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UniProtKB - P56578 (MALF3_MALFU)
Protein
Putative peroxiredoxin
Gene
N/A
Organism
Malassezia furfur (Pityriasis versicolor infection agent) (Pityrosporum furfur)
Status
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
By similarityMiscellaneous
The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys Prx, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.By similarity
Catalytic activityi
- EC:1.11.1.24By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 56 | Cysteine sulfenic acid (-SOH) intermediateBy similarity | 1 |
GO - Molecular functioni
- peroxidase activity Source: UniProtKB-KW
- peroxiredoxin activity Source: UniProtKB-EC
Keywordsi
Molecular function | Antioxidant, Oxidoreductase, Peroxidase |
Names & Taxonomyi
Protein namesi | Recommended name: Putative peroxiredoxin (EC:1.11.1.24By similarity)Alternative name(s): MF2 Thioredoxin reductase Thioredoxin-dependent peroxiredoxinCurated Allergen: Mal f 3 |
Organismi | Malassezia furfur (Pityriasis versicolor infection agent) (Pityrosporum furfur) |
Taxonomic identifieri | 55194 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Basidiomycota › Ustilaginomycotina › Malasseziomycetes › Malasseziales › Malasseziaceae › Malassezia |
Pathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human.1 Publication
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 3362, Mala f 3.0101 469, Mala f 3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056607 | ‹1 – 166 | Putative peroxiredoxinAdd BLAST | ›166 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 | Interchain (with C-56); in linked formBy similarity | ||
Disulfide bondi | 56 | Interchain (with C-26); in linked formBy similarity |
Keywords - PTMi
Disulfide bondInteractioni
Subunit structurei
Homodimer; disulfide-linked, upon oxidation.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | ‹1 – 166 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | ›166 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 164 – 166 | Microbody targeting signalBy similarity | 3 |
Sequence similaritiesi
Keywords - Domaini
Redox-active centerFamily and domain databases
CDDi | cd03013, PRX5_like, 1 hit |
InterProi | View protein in InterPro IPR037944, PRX5-like IPR013740, Redoxin IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR10430, PTHR10430, 1 hit |
Pfami | View protein in Pfam PF08534, Redoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
P56578-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
EIGSTIPNAT FAYVPYSPEL EDHKVCGMPT SFQSHERWKG KKVVIVAVPG
60 70 80 90 100
AFTPTCTANH VPPYVEKIQE LKSKGVDEVV VISANDPFVL SAWGITEHAK
110 120 130 140 150
DNLTFAQDVN CEFSKHFNAT LDLSSKGMGL RTARYALIAN DLKVEYFGID
160
EGEPKQSSAA TVLSKL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011805 mRNA Translation: BAA32436.1 |
PIRi | JE0227 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011805 mRNA Translation: BAA32436.1 |
PIRi | JE0227 |
3D structure databases
SMRi | P56578 |
ModBasei | Search... |
Protein family/group databases
Allergomei | 3362, Mala f 3.0101 469, Mala f 3 |
Family and domain databases
CDDi | cd03013, PRX5_like, 1 hit |
InterProi | View protein in InterPro IPR037944, PRX5-like IPR013740, Redoxin IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR10430, PTHR10430, 1 hit |
Pfami | View protein in Pfam PF08534, Redoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MALF3_MALFU | |
Accessioni | P56578Primary (citable) accession number: P56578 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | December 15, 1998 | |
Last modified: | September 29, 2021 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Documents
- Allergens
Nomenclature of allergens and list of entries - SIMILARITY comments
Index of protein domains and families