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UniProtKB - P56597 (NDK5_HUMAN)
Protein
Nucleoside diphosphate kinase homolog 5
Gene
NME5
Organism
Homo sapiens (Human)
Status
Functioni
Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 127 | Pros-phosphohistidine intermediateSequence analysis | 1 |
GO - Molecular functioni
- nucleoside diphosphate kinase activity Source: ProtInc
GO - Biological processi
- cilium assembly Source: Ensembl
- CTP biosynthetic process Source: InterPro
- epithelial cilium movement involved in extracellular fluid movement Source: Ensembl
- GTP biosynthetic process Source: InterPro
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: GO_Central
- nucleoside metabolic process Source: ProtInc
- spermatid development Source: UniProtKB
- spermatogenesis Source: ProtInc
- UTP biosynthetic process Source: InterPro
- ventricular system development Source: Ensembl
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Spermatogenesis |
Enzyme and pathway databases
PathwayCommonsi | P56597 |
SignaLinki | P56597 |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleoside diphosphate kinase homolog 5Short name: NDK-H 5 Short name: NDP kinase homolog 5 Alternative name(s): Inhibitor of p53-induced apoptosis-beta Short name: IPIA-beta Testis-specific nm23 homolog nm23-H5 |
Gene namesi | Name:NME5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7853, NME5 |
MIMi | 603575, gene |
neXtProti | NX_P56597 |
VEuPathDBi | HostDB:ENSG00000112981 |
Subcellular locationi
Other locations
- cilium By similarity
Extracellular region or secreted
- extracellular region Source: GOC
Other locations
- cilium Source: UniProtKB
- sperm flagellum Source: Ensembl
Keywords - Cellular componenti
Cell projectionPathology & Biotechi
Organism-specific databases
DisGeNETi | 8382 |
OpenTargetsi | ENSG00000112981 |
PharmGKBi | PA31658 |
Miscellaneous databases
Pharosi | P56597, Tbio |
Genetic variation databases
BioMutai | NME5 |
DMDMi | 3914118 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000137125 | 1 – 212 | Nucleoside diphosphate kinase homolog 5Add BLAST | 212 |
Proteomic databases
MassIVEi | P56597 |
PaxDbi | P56597 |
PeptideAtlasi | P56597 |
PRIDEi | P56597 |
ProteomicsDBi | 56930 |
PTM databases
iPTMneti | P56597 |
PhosphoSitePlusi | P56597 |
Expressioni
Tissue specificityi
Specifically expressed in testis germinal cells.
Gene expression databases
Bgeei | ENSG00000112981, Expressed in bronchial epithelial cell and 185 other tissues |
ExpressionAtlasi | P56597, baseline and differential |
Genevisiblei | P56597, HS |
Organism-specific databases
HPAi | ENSG00000112981, Tissue enhanced (fallopian tube, testis) |
Interactioni
Binary interactionsi
P56597
With | #Exp. | IntAct |
---|---|---|
ATXN1 [P54253] | 3 | EBI-740667,EBI-930964 |
DYDC1 [Q8WWB3] | 8 | EBI-740667,EBI-740680 |
DYDC2 [Q96IM9] | 3 | EBI-740667,EBI-749277 |
HTT [P42858] | 6 | EBI-740667,EBI-466029 |
JPH3 [Q8WXH2] | 3 | EBI-740667,EBI-1055254 |
Protein-protein interaction databases
BioGRIDi | 113972, 11 interactors |
IntActi | P56597, 6 interactors |
MINTi | P56597 |
STRINGi | 9606.ENSP00000265191 |
Miscellaneous databases
RNActi | P56597, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the NDK family.Curated
Phylogenomic databases
eggNOGi | KOG0888, Eukaryota |
GeneTreei | ENSGT00940000159595 |
HOGENOMi | CLU_060216_2_0_1 |
InParanoidi | P56597 |
OMAi | HNAISYW |
OrthoDBi | 1473942at2759 |
PhylomeDBi | P56597 |
TreeFami | TF354225 |
Family and domain databases
Gene3Di | 3.30.70.141, 1 hit |
InterProi | View protein in InterPro IPR007858, Dpy-30_motif IPR034907, NDK-like_dom IPR036850, NDK-like_dom_sf IPR012410, NDK_H5 IPR001564, Nucleoside_diP_kinase |
Pfami | View protein in Pfam PF05186, Dpy-30, 1 hit PF00334, NDK, 1 hit |
PIRSFi | PIRSF036504, NDK_H5, 1 hit |
PRINTSi | PR01243, NUCDPKINASE |
SMARTi | View protein in SMART SM00562, NDK, 1 hit |
SUPFAMi | SSF54919, SSF54919, 1 hit |
i Sequence
Sequence statusi: Complete.
P56597-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEISMPPPQI YVEKTLAIIK PDIVDKEEEI QDIILRSGFT IVQRRKLRLS
60 70 80 90 100
PEQCSNFYVE KYGKMFFPNL TAYMSSGPLV AMILARHKAI SYWLELLGPN
110 120 130 140 150
NSLVAKETHP DSLRAIYGTD DLRNALHGSN DFAAAEREIR FMFPEVIVEP
160 170 180 190 200
IPIGQAAKDY LNLHIMPTLL EGLTELCKQK PADPLIWLAD WLLKNNPNKP
210
KLCHHPIVEE PY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14992 mRNA Translation: CAA75226.1 AF067724 mRNA Translation: AAC64358.1 U90450 mRNA Translation: AAC69440.1 AK312181 mRNA Translation: BAG35114.1 CH471062 Genomic DNA Translation: EAW62164.1 BC026182 mRNA Translation: AAH26182.1 |
CCDSi | CCDS4197.1 |
RefSeqi | NP_003542.1, NM_003551.2 |
Genome annotation databases
Ensembli | ENST00000265191.4; ENSP00000265191.2; ENSG00000112981.5 |
GeneIDi | 8382 |
KEGGi | hsa:8382 |
MANE-Selecti | ENST00000265191.4; ENSP00000265191.2; NM_003551.3; NP_003542.1 |
UCSCi | uc003lce.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14992 mRNA Translation: CAA75226.1 AF067724 mRNA Translation: AAC64358.1 U90450 mRNA Translation: AAC69440.1 AK312181 mRNA Translation: BAG35114.1 CH471062 Genomic DNA Translation: EAW62164.1 BC026182 mRNA Translation: AAH26182.1 |
CCDSi | CCDS4197.1 |
RefSeqi | NP_003542.1, NM_003551.2 |
3D structure databases
AlphaFoldDBi | P56597 |
SMRi | P56597 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113972, 11 interactors |
IntActi | P56597, 6 interactors |
MINTi | P56597 |
STRINGi | 9606.ENSP00000265191 |
PTM databases
iPTMneti | P56597 |
PhosphoSitePlusi | P56597 |
Genetic variation databases
BioMutai | NME5 |
DMDMi | 3914118 |
Proteomic databases
MassIVEi | P56597 |
PaxDbi | P56597 |
PeptideAtlasi | P56597 |
PRIDEi | P56597 |
ProteomicsDBi | 56930 |
Protocols and materials databases
Antibodypediai | 26568, 182 antibodies from 25 providers |
DNASUi | 8382 |
Genome annotation databases
Ensembli | ENST00000265191.4; ENSP00000265191.2; ENSG00000112981.5 |
GeneIDi | 8382 |
KEGGi | hsa:8382 |
MANE-Selecti | ENST00000265191.4; ENSP00000265191.2; NM_003551.3; NP_003542.1 |
UCSCi | uc003lce.4, human |
Organism-specific databases
CTDi | 8382 |
DisGeNETi | 8382 |
GeneCardsi | NME5 |
HGNCi | HGNC:7853, NME5 |
HPAi | ENSG00000112981, Tissue enhanced (fallopian tube, testis) |
MIMi | 603575, gene |
neXtProti | NX_P56597 |
OpenTargetsi | ENSG00000112981 |
PharmGKBi | PA31658 |
VEuPathDBi | HostDB:ENSG00000112981 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0888, Eukaryota |
GeneTreei | ENSGT00940000159595 |
HOGENOMi | CLU_060216_2_0_1 |
InParanoidi | P56597 |
OMAi | HNAISYW |
OrthoDBi | 1473942at2759 |
PhylomeDBi | P56597 |
TreeFami | TF354225 |
Enzyme and pathway databases
PathwayCommonsi | P56597 |
SignaLinki | P56597 |
Miscellaneous databases
BioGRID-ORCSi | 8382, 14 hits in 1068 CRISPR screens |
ChiTaRSi | NME5, human |
GenomeRNAii | 8382 |
Pharosi | P56597, Tbio |
PROi | PR:P56597 |
RNActi | P56597, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112981, Expressed in bronchial epithelial cell and 185 other tissues |
ExpressionAtlasi | P56597, baseline and differential |
Genevisiblei | P56597, HS |
Family and domain databases
Gene3Di | 3.30.70.141, 1 hit |
InterProi | View protein in InterPro IPR007858, Dpy-30_motif IPR034907, NDK-like_dom IPR036850, NDK-like_dom_sf IPR012410, NDK_H5 IPR001564, Nucleoside_diP_kinase |
Pfami | View protein in Pfam PF05186, Dpy-30, 1 hit PF00334, NDK, 1 hit |
PIRSFi | PIRSF036504, NDK_H5, 1 hit |
PRINTSi | PR01243, NUCDPKINASE |
SMARTi | View protein in SMART SM00562, NDK, 1 hit |
SUPFAMi | SSF54919, SSF54919, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NDK5_HUMAN | |
Accessioni | P56597Primary (citable) accession number: P56597 Secondary accession number(s): B2R5G7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | December 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families