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Entry version 203 (02 Dec 2020)
Sequence version 1 (15 Jul 1998)
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Protein

C-terminal-binding protein 2

Gene

CTBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).By similarity
Isoform 2 probably acts as a scaffold for specialized synapses.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei106NADBy similarity1
Binding sitei210NAD1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei272By similarity1
Binding sitei296NAD1 Publication1
Active sitei301By similarity1
Active sitei321Proton donorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi186 – 191NAD1 Publication6
Nucleotide bindingi243 – 249NAD1 Publication7
Nucleotide bindingi270 – 272NAD1 Publication3
Nucleotide bindingi321 – 324NAD1 Publication4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Repressor
Biological processDifferentiation, Host-virus interaction, Transcription, Transcription regulation
LigandNAD

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P56545

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-4641265, Repression of WNT target genes
R-HSA-5339700, TCF7L2 mutants don't bind CTBP

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P56545

SIGNOR Signaling Network Open Resource

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SIGNORi
P56545

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-terminal-binding protein 2
Short name:
CtBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000175029.16

Human Gene Nomenclature Database

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HGNCi
HGNC:2495, CTBP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602619, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P56545

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Nucleus, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1488

Open Targets

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OpenTargetsi
ENSG00000175029

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26996

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P56545, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3797016

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CTBP2

Domain mapping of disease mutations (DMDM)

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DMDMi
3182976

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760441 – 445C-terminal-binding protein 2Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22Asymmetric dimethylarginineCombined sources1
Modified residuei428PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P56545

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P56545

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P56545

MaxQB - The MaxQuant DataBase

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MaxQBi
P56545

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P56545

PeptideAtlas

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PeptideAtlasi
P56545

PRoteomics IDEntifications database

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PRIDEi
P56545

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
56923 [P56545-1]
56924 [P56545-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P56545

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P56545

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000175029, Expressed in thoracic mammary gland and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P56545, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P56545, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000175029, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homodimers or heterodimers of CTBP1 and CTBP2.

Interacts with HIPK2 and ZNF217.

Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity).

Interacts with PNN, NRIP1 and WIZ.

Interacts with MCRIP1 (PubMed:25728771).

By similarity5 Publications

(Microbial infection) Interacts with human adenovirus 5 E1A protein; this interaction seems to potentiate viral replication.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P56545
With#Exp.IntAct
BCL3 [P20749]2EBI-741533,EBI-958997
CCNH [P51946]5EBI-741533,EBI-741406
CTBP1 [Q13363]3EBI-741533,EBI-908846
CTBP1 - isoform 2 [Q13363-2]5EBI-741533,EBI-10171858
DMRTB1 [A0A0S2Z5I3]3EBI-741533,EBI-16431245
FHL3 [Q13643]4EBI-741533,EBI-741101
FOXP2 [O15409]3EBI-741533,EBI-983612
FUNDC1 [Q8IVP5]3EBI-741533,EBI-3059266
HIC1 [Q14526]2EBI-741533,EBI-2507362
IKZF1 [Q13422]5EBI-741533,EBI-745305
IKZF2 [Q9UKS7]3EBI-741533,EBI-3893057
LCOR [Q96JN0]5EBI-741533,EBI-746045
NOL4 - isoform 2 [O94818-2]3EBI-741533,EBI-10190763
NOL4L [Q96MY1]3EBI-741533,EBI-6660790
PLCB1 [Q9NQ66]3EBI-741533,EBI-3396023
PPP1R15A [O75807]2EBI-741533,EBI-714746
PROX1 [Q92786]2EBI-741533,EBI-3912635
RAI2 [Q9Y5P3]4EBI-741533,EBI-746228
SOX13 [Q9UN79]2EBI-741533,EBI-3928516
TGIF1 [Q15583]5EBI-741533,EBI-714215
TGIF1 - isoform 2 [Q15583-2]3EBI-741533,EBI-12691451
ZNF750 [Q32MQ0]3EBI-741533,EBI-10240029
Zbp1 [A2APF7] from Mus musculus.2EBI-741533,EBI-6115394
CTBP2 - isoform 3 [P56545-3]
With#Exp.IntAct
BAZ2B [A0A0A0MR97]5EBI-10171902,EBI-11985607
BAZ2B - isoform 2 [Q9UIF8-2]3EBI-10171902,EBI-10321972
BCAS3 [Q9H6U6]3EBI-10171902,EBI-6083685
CACNB1 [Q02641]3EBI-10171902,EBI-947514
CACNB2 [Q08289]5EBI-10171902,EBI-2874501
CACNB3 [P54284]8EBI-10171902,EBI-1184651
CACNB4 [O00305]3EBI-10171902,EBI-714838
CAPN7 [Q9Y6W3]3EBI-10171902,EBI-1765641
CATSPER1 [Q8NEC5]3EBI-10171902,EBI-744545
CCDC120 [Q96HB5]3EBI-10171902,EBI-744556
CEP68 - isoform 2 [Q76N32-2]3EBI-10171902,EBI-11975967
CSTF2 [P33240]3EBI-10171902,EBI-711360
CTBP1 - isoform 2 [Q13363-2]4EBI-10171902,EBI-10171858
itself3EBI-10171902,EBI-10171902
DMRTB1 [I6L9A0]3EBI-10171902,EBI-10178554
DTNB - isoform 5 [O60941-5]5EBI-10171902,EBI-11984733
DUSP21 [Q9H596]3EBI-10171902,EBI-7357329
EGLN3 [Q9H6Z9]3EBI-10171902,EBI-1175354
EIF4G1 - isoform 9 [Q04637-9]3EBI-10171902,EBI-12012124
ENKD1 [Q9H0I2]3EBI-10171902,EBI-744099
FLI1 [Q01543]3EBI-10171902,EBI-2271018
FOXP2 [O15409]3EBI-10171902,EBI-983612
GLIS2 [Q9BZE0]3EBI-10171902,EBI-7251368
HOXA5 [P20719]5EBI-10171902,EBI-8470697
HOXB5 [P09067]8EBI-10171902,EBI-3893317
HOXC5 [Q00444]3EBI-10171902,EBI-11955357
IKZF1 [Q13422]3EBI-10171902,EBI-745305
IKZF1 - isoform Ik7 [Q13422-7]3EBI-10171902,EBI-11522367
IKZF2 [Q9UKS7]3EBI-10171902,EBI-3893057
IKZF3 [Q9UKT9]3EBI-10171902,EBI-747204
KLF3 [P57682]3EBI-10171902,EBI-8472267
KYNU - isoform 2 [Q16719-2]3EBI-10171902,EBI-12351611
LCOR [Q96JN0]3EBI-10171902,EBI-746045
LCORL - isoform 3 [Q8N3X6-3]3EBI-10171902,EBI-12111580
LMO4 [P61968]3EBI-10171902,EBI-2798728
MSRB3 - isoform 2 [Q8IXL7-2]5EBI-10171902,EBI-10699187
NEK6 - isoform 4 [Q9HC98-4]3EBI-10171902,EBI-11750983
NOL4 - isoform 2 [O94818-2]3EBI-10171902,EBI-10190763
NOL4L [Q96MY1]3EBI-10171902,EBI-6660790
PLCB1 [Q9NQ66]3EBI-10171902,EBI-3396023
QARS1 [P47897]3EBI-10171902,EBI-347462
RAI2 [Q9Y5P3]3EBI-10171902,EBI-746228
RBBP8NL [Q8NC74]3EBI-10171902,EBI-11322432
RIMBP3 [Q9UFD9]3EBI-10171902,EBI-10182375
RNF135 [Q8IUD6]3EBI-10171902,EBI-9916363
SDCBP [O00560]3EBI-10171902,EBI-727004
SHISA6 [Q6ZSJ9]3EBI-10171902,EBI-12037847
SOX13 [Q9UN79]3EBI-10171902,EBI-3928516
TLE5 - isoform 2 [Q08117-2]3EBI-10171902,EBI-11741437
TRIML2 [Q8N7C3]3EBI-10171902,EBI-11059915
TSHZ3 [Q63HK5]6EBI-10171902,EBI-9053916
VRTN [Q9H8Y1]5EBI-10171902,EBI-12894399
ZBTB18 [Q99592]6EBI-10171902,EBI-3232046
ZBTB42 [B2RXF5]3EBI-10171902,EBI-12287587
ZSCAN4 [Q8NAM6]3EBI-10171902,EBI-7252920

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
107870, 293 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P56545

Database of interacting proteins

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DIPi
DIP-42104N

Protein interaction database and analysis system

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IntActi
P56545, 120 interactors

Molecular INTeraction database

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MINTi
P56545

STRING: functional protein association networks

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STRINGi
9606.ENSP00000311825

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P56545

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P56545, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P56545

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P56545

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0067, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000154430

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_019796_1_3_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P56545

Identification of Orthologs from Complete Genome Data

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OMAi
EYTIKQM

Database of Orthologous Groups

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OrthoDBi
700058at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P56545

TreeFam database of animal gene trees

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TreeFami
TF313593

Family and domain databases

Conserved Domains Database

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CDDi
cd05299, CtBP_dh, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR043322, CtBP
IPR006139, D-isomer_2_OHA_DH_cat_dom
IPR029753, D-isomer_DH_CS
IPR006140, D-isomer_DH_NAD-bd
IPR036291, NAD(P)-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00389, 2-Hacid_dh, 1 hit
PF02826, 2-Hacid_dh_C, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51735, SSF51735, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00671, D_2_HYDROXYACID_DH_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P56545-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI
60 70 80 90 100
LKDLATVAFC DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV
110 120 130 140 150
IVRIGSGYDN VDIKAAGELG IAVCNIPSAA VEETADSTIC HILNLYRRNT
160 170 180 190 200
WLYQALREGT RVQSVEQIRE VASGAARIRG ETLGLIGFGR TGQAVAVRAK
210 220 230 240 250
AFGFSVIFYD PYLQDGIERS LGVQRVYTLQ DLLYQSDCVS LHCNLNEHNH
260 270 280 290 300
HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES
310 320 330 340 350
EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP
360 370 380 390 400
ESLRNCVNKE FFVTSAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP
410 420 430 440
AAMEGIIPGG IPVTHNLPTV AHPSQAPSPN QPTKHGDNRE HPNEQ
Length:445
Mass (Da):48,945
Last modified:July 15, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A8C21CEB36807FA
GO
Isoform 2 (identifier: P56545-2) [UniParc]FASTAAdd to basket
Also known as: Ribeye

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MALVDKHKVKRQRLDRICEG → MPVPSRHINI...VSTMLAPEPS

Show »
Length:985
Mass (Da):106,187
Checksum:i90EC841907295622
GO
Isoform 3 (identifier: P56545-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MALVDKHKVKRQRLDRICE → MRPGLPGPTG...LPVHSYRSWA

Show »
Length:513
Mass (Da):56,102
Checksum:iA7A54EB7F0F34922
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYL1A0A087WYL1_HUMAN
C-terminal-binding protein 2
CTBP2
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti87L → F in AAG45951 (PubMed:11163272).Curated1
Sequence conflicti88T → N in AAG45951 (PubMed:11163272).Curated1
Sequence conflicti112D → N in AAG45951 (PubMed:11163272).Curated1
Sequence conflicti292G → R in AAH37900 (PubMed:15489334).Curated1
Sequence conflicti411I → T in AAH47018 (PubMed:15489334).Curated1
Isoform 2 (identifier: P56545-2)
Sequence conflicti455Y → H in AAG45951 (PubMed:11163272).Curated1
Sequence conflicti539Q → E in AAG45951 (PubMed:11163272).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0276151 – 20MALVD…RICEG → MPVPSRHINIGRSQSWDAAG WYEGPWENAESLRPLGRRSS LTYGTAEGTWFEPNHRPQDA ALPVAAEPYLYREAVYNSVA ARKGSTPDFTFYDSRQAVMS GRSPLLPREYYSDPSGAARV PKEPPLYRDPGVSRPVPSYG VLGSRTSWDPMQGRSPALQD AGHLYRDPGGKMIPQGRQTQ SRAASPGRYGREQPDTRYGA EVPAYPLSQVFSDISERPID PAPARQVAPTCLVVDPSSAA APEGSTGVAPGALNRGYGPA RESIPSKMAYETYEADLSTF QGPGGKRTVLPEFLAFLRAE GLAEATLGALLQQGFDSPAV LATLEDADIKSVAPNLGQAR VLSRLANSCRTEMQLRRQDR GGPLPRARSSSFSHRSELLH GDLASLGAAAPLQTASPRAG DPARRPSSAPSQHLLETAAT YSAPGVGTHAPHFPSNSGYS SPTPCALTARLSPTYPLQAG VALTNPGPSNPLHPGPRTAY STAYTVPMELLKRERNVAAS PLPSPHGSPQVLRKPGAPLG PSTLPPASQSLHTPHSPYQK VARRTGAPIIVSTMLAPEPS in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0589461 – 19MALVD…DRICE → MRPGLPGPTGLCAQTSSRGQ KSVLKQKESCGIWQLYHFLS RKQEPRWEPCVSGSSSGDGA VADLADELRGYPALCCTLPV HSYRSWA in isoform 3. Add BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF016507 mRNA Translation: AAC39603.1
AF222711 mRNA Translation: AAG45951.1
BT007012 mRNA Translation: AAP35658.1
AK290390 mRNA Translation: BAF83079.1
AL833398 mRNA Translation: CAH10590.1
AL596261 Genomic DNA No translation available.
AL731571 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49247.1
CH471066 Genomic DNA Translation: EAW49250.1
CH471066 Genomic DNA Translation: EAW49249.1
BC002486 mRNA Translation: AAH02486.1
BC037900 mRNA Translation: AAH37900.1
BC047018 mRNA Translation: AAH47018.1
BC052276 mRNA Translation: AAH52276.1
BC072020 mRNA Translation: AAH72020.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7643.1 [P56545-1]
CCDS7644.1 [P56545-2]
CCDS86154.1 [P56545-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001077383.1, NM_001083914.2 [P56545-1]
NP_001277143.1, NM_001290214.2 [P56545-1]
NP_001277144.1, NM_001290215.2 [P56545-1]
NP_001307941.1, NM_001321012.1 [P56545-1]
NP_001307942.1, NM_001321013.1 [P56545-1]
NP_001307943.1, NM_001321014.1 [P56545-1]
NP_001320.1, NM_001329.3 [P56545-1]
NP_073713.2, NM_022802.2 [P56545-2]
XP_005269618.1, XM_005269561.2 [P56545-1]
XP_005269621.1, XM_005269564.2 [P56545-1]
XP_005269624.1, XM_005269567.2 [P56545-1]
XP_005269625.1, XM_005269568.4 [P56545-1]
XP_005269626.1, XM_005269569.2 [P56545-1]
XP_005269628.1, XM_005269571.2 [P56545-1]
XP_005269629.1, XM_005269572.3 [P56545-1]
XP_006717705.1, XM_006717642.2 [P56545-1]
XP_011537651.1, XM_011539349.2
XP_011537653.1, XM_011539351.1 [P56545-1]
XP_011537655.1, XM_011539353.1 [P56545-1]
XP_011537656.1, XM_011539354.1 [P56545-1]
XP_011537657.1, XM_011539355.1 [P56545-1]
XP_016871245.1, XM_017015756.1 [P56545-1]
XP_016871246.1, XM_017015757.1 [P56545-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309035; ENSP00000311825; ENSG00000175029 [P56545-2]
ENST00000334808; ENSP00000357816; ENSG00000175029 [P56545-3]
ENST00000337195; ENSP00000338615; ENSG00000175029 [P56545-1]
ENST00000411419; ENSP00000410474; ENSG00000175029 [P56545-1]
ENST00000494626; ENSP00000436285; ENSG00000175029 [P56545-1]
ENST00000531469; ENSP00000434630; ENSG00000175029 [P56545-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1488

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1488

UCSC genome browser

More...
UCSCi
uc001lie.5, human [P56545-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016507 mRNA Translation: AAC39603.1
AF222711 mRNA Translation: AAG45951.1
BT007012 mRNA Translation: AAP35658.1
AK290390 mRNA Translation: BAF83079.1
AL833398 mRNA Translation: CAH10590.1
AL596261 Genomic DNA No translation available.
AL731571 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49247.1
CH471066 Genomic DNA Translation: EAW49250.1
CH471066 Genomic DNA Translation: EAW49249.1
BC002486 mRNA Translation: AAH02486.1
BC037900 mRNA Translation: AAH37900.1
BC047018 mRNA Translation: AAH47018.1
BC052276 mRNA Translation: AAH52276.1
BC072020 mRNA Translation: AAH72020.1
CCDSiCCDS7643.1 [P56545-1]
CCDS7644.1 [P56545-2]
CCDS86154.1 [P56545-3]
RefSeqiNP_001077383.1, NM_001083914.2 [P56545-1]
NP_001277143.1, NM_001290214.2 [P56545-1]
NP_001277144.1, NM_001290215.2 [P56545-1]
NP_001307941.1, NM_001321012.1 [P56545-1]
NP_001307942.1, NM_001321013.1 [P56545-1]
NP_001307943.1, NM_001321014.1 [P56545-1]
NP_001320.1, NM_001329.3 [P56545-1]
NP_073713.2, NM_022802.2 [P56545-2]
XP_005269618.1, XM_005269561.2 [P56545-1]
XP_005269621.1, XM_005269564.2 [P56545-1]
XP_005269624.1, XM_005269567.2 [P56545-1]
XP_005269625.1, XM_005269568.4 [P56545-1]
XP_005269626.1, XM_005269569.2 [P56545-1]
XP_005269628.1, XM_005269571.2 [P56545-1]
XP_005269629.1, XM_005269572.3 [P56545-1]
XP_006717705.1, XM_006717642.2 [P56545-1]
XP_011537651.1, XM_011539349.2
XP_011537653.1, XM_011539351.1 [P56545-1]
XP_011537655.1, XM_011539353.1 [P56545-1]
XP_011537656.1, XM_011539354.1 [P56545-1]
XP_011537657.1, XM_011539355.1 [P56545-1]
XP_016871245.1, XM_017015756.1 [P56545-1]
XP_016871246.1, XM_017015757.1 [P56545-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OMEX-ray2.80A/B/C/D/E/F/G/H31-364[»]
4LCJX-ray2.86A/B/C/D/E/F/G/H31-362[»]
SMRiP56545
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107870, 293 interactors
CORUMiP56545
DIPiDIP-42104N
IntActiP56545, 120 interactors
MINTiP56545
STRINGi9606.ENSP00000311825

Chemistry databases

BindingDBiP56545
ChEMBLiCHEMBL3797016

PTM databases

iPTMnetiP56545
PhosphoSitePlusiP56545

Polymorphism and mutation databases

BioMutaiCTBP2
DMDMi3182976

Proteomic databases

EPDiP56545
jPOSTiP56545
MassIVEiP56545
MaxQBiP56545
PaxDbiP56545
PeptideAtlasiP56545
PRIDEiP56545
ProteomicsDBi56923 [P56545-1]
56924 [P56545-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
19137, 361 antibodies

The DNASU plasmid repository

More...
DNASUi
1488

Genome annotation databases

EnsembliENST00000309035; ENSP00000311825; ENSG00000175029 [P56545-2]
ENST00000334808; ENSP00000357816; ENSG00000175029 [P56545-3]
ENST00000337195; ENSP00000338615; ENSG00000175029 [P56545-1]
ENST00000411419; ENSP00000410474; ENSG00000175029 [P56545-1]
ENST00000494626; ENSP00000436285; ENSG00000175029 [P56545-1]
ENST00000531469; ENSP00000434630; ENSG00000175029 [P56545-1]
GeneIDi1488
KEGGihsa:1488
UCSCiuc001lie.5, human [P56545-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1488
DisGeNETi1488
EuPathDBiHostDB:ENSG00000175029.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CTBP2
HGNCiHGNC:2495, CTBP2
HPAiENSG00000175029, Low tissue specificity
MIMi602619, gene
neXtProtiNX_P56545
OpenTargetsiENSG00000175029
PharmGKBiPA26996

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0067, Eukaryota
GeneTreeiENSGT00940000154430
HOGENOMiCLU_019796_1_3_1
InParanoidiP56545
OMAiEYTIKQM
OrthoDBi700058at2759
PhylomeDBiP56545
TreeFamiTF313593

Enzyme and pathway databases

PathwayCommonsiP56545
ReactomeiR-HSA-4641265, Repression of WNT target genes
R-HSA-5339700, TCF7L2 mutants don't bind CTBP
SignaLinkiP56545
SIGNORiP56545

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1488, 119 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CTBP2, human
EvolutionaryTraceiP56545

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CTBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1488
PharosiP56545, Tchem

Protein Ontology

More...
PROi
PR:P56545
RNActiP56545, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000175029, Expressed in thoracic mammary gland and 249 other tissues
ExpressionAtlasiP56545, baseline and differential
GenevisibleiP56545, HS

Family and domain databases

CDDicd05299, CtBP_dh, 1 hit
InterProiView protein in InterPro
IPR043322, CtBP
IPR006139, D-isomer_2_OHA_DH_cat_dom
IPR029753, D-isomer_DH_CS
IPR006140, D-isomer_DH_NAD-bd
IPR036291, NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389, 2-Hacid_dh, 1 hit
PF02826, 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735, SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00671, D_2_HYDROXYACID_DH_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTBP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56545
Secondary accession number(s): A8K2X5
, D3DRF5, O43449, Q5SQP7, Q69YI3, Q86SV0, Q8IY44, Q9H2T8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: December 2, 2020
This is version 203 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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