
Organism
Conus episcopatus (Bishop's cone)
Status
Functioni
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This peptide blocks mammalian nicotinic acetylcholine receptors composed of alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-3-beta-4/CHRNA3-CHRNB4 subunits.1 Publication
GO - Molecular functioni
- acetylcholine receptor inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-conotoxin EpI2 Publications |
Organismi | Conus episcopatus (Bishop's cone) |
Taxonomic identifieri | 88764 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Conus › Darioconus |
Organism-specific databases
ConoServeri | 405 EpI |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- other organism postsynaptic membrane Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
PropeptideiPRO_0000392692 | 17 – 39 | 1 PublicationAdd BLAST | 23 | |
PeptideiPRO_0000044457 | 40 – 55 | Alpha-conotoxin EpI1 PublicationAdd BLAST | 16 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 41 ↔ 47 | 1 PublicationImported | ||
Disulfide bondi | 42 ↔ 55 | 1 PublicationImported | ||
Modified residuei | 54 | Sulfotyrosine1 Publication | 1 | |
Modified residuei | 55 | Cysteine amide2 Publications | 1 |
Keywords - PTMi
Amidation, Disulfide bond, SulfationExpressioni
Tissue specificityi
Expressed by the venom duct.1 Publication
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A0M | X-ray | 1.10 | A/B | 40-55 | [»] | |
SMRi | P56638 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P56638 |
Family & Domainsi
Domaini
The cysteine framework is I (CC-C-C). Alpha4/7 pattern.Curated
Sequence similaritiesi
Belongs to the conotoxin A superfamily.Curated
Keywords - Domaini
SignalFamily and domain databases
InterProi | View protein in InterPro IPR009958 Conotoxin_a-typ IPR018072 Conotoxin_a-typ_CS |
Pfami | View protein in Pfam PF07365 Toxin_8, 1 hit |
PROSITEi | View protein in PROSITE PS60014 ALPHA_CONOTOXIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P56638-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFTVFLLVVL ATTVVSFTSD RASDSRKDAA SGLIALTIKG CCSDPRCNMN
NPDYCG
Mass spectrometryi
Molecular mass is 1787.02 Da from positions 40 - 55. Determined by ESI. Without sulfation.1 Publication
Molecular mass is 1867.08 Da from positions 40 - 55. Determined by ESI. With sulfation.1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BD261428 Unassigned DNA No translation available. |
PIRi | A59042 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BD261428 Unassigned DNA No translation available. |
PIRi | A59042 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A0M | X-ray | 1.10 | A/B | 40-55 | [»] | |
SMRi | P56638 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Organism-specific databases
ConoServeri | 405 EpI |
Miscellaneous databases
EvolutionaryTracei | P56638 |
Family and domain databases
InterProi | View protein in InterPro IPR009958 Conotoxin_a-typ IPR018072 Conotoxin_a-typ_CS |
Pfami | View protein in Pfam PF07365 Toxin_8, 1 hit |
PROSITEi | View protein in PROSITE PS60014 ALPHA_CONOTOXIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | CA1A_CONEP | |
Accessioni | P56638Primary (citable) accession number: P56638 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | March 23, 2010 | |
Last modified: | September 12, 2018 | |
This is version 73 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references