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Entry version 179 (29 Sep 2021)
Sequence version 1 (15 Dec 1998)
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Protein

Peroxisomal biogenesis factor 3

Gene

PEX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeroxisome biogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P56589

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1369062, ABC transporters in lipid homeostasis
R-HSA-9603798, Class I peroxisomal membrane protein import

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P56589

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.17.1.2, the integral membrane peroxisomal protein importer-2 (ppi2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisomal biogenesis factor 3
Alternative name(s):
Peroxin-3
Peroxisomal assembly protein PEX3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PEX3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8858, PEX3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603164, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P56589

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000034693

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 116PeroxisomalSequence analysisAdd BLAST80
Transmembranei117 – 140HelicalSequence analysisAdd BLAST24
Topological domaini141 – 373CytoplasmicSequence analysisAdd BLAST233

Keywords - Cellular componenti

Membrane, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Peroxisome biogenesis disorder complementation group 12 (PBD-CG12)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS).
Related information in OMIM
Peroxisome biogenesis disorder 10A (PBD10A)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA fatal peroxisome biogenesis disorder belonging to the Zellweger disease spectrum and clinically characterized by severe neurologic dysfunction with profound psychomotor retardation, severe hypotonia and neonatal seizures, craniofacial abnormalities, liver dysfunction, and biochemically by the absence of peroxisomes. Additional features include cardiovascular and skeletal defects, renal cysts, ocular abnormalities, and hearing impairment. Most severely affected individuals with the classic form of the disease (classic Zellweger syndrome) die within the first year of life.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_009304138G → E in PBD10A. 1 Publication1
Peroxisome biogenesis disorder 10B (PBD10B)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA moderately severe peroxisome biogenesis disorder belonging to the Zellweger disease spectrum. PBD10B is characterized by neonatal jaundice, dysmorphic features, delayed psychomotor development, axial hypotonia that can progress to severe spastic paraparesis with hyperreflexia, nephrocalcinosis, neurogenic bladder, nystagmus, and cataracts. Laboratory studies show increased levels of very long-chain fatty acids. Inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078657331G → R in PBD10B. 1 PublicationCorresponds to variant dbSNP:rs1057523689EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi125L → P: Abolishes binding to PEX19 without affecting targeting to peroxisomes; when associated with D-134. 1 Publication1
Mutagenesisi134N → D: Abolishes binding to PEX19 without affecting targeting to peroxisomes; when associated with P-125. 1 Publication1

Keywords - Diseasei

Disease variant, Peroxisome biogenesis disorder, Zellweger syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
8504

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
PEX3

MalaCards human disease database

More...
MalaCardsi
PEX3
MIMi614882, phenotype
617370, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000034693

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
772, Infantile Refsum disease
44, Neonatal adrenoleukodystrophy
912, Zellweger syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33200

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P56589, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PEX3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3914303

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002087371 – 373Peroxisomal biogenesis factor 3Add BLAST373

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P56589

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P56589

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P56589

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56589

PeptideAtlas

More...
PeptideAtlasi
P56589

PRoteomics IDEntifications database

More...
PRIDEi
P56589

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56929

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P56589

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P56589

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in all examined tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000034693, Expressed in adrenal tissue and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P56589, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P56589, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000034693, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PEX19.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114076, 16 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P56589

Protein interaction database and analysis system

More...
IntActi
P56589, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356563

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P56589, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1373
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P56589

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P56589

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 45Targeting to peroxisomes1 PublicationAdd BLAST45
Regioni120 – 136Interaction with PEX191 PublicationAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxin-3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4444, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008481

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041367_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P56589

Identification of Orthologs from Complete Genome Data

More...
OMAi
WSLQMAI

Database of Orthologous Groups

More...
OrthoDBi
891261at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P56589

TreeFam database of animal gene trees

More...
TreeFami
TF352826

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006966, Peroxin-3

The PANTHER Classification System

More...
PANTHERi
PTHR28080, PTHR28080, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04882, Peroxin-3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P56589-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRSVWNFLK RHKKKCIFLG TVLGGVYILG KYGQKKIREI QEREAAEYIA
60 70 80 90 100
QARRQYHFES NQRTCNMTVL SMLPTLREAL MQQLNSESLT ALLKNRPSNK
110 120 130 140 150
LEIWEDLKII SFTRSTVAVY STCMLVVLLR VQLNIIGGYI YLDNAAVGKN
160 170 180 190 200
GTTILAPPDV QQQYLSSIQH LLGDGLTELI TVIKQAVQKV LGSVSLKHSL
210 220 230 240 250
SLLDLEQKLK EIRNLVEQHK SSSWINKDGS KPLLCHYMMP DEETPLAVQA
260 270 280 290 300
CGLSPRDITT IKLLNETRDM LESPDFSTVL NTCLNRGFSR LLDNMAEFFR
310 320 330 340 350
PTEQDLQHGN SMNSLSSVSL PLAKIIPIVN GQIHSVCSET PSHFVQDLLT
360 370
MEQVKDFAAN VYEAFSTPQQ LEK
Length:373
Mass (Da):42,140
Last modified:December 15, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3515A1F29656B7CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z6V3Q7Z6V3_HUMAN
Peroxisomal assembly protein PEX3
PEX3
182Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05357282Q → R. Corresponds to variant dbSNP:rs35220041EnsemblClinVar.1
Natural variantiVAR_009304138G → E in PBD10A. 1 Publication1
Natural variantiVAR_078657331G → R in PBD10B. 1 PublicationCorresponds to variant dbSNP:rs1057523689EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ001625 mRNA Translation: CAA04879.1
AJ131389 mRNA Translation: CAA10362.1
AJ009866 AJ009874 Genomic DNA Translation: CAA08904.1
AB035307 mRNA Translation: BAA97993.1
AY277600 mRNA Translation: AAQ18039.1
CR542062 mRNA Translation: CAG46859.1
AL031320 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47866.1
BC014551 mRNA Translation: AAH14551.1
BC015506 mRNA Translation: AAH15506.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5199.1

NCBI Reference Sequences

More...
RefSeqi
NP_003621.1, NM_003630.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367591; ENSP00000356563; ENSG00000034693

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8504

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8504

UCSC genome browser

More...
UCSCi
uc003qjl.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001625 mRNA Translation: CAA04879.1
AJ131389 mRNA Translation: CAA10362.1
AJ009866 AJ009874 Genomic DNA Translation: CAA08904.1
AB035307 mRNA Translation: BAA97993.1
AY277600 mRNA Translation: AAQ18039.1
CR542062 mRNA Translation: CAG46859.1
AL031320 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47866.1
BC014551 mRNA Translation: AAH14551.1
BC015506 mRNA Translation: AAH15506.1
CCDSiCCDS5199.1
RefSeqiNP_003621.1, NM_003630.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AJBX-ray2.50A49-373[»]
3MK4X-ray2.42A41-373[»]
SMRiP56589
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114076, 16 interactors
ELMiP56589
IntActiP56589, 8 interactors
STRINGi9606.ENSP00000356563

Protein family/group databases

TCDBi9.A.17.1.2, the integral membrane peroxisomal protein importer-2 (ppi2) family

PTM databases

iPTMnetiP56589
PhosphoSitePlusiP56589

Genetic variation databases

BioMutaiPEX3
DMDMi3914303

Proteomic databases

EPDiP56589
jPOSTiP56589
MassIVEiP56589
PaxDbiP56589
PeptideAtlasiP56589
PRIDEiP56589
ProteomicsDBi56929

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33142, 130 antibodies

The DNASU plasmid repository

More...
DNASUi
8504

Genome annotation databases

EnsembliENST00000367591; ENSP00000356563; ENSG00000034693
GeneIDi8504
KEGGihsa:8504
UCSCiuc003qjl.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8504
DisGeNETi8504

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PEX3
GeneReviewsiPEX3
HGNCiHGNC:8858, PEX3
HPAiENSG00000034693, Low tissue specificity
MalaCardsiPEX3
MIMi603164, gene
614882, phenotype
617370, phenotype
neXtProtiNX_P56589
OpenTargetsiENSG00000034693
Orphaneti772, Infantile Refsum disease
44, Neonatal adrenoleukodystrophy
912, Zellweger syndrome
PharmGKBiPA33200
VEuPathDBiHostDB:ENSG00000034693

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4444, Eukaryota
GeneTreeiENSGT00390000008481
HOGENOMiCLU_041367_2_0_1
InParanoidiP56589
OMAiWSLQMAI
OrthoDBi891261at2759
PhylomeDBiP56589
TreeFamiTF352826

Enzyme and pathway databases

PathwayCommonsiP56589
ReactomeiR-HSA-1369062, ABC transporters in lipid homeostasis
R-HSA-9603798, Class I peroxisomal membrane protein import
SIGNORiP56589

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8504, 31 hits in 1022 CRISPR screens
EvolutionaryTraceiP56589

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PEX3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8504
PharosiP56589, Tbio

Protein Ontology

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PROi
PR:P56589
RNActiP56589, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000034693, Expressed in adrenal tissue and 238 other tissues
ExpressionAtlasiP56589, baseline and differential
GenevisibleiP56589, HS

Family and domain databases

InterProiView protein in InterPro
IPR006966, Peroxin-3
PANTHERiPTHR28080, PTHR28080, 1 hit
PfamiView protein in Pfam
PF04882, Peroxin-3, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEX3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56589
Secondary accession number(s): Q6FGP5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: September 29, 2021
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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