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Entry version 151 (07 Apr 2021)
Sequence version 2 (01 May 2013)
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Protein

G/T mismatch-specific thymine DNA glycosylase

Gene

Tdg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine (PubMed:21817016). Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC (PubMed:21722948). Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine. EC:3.2.2.29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Hydrolase
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-110329, Cleavage of the damaged pyrimidine
R-MMU-110357, Displacement of DNA glycosylase by APEX1
R-MMU-3108214, SUMOylation of DNA damage response and repair proteins
R-MMU-5221030, TET1,2,3 and TDG demethylate DNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G/T mismatch-specific thymine DNA glycosylase (EC:3.2.2.29)
Alternative name(s):
C-JUN leucine zipper interactive protein JZA-3
Thymine-DNA glycosylase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tdg
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108247, Tdg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality between embryonic day (E) 10.5 and E12.5. Embryos display specific patterning defects of the developing heart; vasculogenesis defects of dorsal aortae, carotid arteries and branchial arteries. Global defects of angiogenesis are also oberved. Defects are due to epigenetic aberrations affecting the expression of developmental genes, coincident with imbalanced histone modification and CpG methylation at promoters of affected genes.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi151N → A: Loss of DNA glycosylase activity. 3 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001857781 – 421G/T mismatch-specific thymine DNA glycosylaseAdd BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki259Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki341Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki341Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylation on Lys-341 by either SUMO1 or SUMO2 induces dissociation of the product DNA.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56581

PeptideAtlas

More...
PeptideAtlasi
P56581

PRoteomics IDEntifications database

More...
PRIDEi
P56581

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
263026 [P56581-1]
263027 [P56581-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P56581

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P56581

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034674, Expressed in ganglionic eminence and 91 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P56581, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with AICDA and GADD45A (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
204088, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-216N

Protein interaction database and analysis system

More...
IntActi
P56581, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000121000

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P56581, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P56581

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4120, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000987

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_045775_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P56581

Identification of Orthologs from Complete Genome Data

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OMAi
AVPNMEM

Database of Orthologous Groups

More...
OrthoDBi
1209629at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P56581

TreeFam database of animal gene trees

More...
TreeFami
TF328764

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10028, UDG-F2_TDG_MUG, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.470.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015637, MUG/TDG
IPR003310, TDG-like_euk
IPR005122, Uracil-DNA_glycosylase-like
IPR036895, Uracil-DNA_glycosylase-like_sf

The PANTHER Classification System

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PANTHERi
PTHR12159, PTHR12159, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03167, UDG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52141, SSF52141, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00584, mug, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P56581-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAEAARSYS LEQVQALYSF PFQQMMAEVP NMAVTTGQQV PAVAPNMATV
60 70 80 90 100
TEQQVPEDAP VQEPAPEAPK RRKRKPRAAE PQEPVEPKKP ATSKKSGKST
110 120 130 140 150
KSKEKQEKIT DAFKVKRKVD RFNGVSEAEL LTKTLPDILT FNLDIVIIGI
160 170 180 190 200
NPGLMAAYKG HHYPGPGNHF WKCLFMSGLS EVQLNHMDDH TLPGKYGIGF
210 220 230 240 250
TNMVERTTPG SKDLSSKEFR EGGRILVQKL QKYQPRIAVF NGKCIYEIFS
260 270 280 290 300
KEVFGVKVKN LEFGLQPHKI PDTETLCYVM PSSSARCAQF PRAQDKVHYY
310 320 330 340 350
IKLKDLRDQL KGIERNADVQ EVQYTFDLQL AQEDAKKMAV KEEKYDPGYE
360 370 380 390 400
AAYGGAYGEN PCNGEPCGIA SNGLTAHSAE PRGEAAPSDV PNGQWMAQSF
410 420
AEQIPSFNNC GTREQEEESH A
Length:421
Mass (Da):46,879
Last modified:May 1, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA91BB0A5911933BC
GO
Isoform 2 (identifier: P56581-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Show »
Length:397
Mass (Da):44,117
Checksum:i51205551C2046AB5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJJ4H3BJJ4_MOUSE
G/T mismatch-specific thymine DNA g...
Tdg
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z417D3Z417_MOUSE
G/T mismatch-specific thymine DNA g...
Tdg
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BL22H3BL22_MOUSE
G/T mismatch-specific thymine DNA g...
Tdg
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLR1H3BLR1_MOUSE
G/T mismatch-specific thymine DNA g...
Tdg
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57E → A in AAC31900 (PubMed:9694815).Curated1
Sequence conflicti57E → A in BAC40994 (PubMed:16141072).Curated1
Sequence conflicti57E → A in BAE41355 (PubMed:16141072).Curated1
Sequence conflicti57E → A in EDL04997 (Ref. 4) Curated1
Sequence conflicti57E → A in AAH10315 (PubMed:15489334).Curated1
Sequence conflicti216S → I in AAH85470 (PubMed:15489334).Curated1
Sequence conflicti232K → E in BAC35566 (PubMed:16141072).Curated1
Sequence conflicti317A → T in AAC31900 (PubMed:9694815).Curated1
Sequence conflicti317A → T in BAC40994 (PubMed:16141072).Curated1
Sequence conflicti317A → T in BAE41355 (PubMed:16141072).Curated1
Sequence conflicti317A → T in EDL04997 (Ref. 4) Curated1
Sequence conflicti317A → T in AAH10315 (PubMed:15489334).Curated1
Sequence conflicti386 – 388APS → TPG in AAC31900 (PubMed:9694815).Curated3
Sequence conflicti386 – 388APS → TPG in BAC40994 (PubMed:16141072).Curated3
Sequence conflicti386 – 388APS → TPG in BAE41355 (PubMed:16141072).Curated3
Sequence conflicti386 – 388APS → TPG in EDL04997 (Ref. 4) Curated3
Sequence conflicti386 – 388APS → TPG in AAH10315 (PubMed:15489334).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0464911 – 24Missing in isoform 2. 2 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF069519 mRNA Translation: AAC31900.1
AK053870 mRNA Translation: BAC35566.1
AK089915 mRNA Translation: BAC40994.1
AK164090 mRNA Translation: BAE37621.1
AK164643 mRNA Translation: BAE37857.1
AK169768 mRNA Translation: BAE41355.1
AC152980 Genomic DNA No translation available.
CH466540 Genomic DNA Translation: EDL04997.1
BC010315 mRNA Translation: AAH10315.2
BC085470 mRNA Translation: AAH85470.1
BC085471 mRNA Translation: AAH85471.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS24070.1 [P56581-1]
CCDS36013.1 [P56581-2]

Protein sequence database of the Protein Information Resource

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PIRi
A46132

NCBI Reference Sequences

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RefSeqi
NP_035691.2, NM_011561.2 [P56581-2]
NP_766140.2, NM_172552.3 [P56581-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000092266; ENSMUSP00000089917; ENSMUSG00000034674 [P56581-2]
ENSMUST00000151390; ENSMUSP00000121000; ENSMUSG00000034674 [P56581-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
21665

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:21665

UCSC genome browser

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UCSCi
uc007gjr.2, mouse [P56581-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069519 mRNA Translation: AAC31900.1
AK053870 mRNA Translation: BAC35566.1
AK089915 mRNA Translation: BAC40994.1
AK164090 mRNA Translation: BAE37621.1
AK164643 mRNA Translation: BAE37857.1
AK169768 mRNA Translation: BAE41355.1
AC152980 Genomic DNA No translation available.
CH466540 Genomic DNA Translation: EDL04997.1
BC010315 mRNA Translation: AAH10315.2
BC085470 mRNA Translation: AAH85470.1
BC085471 mRNA Translation: AAH85471.1
CCDSiCCDS24070.1 [P56581-1]
CCDS36013.1 [P56581-2]
PIRiA46132
RefSeqiNP_035691.2, NM_011561.2 [P56581-2]
NP_766140.2, NM_172552.3 [P56581-1]

3D structure databases

SMRiP56581
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi204088, 6 interactors
DIPiDIP-216N
IntActiP56581, 2 interactors
STRINGi10090.ENSMUSP00000121000

PTM databases

iPTMnetiP56581
PhosphoSitePlusiP56581

Proteomic databases

PaxDbiP56581
PeptideAtlasiP56581
PRIDEiP56581
ProteomicsDBi263026 [P56581-1]
263027 [P56581-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30563, 401 antibodies

Genome annotation databases

EnsembliENSMUST00000092266; ENSMUSP00000089917; ENSMUSG00000034674 [P56581-2]
ENSMUST00000151390; ENSMUSP00000121000; ENSMUSG00000034674 [P56581-1]
GeneIDi21665
KEGGimmu:21665
UCSCiuc007gjr.2, mouse [P56581-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6996
MGIiMGI:108247, Tdg

Phylogenomic databases

eggNOGiKOG4120, Eukaryota
GeneTreeiENSGT00390000000987
HOGENOMiCLU_045775_1_0_1
InParanoidiP56581
OMAiAVPNMEM
OrthoDBi1209629at2759
PhylomeDBiP56581
TreeFamiTF328764

Enzyme and pathway databases

ReactomeiR-MMU-110329, Cleavage of the damaged pyrimidine
R-MMU-110357, Displacement of DNA glycosylase by APEX1
R-MMU-3108214, SUMOylation of DNA damage response and repair proteins
R-MMU-5221030, TET1,2,3 and TDG demethylate DNA

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
21665, 4 hits in 54 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tdg, mouse

Protein Ontology

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PROi
PR:P56581
RNActiP56581, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034674, Expressed in ganglionic eminence and 91 other tissues
GenevisibleiP56581, MM

Family and domain databases

CDDicd10028, UDG-F2_TDG_MUG, 1 hit
Gene3Di3.40.470.10, 1 hit
InterProiView protein in InterPro
IPR015637, MUG/TDG
IPR003310, TDG-like_euk
IPR005122, Uracil-DNA_glycosylase-like
IPR036895, Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR12159, PTHR12159, 1 hit
PfamiView protein in Pfam
PF03167, UDG, 1 hit
SUPFAMiSSF52141, SSF52141, 1 hit
TIGRFAMsiTIGR00584, mug, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDG_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56581
Secondary accession number(s): Q3TPW4
, Q542A9, Q5U3M4, Q5U3M5, Q6PJW4, Q8BPK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 2013
Last modified: April 7, 2021
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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