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Entry version 180 (12 Aug 2020)
Sequence version 4 (20 Jun 2018)
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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Gene

NDUFA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly (PubMed:30245030). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P56556

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-611105, Respiratory electron transport
R-HSA-6799198, Complex I biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6Curated
Alternative name(s):
Complex I-B14
Short name:
CI-B14
LYR motif-containing protein 6
NADH-ubiquinone oxidoreductase B14 subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDUFA6Imported
Synonyms:LYRM6, NADHB14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000184983.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7690, NDUFA6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602138, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P56556

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial complex I deficiency, nuclear type 33 (MC1DN33)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mitochondrial complex I deficiency, the most common biochemical signature of mitochondrial disorders, a group of highly heterogeneous conditions characterized by defective oxidative phosphorylation, which collectively affects 1 in 5-10000 live births. Clinical disorders have variable severity, ranging from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. MC1DN33 transmission pattern is consistent with autosomal recessive inheritance.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08147064R → P in MC1DN33. 1 Publication1
Natural variantiVAR_08147189 – 128Missing in MC1DN33. 1 PublicationAdd BLAST40

Keywords - Diseasei

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
4700

MalaCards human disease database

More...
MalaCardsi
NDUFA6
MIMi618253, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000184983

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2609, Isolated complex I deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31496

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P56556, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2363065

Drug and drug target database

More...
DrugBanki
DB00157, NADH

DrugCentral

More...
DrugCentrali
P56556

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NDUFA6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
298286909

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001743021 – 128NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P56556

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P56556

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P56556

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56556

PeptideAtlas

More...
PeptideAtlasi
P56556

PRoteomics IDEntifications database

More...
PRIDEi
P56556

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56926

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P56556

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P56556

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P56556

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184983, Expressed in heart left ventricle and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P56556, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P56556, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184983, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Mammalian complex I is composed of 45 different subunits.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110780, 39 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-577, Mitochondrial respiratory chain complex I

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P56556

Protein interaction database and analysis system

More...
IntActi
P56556, 63 interactors

Molecular INTeraction database

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MINTi
P56556

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000418842

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P56556, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P56556

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3426, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000018898

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P56556

KEGG Orthology (KO)

More...
KOi
K03950

Database of Orthologous Groups

More...
OrthoDBi
1518948at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P56556

TreeFam database of animal gene trees

More...
TreeFami
TF105625

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008011, Complex1_LYR
IPR016488, NADH_Ub_cplx-1_asu_su-6

The PANTHER Classification System

More...
PANTHERi
PTHR12964, PTHR12964, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05347, Complex1_LYR, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006643, NDUA6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P56556-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGSGVRQAT STASTFVKPI FSRDMNEAKR RVRELYRAWY REVPNTVHQF
60 70 80 90 100
QLDITVKMGR DKVREMFMKN AHVTDPRVVD LLVIKGKIEL EETIKVWKQR
110 120
THVMRFFHET EAPRPKDFLS KFYVGHDP
Length:128
Mass (Da):15,137
Last modified:June 20, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5EE10C571A659D8B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Y9D025A0A2Y9D025_HUMAN
Complex I-B14
NDUFA6
154Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN43R4GN43_HUMAN
Complex I-B14
NDUFA6
71Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAG30415 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6V → F in CAG32995 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0144839A → V1 PublicationCorresponds to variant dbSNP:rs1801311Ensembl.1
Natural variantiVAR_08147064R → P in MC1DN33. 1 Publication1
Natural variantiVAR_08147189 – 128Missing in MC1DN33. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF047182 mRNA Translation: AAC04267.1
CR456529 mRNA Translation: CAG30415.1 Different initiation.
AK291874 mRNA Translation: BAF84563.1
AK316562 mRNA Translation: BAG38151.1
CR456714 mRNA Translation: CAG32995.1
CR541997 mRNA Translation: CAG46794.1
AL021878 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60489.1
BC002772 mRNA Translation: AAH02772.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33656.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5821

NCBI Reference Sequences

More...
RefSeqi
NP_002481.2, NM_002490.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000498737; ENSP00000418842; ENSG00000184983
ENST00000605916; ENSP00000475402; ENSG00000272765
ENST00000628740; ENSP00000486781; ENSG00000277365
ENST00000630201; ENSP00000487431; ENSG00000281013
ENST00000630971; ENSP00000487462; ENSG00000273397

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4700

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4700

UCSC genome browser

More...
UCSCi
uc003bcb.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047182 mRNA Translation: AAC04267.1
CR456529 mRNA Translation: CAG30415.1 Different initiation.
AK291874 mRNA Translation: BAF84563.1
AK316562 mRNA Translation: BAG38151.1
CR456714 mRNA Translation: CAG32995.1
CR541997 mRNA Translation: CAG46794.1
AL021878 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60489.1
BC002772 mRNA Translation: AAH02772.1
CCDSiCCDS33656.1
PIRiJC5821
RefSeqiNP_002481.2, NM_002490.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTBelectron microscopy3.40E16-128[»]
5XTDelectron microscopy3.70E16-128[»]
5XTHelectron microscopy3.90E16-128[»]
5XTIelectron microscopy17.40BE/E16-128[»]
SMRiP56556
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110780, 39 interactors
ComplexPortaliCPX-577, Mitochondrial respiratory chain complex I
CORUMiP56556
IntActiP56556, 63 interactors
MINTiP56556
STRINGi9606.ENSP00000418842

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157, NADH
DrugCentraliP56556

PTM databases

iPTMnetiP56556
PhosphoSitePlusiP56556

Polymorphism and mutation databases

BioMutaiNDUFA6
DMDMi298286909

Proteomic databases

EPDiP56556
jPOSTiP56556
MassIVEiP56556
PaxDbiP56556
PeptideAtlasiP56556
PRIDEiP56556
ProteomicsDBi56926
TopDownProteomicsiP56556

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
45919, 106 antibodies

The DNASU plasmid repository

More...
DNASUi
4700

Genome annotation databases

EnsembliENST00000498737; ENSP00000418842; ENSG00000184983
ENST00000605916; ENSP00000475402; ENSG00000272765
ENST00000628740; ENSP00000486781; ENSG00000277365
ENST00000630201; ENSP00000487431; ENSG00000281013
ENST00000630971; ENSP00000487462; ENSG00000273397
GeneIDi4700
KEGGihsa:4700
UCSCiuc003bcb.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4700
DisGeNETi4700
EuPathDBiHostDB:ENSG00000184983.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NDUFA6
HGNCiHGNC:7690, NDUFA6
HPAiENSG00000184983, Low tissue specificity
MalaCardsiNDUFA6
MIMi602138, gene
618253, phenotype
neXtProtiNX_P56556
OpenTargetsiENSG00000184983
Orphaneti2609, Isolated complex I deficiency
PharmGKBiPA31496

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3426, Eukaryota
GeneTreeiENSGT00390000018898
InParanoidiP56556
KOiK03950
OrthoDBi1518948at2759
PhylomeDBiP56556
TreeFamiTF105625

Enzyme and pathway databases

PathwayCommonsiP56556
ReactomeiR-HSA-611105, Respiratory electron transport
R-HSA-6799198, Complex I biogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4700, 270 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NDUFA6, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NDUFA6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4700
PharosiP56556, Tclin

Protein Ontology

More...
PROi
PR:P56556
RNActiP56556, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184983, Expressed in heart left ventricle and 247 other tissues
ExpressionAtlasiP56556, baseline and differential
GenevisibleiP56556, HS

Family and domain databases

InterProiView protein in InterPro
IPR008011, Complex1_LYR
IPR016488, NADH_Ub_cplx-1_asu_su-6
PANTHERiPTHR12964, PTHR12964, 1 hit
PfamiView protein in Pfam
PF05347, Complex1_LYR, 1 hit
PIRSFiPIRSF006643, NDUA6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDUA6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56556
Secondary accession number(s): B2RE54
, O43675, Q6FGW0, Q6IBT8, Q6IC39
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2018
Last modified: August 12, 2020
This is version 180 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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