UniProtKB - P56579 (PTHC_ECOLI)
Protein
PTS system glucitol/sorbitol-specific EIIC component
Gene
srlA
Organism
Escherichia coli (strain K12)
Status
Functioni
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol/sorbitol transport. It can also use D-mannitol.1 Publication
GO - Biological processi
Keywordsi
Biological process | Phosphotransferase system, Sugar transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:G8210-MONOMER MetaCyc:G8210-MONOMER |
Protein family/group databases
TCDBi | 4.A.4.1.1, the pts glucitol (gut) family |
Names & Taxonomyi
Protein namesi | Recommended name: PTS system glucitol/sorbitol-specific EIIC component1 PublicationAlternative name(s): EIIC-Gut1 Publication Glucitol/sorbitol permease IIC component1 Publication |
Gene namesi | Name:srlA Synonyms:gutA, sbl Ordered Locus Names:b2702, JW5429 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane PROSITE-ProRule annotation1 Publication; Multi-pass membrane protein PROSITE-ProRule annotation1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 28 | PeriplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 29 – 49 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 50 – 67 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 68 – 88 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 89 – 131 | PeriplasmicSequence analysisAdd BLAST | 43 | |
Transmembranei | 132 – 152 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 153 – 187 | CytoplasmicSequence analysisAdd BLAST | 35 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186565 | 1 – 187 | PTS system glucitol/sorbitol-specific EIIC componentAdd BLAST | 187 |
Proteomic databases
PaxDbi | P56579 |
PRIDEi | P56579 |
Expressioni
Inductioni
Regulated by an unusual system which consists of the activator GutM and the repressor GutR in addition to the cAMP-CRP complex.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262078, 18 interactors 851891, 1 interactor |
IntActi | P56579, 1 interactor |
STRINGi | 511145.b2702 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 187 | PTS EIIC type-5PROSITE-ProRule annotationAdd BLAST | 187 |
Domaini
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG3730, Bacteria |
HOGENOMi | CLU_093147_0_0_6 |
InParanoidi | P56579 |
PhylomeDBi | P56579 |
Family and domain databases
InterProi | View protein in InterPro IPR004699, PTS_IID_sorb |
PANTHERi | PTHR40399, PTHR40399, 1 hit |
Pfami | View protein in Pfam PF03608, EII-GUT, 1 hit |
PIRSFi | PIRSF038321, PTS_glc_srb_IIC, 1 hit |
TIGRFAMsi | TIGR00821, EII-GUT, 1 hit |
PROSITEi | View protein in PROSITE PS51107, PTS_EIIC_TYPE_5, 1 hit |
i Sequence
Sequence statusi: Complete.
P56579-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIETITHGAE WFIGLFQKGG EVFTGMVTGI LPLLISLLVI MNALINFIGQ
60 70 80 90 100
HRIERFAQRC AGNPVSRYLL LPCIGTFVFC NPMTLSLGRF MPEKYKPSYY
110 120 130 140 150
AAASYSCHSM NGLFPHINPG ELFVYLGIAS GLTTLNLPLG PLAVSYLLVG
160 170 180
LVTNFFRGWV TDLTTAIFEK KMGIQLEQKV HLAGATS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02708 Genomic DNA Translation: AAC13411.1 U00096 Genomic DNA Translation: AAT48148.1 AP009048 Genomic DNA Translation: BAA18886.2 X70016 Genomic DNA Translation: CAA49614.1 |
PIRi | A26725, WQEC2S |
RefSeqi | WP_000573321.1, NZ_SSZK01000017.1 YP_026180.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAT48148; AAT48148; b2702 BAA18886; BAA18886; BAA18886 |
GeneIDi | 48726480 947575 |
KEGGi | ecj:JW5429 eco:b2702 |
PATRICi | fig|1411691.4.peg.4040 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02708 Genomic DNA Translation: AAC13411.1 U00096 Genomic DNA Translation: AAT48148.1 AP009048 Genomic DNA Translation: BAA18886.2 X70016 Genomic DNA Translation: CAA49614.1 |
PIRi | A26725, WQEC2S |
RefSeqi | WP_000573321.1, NZ_SSZK01000017.1 YP_026180.1, NC_000913.3 |
3D structure databases
SMRi | P56579 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262078, 18 interactors 851891, 1 interactor |
IntActi | P56579, 1 interactor |
STRINGi | 511145.b2702 |
Protein family/group databases
TCDBi | 4.A.4.1.1, the pts glucitol (gut) family |
Proteomic databases
PaxDbi | P56579 |
PRIDEi | P56579 |
Genome annotation databases
EnsemblBacteriai | AAT48148; AAT48148; b2702 BAA18886; BAA18886; BAA18886 |
GeneIDi | 48726480 947575 |
KEGGi | ecj:JW5429 eco:b2702 |
PATRICi | fig|1411691.4.peg.4040 |
Organism-specific databases
EchoBASEi | EB0962 |
Phylogenomic databases
eggNOGi | COG3730, Bacteria |
HOGENOMi | CLU_093147_0_0_6 |
InParanoidi | P56579 |
PhylomeDBi | P56579 |
Enzyme and pathway databases
BioCyci | EcoCyc:G8210-MONOMER MetaCyc:G8210-MONOMER |
Miscellaneous databases
PROi | PR:P56579 |
Family and domain databases
InterProi | View protein in InterPro IPR004699, PTS_IID_sorb |
PANTHERi | PTHR40399, PTHR40399, 1 hit |
Pfami | View protein in Pfam PF03608, EII-GUT, 1 hit |
PIRSFi | PIRSF038321, PTS_glc_srb_IIC, 1 hit |
TIGRFAMsi | TIGR00821, EII-GUT, 1 hit |
PROSITEi | View protein in PROSITE PS51107, PTS_EIIC_TYPE_5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTHC_ECOLI | |
Accessioni | P56579Primary (citable) accession number: P56579 Secondary accession number(s): P05705, P78102, P78214 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | December 15, 1998 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |