Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eukaryotic translation initiation factor 6

Gene

EIF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity).UniRule annotation4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ribosomal large subunit binding Source: GO_Central
  • ribosome binding Source: UniProtKB
  • translation initiation factor activity Source: UniProtKB-UniRule

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis, Ribosome biogenesis

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P56537

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Alternative name(s):
B(2)GCN homolog
B4 integrin interactor
CAB
p27(BBP)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF6UniRule annotationImported
Synonyms:EIF3A, ITGB4BPUniRule annotation
ORF Names:OK/SW-cl.27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000242372.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6159 EIF6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602912 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P56537

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3692

Open Targets

More...
OpenTargetsi
ENSG00000242372

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29958

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
8361 Hom s eIF6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001537341 – 245Eukaryotic translation initiation factor 6Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei113PhosphotyrosineCombined sources1
Modified residuei165PhosphothreonineUniRule annotationBy similarity1
Modified residuei166PhosphoserineUniRule annotationBy similarity1
Modified residuei174Phosphoserine; by CK1UniRule annotation2 Publications1
Modified residuei175Phosphoserine; by CK1UniRule annotation2 Publications1
Modified residuei235Phosphoserine; by PKCUniRule annotation1 Publication1
Modified residuei239PhosphoserineCombined sources1
Modified residuei243PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P56537

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P56537

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56537

PeptideAtlas

More...
PeptideAtlasi
P56537

PRoteomics IDEntifications database

More...
PRIDEi
P56537

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56921

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P56537-1 [P56537-1]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P56537

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00010105

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P56537

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P56537

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P56537

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P56537

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000242372 Expressed in 111 organ(s), highest expression level in esophagus mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_EIF3A
HS_EIF6

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P56537 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P56537 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040873

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).UniRule annotation2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109898, 155 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P56537

Protein interaction database and analysis system

More...
IntActi
P56537, 31 interactors

Molecular INTeraction database

More...
MINTi
P56537

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363559

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P56537

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P56537

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3185 Eukaryota
COG1976 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015972

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230605

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001300

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P56537

KEGG Orthology (KO)

More...
KOi
K03264

Identification of Orthologs from Complete Genome Data

More...
OMAi
NDWCAFT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0HYF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P56537

TreeFam database of animal gene trees

More...
TreeFami
TF105396

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00527 IF6, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00032 eIF_6, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002769 eIF6

The PANTHER Classification System

More...
PANTHERi
PTHR10784 PTHR10784, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01912 eIF-6, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006413 IF-6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00654 eIF6, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00323 eIF-6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P56537-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH
60 70 80 90 100
ASIAGCRIIG RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD TVQIRRVEER
110 120 130 140 150
LSALGNVTTC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TVADQVLVGS
160 170 180 190 200
YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP LVAGTVNRGS EVIAAGMVVN
210 220 230 240
DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL IDSLT
Length:245
Mass (Da):26,599
Last modified:July 15, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BA97CD5DB0C17C3
GO
Isoform 2 (identifier: P56537-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-123: SVFEGELSDT...VALVHPDLDR → RCGGSPGAYG...AAASSGACVW

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:226
Mass (Da):23,735
Checksum:iA14404615A3FE42B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZBH1B7ZBH1_HUMAN
Eukaryotic translation initiation f...
EIF6
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J1Y7A0A0B4J1Y7_HUMAN
Eukaryotic translation initiation f...
EIF6
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDS6F8WDS6_HUMAN
Eukaryotic translation initiation f...
EIF6
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD20F8WD20_HUMAN
Eukaryotic translation initiation f...
EIF6
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35 – 36Missing in AAK39426 (PubMed:11290417).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04674736 – 123SVFEG…PDLDR → RCGGSPGAYGGGEACAGVKS SGSGRVPAPLPRHHRVHVPT VCSRASSPIPSPWCTRLSPA AASSGACVW in isoform 2. CuratedAdd BLAST88

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF022229 mRNA Translation: AAB97735.1
Y11435 mRNA Translation: CAA72243.1
AF289541, AF289540 Genomic DNA Translation: AAK39426.1
AF047433 mRNA Translation: AAC39897.1
AK314969 mRNA Translation: BAG37470.1
AB062289 mRNA Translation: BAB93472.1
CR456764 mRNA Translation: CAG33045.1
AL121753 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76221.1
BC001119 mRNA Translation: AAH01119.1
BC011845 mRNA Translation: AAH11845.1
BC019305 mRNA Translation: AAH19305.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13249.1 [P56537-1]
CCDS13250.1 [P56537-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001254739.1, NM_001267810.1 [P56537-1]
NP_002203.1, NM_002212.3 [P56537-1]
NP_852131.1, NM_181466.2 [P56537-2]
NP_852133.1, NM_181468.2 [P56537-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.743992

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374436; ENSP00000363559; ENSG00000242372 [P56537-1]
ENST00000374443; ENSP00000363566; ENSG00000242372 [P56537-2]
ENST00000374450; ENSP00000363574; ENSG00000242372 [P56537-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3692

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3692

UCSC genome browser

More...
UCSCi
uc002xbv.3 human [P56537-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022229 mRNA Translation: AAB97735.1
Y11435 mRNA Translation: CAA72243.1
AF289541, AF289540 Genomic DNA Translation: AAK39426.1
AF047433 mRNA Translation: AAC39897.1
AK314969 mRNA Translation: BAG37470.1
AB062289 mRNA Translation: BAB93472.1
CR456764 mRNA Translation: CAG33045.1
AL121753 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76221.1
BC001119 mRNA Translation: AAH01119.1
BC011845 mRNA Translation: AAH11845.1
BC019305 mRNA Translation: AAH19305.1
CCDSiCCDS13249.1 [P56537-1]
CCDS13250.1 [P56537-2]
RefSeqiNP_001254739.1, NM_001267810.1 [P56537-1]
NP_002203.1, NM_002212.3 [P56537-1]
NP_852131.1, NM_181466.2 [P56537-2]
NP_852133.1, NM_181468.2 [P56537-1]
UniGeneiHs.743992

3D structure databases

ProteinModelPortaliP56537
SMRiP56537
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109898, 155 interactors
CORUMiP56537
IntActiP56537, 31 interactors
MINTiP56537
STRINGi9606.ENSP00000363559

Protein family/group databases

Allergomei8361 Hom s eIF6

PTM databases

iPTMnetiP56537
PhosphoSitePlusiP56537
SwissPalmiP56537

Polymorphism and mutation databases

BioMutaiEIF6

2D gel databases

OGPiP56537
REPRODUCTION-2DPAGEiIPI00010105
SWISS-2DPAGEiP56537

Proteomic databases

EPDiP56537
MaxQBiP56537
PaxDbiP56537
PeptideAtlasiP56537
PRIDEiP56537
ProteomicsDBi56921
TopDownProteomicsiP56537-1 [P56537-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3692
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374436; ENSP00000363559; ENSG00000242372 [P56537-1]
ENST00000374443; ENSP00000363566; ENSG00000242372 [P56537-2]
ENST00000374450; ENSP00000363574; ENSG00000242372 [P56537-1]
GeneIDi3692
KEGGihsa:3692
UCSCiuc002xbv.3 human [P56537-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3692
DisGeNETi3692
EuPathDBiHostDB:ENSG00000242372.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EIF6
HGNCiHGNC:6159 EIF6
HPAiHPA040873
MIMi602912 gene
neXtProtiNX_P56537
OpenTargetsiENSG00000242372
PharmGKBiPA29958

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3185 Eukaryota
COG1976 LUCA
GeneTreeiENSGT00390000015972
HOGENOMiHOG000230605
HOVERGENiHBG001300
InParanoidiP56537
KOiK03264
OMAiNDWCAFT
OrthoDBiEOG091G0HYF
PhylomeDBiP56537
TreeFamiTF105396

Enzyme and pathway databases

SIGNORiP56537

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EIF6 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
EIF6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3692

Protein Ontology

More...
PROi
PR:P56537

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000242372 Expressed in 111 organ(s), highest expression level in esophagus mucosa
CleanExiHS_EIF3A
HS_EIF6
ExpressionAtlasiP56537 baseline and differential
GenevisibleiP56537 HS

Family and domain databases

CDDicd00527 IF6, 1 hit
HAMAPiMF_00032 eIF_6, 1 hit
InterProiView protein in InterPro
IPR002769 eIF6
PANTHERiPTHR10784 PTHR10784, 1 hit
PfamiView protein in Pfam
PF01912 eIF-6, 1 hit
PIRSFiPIRSF006413 IF-6, 1 hit
SMARTiView protein in SMART
SM00654 eIF6, 1 hit
TIGRFAMsiTIGR00323 eIF-6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56537
Secondary accession number(s): B7ZBG9, Q6IBN8, Q96TD5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Translation initiation factors
    List of translation initiation factor entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again