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Entry version 138 (02 Dec 2020)
Sequence version 1 (15 Dec 1998)
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Protein

Aquaporin-9

Gene

Aqp9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Channel activity is inhibited by mercury ions and phloretin.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-432030, Transport of glycerol from adipocytes to the liver by Aquaporins
R-RNO-432047, Passive transport by Aquaporins

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.8.9.2, the major intrinsic protein (mip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aquaporin-9
Short name:
AQP-9
Alternative name(s):
Aquaglyceroporin-9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aqp9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
68433, Aqp9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27CytoplasmicCuratedAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 48HelicalBy similarityAdd BLAST21
Topological domaini49 – 54ExtracellularCurated6
Transmembranei55 – 75HelicalBy similarityAdd BLAST21
Topological domaini76 – 79CytoplasmicCurated4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei80 – 93Discontinuously helicalBy similarityAdd BLAST14
Topological domaini94 – 99CytoplasmicCurated6
Transmembranei100 – 124HelicalBy similarityAdd BLAST25
Topological domaini125 – 158ExtracellularCuratedAdd BLAST34
Transmembranei159 – 179HelicalBy similarityAdd BLAST21
Topological domaini180 – 189CytoplasmicCurated10
Transmembranei190 – 209HelicalBy similarityAdd BLAST20
Intramembranei210 – 228Discontinuously helicalBy similarityAdd BLAST19
Topological domaini229 – 245ExtracellularCuratedAdd BLAST17
Transmembranei246 – 266HelicalBy similarityAdd BLAST21
Topological domaini267 – 295CytoplasmicCuratedAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000639661 – 295Aquaporin-9Add BLAST295

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56627

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P56627

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P56627

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in testis and liver. Detected in immature spermatocytes and in interstitial Leydig cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000061883, Expressed in liver and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P56627, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000021442

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P56627

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi84 – 86NPA 1By similarity3
Motifi216 – 218NPA 2By similarity3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0224, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160582

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020019_9_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P56627

Identification of Orthologs from Complete Genome Data

More...
OMAi
VFCTYPA

Database of Orthologous Groups

More...
OrthoDBi
1152704at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P56627

TreeFam database of animal gene trees

More...
TreeFami
TF313173

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00333, MIP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1080.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023271, Aquaporin-like
IPR015685, Aquaporin_9
IPR000425, MIP
IPR022357, MIP_CS

The PANTHER Classification System

More...
PANTHERi
PTHR43829:SF6, PTHR43829:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00230, MIP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02021, AQUAPORIN9
PR00783, MINTRINSICP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81338, SSF81338, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00861, MIP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00221, MIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P56627-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSEKDGAKK SLMQRLALKS RIAKETLSEF LGTFIMIVLG CSSIAQAVLS
60 70 80 90 100
RERFGGIITI NIGFASAVVM ALYVTFGISG GHINPAVSFA MCAFGRMEWF
110 120 130 140 150
KFPFYVGAQF LGAFVGAATV FGIYYDGLMA FAGGKLLVVG ENATAFIFAT
160 170 180 190 200
YPAPFISTPG AFVDQVVSTM FLLLIVFAMF DSRNLGVPRG LEPVVIGLLI
210 220 230 240 250
IVLSCSLGLN SGCAMNPARD LSPRLFTALA GWGFEVFTVG NNFWWIPVVG
260 270 280 290
PMIGAFLGGL IYILFIQMHH SKLDPDMKAE PSENNLEKHE LSVIM
Length:295
Mass (Da):31,871
Last modified:December 15, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i09FD8B1DE936E61F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti93A → V in BAA33680 (PubMed:10205677).Curated1
Sequence conflicti197G → S in BAA33680 (PubMed:10205677).Curated1
Sequence conflicti207L → P in BAA33680 (PubMed:10205677).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF016406 mRNA Translation: AAC36020.1
AB013112 mRNA Translation: BAA33680.1
BC085731 mRNA Translation: AAH85731.1

NCBI Reference Sequences

More...
RefSeqi
NP_075249.1, NM_022960.2
XP_006243424.1, XM_006243362.1
XP_008764558.1, XM_008766336.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000087980; ENSRNOP00000069377; ENSRNOG00000061883

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65054

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:65054

UCSC genome browser

More...
UCSCi
RGD:68433, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016406 mRNA Translation: AAC36020.1
AB013112 mRNA Translation: BAA33680.1
BC085731 mRNA Translation: AAH85731.1
RefSeqiNP_075249.1, NM_022960.2
XP_006243424.1, XM_006243362.1
XP_008764558.1, XM_008766336.2

3D structure databases

SMRiP56627
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021442

Protein family/group databases

TCDBi1.A.8.9.2, the major intrinsic protein (mip) family

PTM databases

iPTMnetiP56627
PhosphoSitePlusiP56627

Proteomic databases

PaxDbiP56627

Genome annotation databases

EnsembliENSRNOT00000087980; ENSRNOP00000069377; ENSRNOG00000061883
GeneIDi65054
KEGGirno:65054
UCSCiRGD:68433, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
366
RGDi68433, Aqp9

Phylogenomic databases

eggNOGiKOG0224, Eukaryota
GeneTreeiENSGT00940000160582
HOGENOMiCLU_020019_9_1_1
InParanoidiP56627
OMAiVFCTYPA
OrthoDBi1152704at2759
PhylomeDBiP56627
TreeFamiTF313173

Enzyme and pathway databases

ReactomeiR-RNO-432030, Transport of glycerol from adipocytes to the liver by Aquaporins
R-RNO-432047, Passive transport by Aquaporins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P56627

Gene expression databases

BgeeiENSRNOG00000061883, Expressed in liver and 20 other tissues
GenevisibleiP56627, RN

Family and domain databases

CDDicd00333, MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271, Aquaporin-like
IPR015685, Aquaporin_9
IPR000425, MIP
IPR022357, MIP_CS
PANTHERiPTHR43829:SF6, PTHR43829:SF6, 1 hit
PfamiView protein in Pfam
PF00230, MIP, 1 hit
PRINTSiPR02021, AQUAPORIN9
PR00783, MINTRINSICP
SUPFAMiSSF81338, SSF81338, 1 hit
TIGRFAMsiTIGR00861, MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221, MIP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAQP9_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56627
Secondary accession number(s): O88815
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: December 2, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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