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Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene

Cd38

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity (By similarity).By similarity1 Publication

Catalytic activityi

NAD+ + H2O = ADP-D-ribose + nicotinamide.
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei123By similarity1
Active sitei205By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transferase
LigandNAD, NADP

Enzyme and pathway databases

BRENDAi2.4.99.20 3474
ReactomeiR-MMU-196807 Nicotinate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC:3.2.2.6)
Alternative name(s):
2'-phospho-ADP-ribosyl cyclase
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)
2'-phospho-cyclic-ADP-ribose transferase
ADP-ribosyl cyclase 1
Short name:
ADPRC 1
Cyclic ADP-ribose hydrolase 1
Short name:
cADPr hydrolase 1
I-19
NIM-R5 antigen
CD_antigen: CD38
Gene namesi
Name:Cd38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107474 Cd38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 44Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini45 – 304ExtracellularSequence analysisAdd BLAST260

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3425388

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440681 – 304ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 861 Publication
Disulfide bondi103 ↔ 1841 Publication
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 1771 Publication
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi258 ↔ 2791 Publication
Disulfide bondi291 ↔ 3001 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP56528
PeptideAtlasiP56528
PRIDEiP56528

PTM databases

iPTMnetiP56528
PhosphoSitePlusiP56528
SwissPalmiP56528

Expressioni

Gene expression databases

BgeeiENSMUSG00000029084 Expressed in 252 organ(s), highest expression level in stroma of bone marrow
CleanExiMM_CD38
ExpressionAtlasiP56528 baseline and differential
GenevisibleiP56528 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-8401721,EBI-8401721

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198590, 1 interactor
DIPiDIP-59864N
IntActiP56528, 1 interactor
MINTiP56528
STRINGi10090.ENSMUSP00000030964

Chemistry databases

BindingDBiP56528

Structurei

Secondary structure

1304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP56528
SMRiP56528
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56528

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosyl cyclase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH8E Eukaryota
ENOG4111W33 LUCA
GeneTreeiENSGT00390000017291
HOGENOMiHOG000293141
HOVERGENiHBG005277
InParanoidiP56528
KOiK01242
OMAiCVKNPEH
OrthoDBiEOG091G0GI3
PhylomeDBiP56528
TreeFamiTF332530

Family and domain databases

CDDicd04759 Rib_hydrolase, 1 hit
InterProiView protein in InterPro
IPR003193 ADP-ribosyl_cyclase
IPR033567 CD38
PANTHERiPTHR10912 PTHR10912, 1 hit
PTHR10912:SF5 PTHR10912:SF5, 1 hit
PfamiView protein in Pfam
PF02267 Rib_hydrolayse, 1 hit

Sequencei

Sequence statusi: Complete.

P56528-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANYEFSQVS GDRPGCRLSR KAQIGLGVGL LVLIALVVGI VVILLRPRSL
60 70 80 90 100
LVWTGEPTTK HFSDIFLGRC LIYTQILRPE MRDQNCQEIL STFKGAFVSK
110 120 130 140 150
NPCNITREDY APLVKLVTQT IPCNKTLFWS KSKHLAHQYT WIQGKMFTLE
160 170 180 190 200
DTLLGYIADD LRWCGDPSTS DMNYVSCPHW SENCPNNPIT VFWKVISQKF
210 220 230 240 250
AEDACGVVQV MLNGSLREPF YKNSTFGSVE VFSLDPNKVH KLQAWVMHDI
260 270 280 290 300
EGASSNACSS SSLNELKMIV QKRNMIFACV DNYRPARFLQ CVKNPEHPSC

RLNT
Length:304
Mass (Da):34,408
Last modified:November 23, 2004 - v2
Checksum:iDD0A7747C5F67D6F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191V → M in AAA03163 (PubMed:8376770).Curated1
Sequence conflicti229V → L in AAA03163 (PubMed:8376770).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11332 mRNA Translation: AAA03163.1
AK038439 mRNA Translation: BAC30000.1
AK040498 mRNA Translation: BAC30607.1
AK042970 mRNA Translation: BAC31423.1
BC046312 mRNA Translation: AAH46312.1
CCDSiCCDS19265.1
PIRiI49586
RefSeqiNP_031672.2, NM_007646.5
UniGeneiMm.249873

Genome annotation databases

EnsembliENSMUST00000030964; ENSMUSP00000030964; ENSMUSG00000029084
GeneIDi12494
KEGGimmu:12494
UCSCiuc008xic.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11332 mRNA Translation: AAA03163.1
AK038439 mRNA Translation: BAC30000.1
AK040498 mRNA Translation: BAC30607.1
AK042970 mRNA Translation: BAC31423.1
BC046312 mRNA Translation: AAH46312.1
CCDSiCCDS19265.1
PIRiI49586
RefSeqiNP_031672.2, NM_007646.5
UniGeneiMm.249873

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EG9X-ray2.80A/B48-288[»]
ProteinModelPortaliP56528
SMRiP56528
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198590, 1 interactor
DIPiDIP-59864N
IntActiP56528, 1 interactor
MINTiP56528
STRINGi10090.ENSMUSP00000030964

Chemistry databases

BindingDBiP56528
ChEMBLiCHEMBL3425388

PTM databases

iPTMnetiP56528
PhosphoSitePlusiP56528
SwissPalmiP56528

Proteomic databases

PaxDbiP56528
PeptideAtlasiP56528
PRIDEiP56528

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030964; ENSMUSP00000030964; ENSMUSG00000029084
GeneIDi12494
KEGGimmu:12494
UCSCiuc008xic.2 mouse

Organism-specific databases

CTDi952
MGIiMGI:107474 Cd38

Phylogenomic databases

eggNOGiENOG410IH8E Eukaryota
ENOG4111W33 LUCA
GeneTreeiENSGT00390000017291
HOGENOMiHOG000293141
HOVERGENiHBG005277
InParanoidiP56528
KOiK01242
OMAiCVKNPEH
OrthoDBiEOG091G0GI3
PhylomeDBiP56528
TreeFamiTF332530

Enzyme and pathway databases

BRENDAi2.4.99.20 3474
ReactomeiR-MMU-196807 Nicotinate metabolism

Miscellaneous databases

ChiTaRSiCd38 mouse
EvolutionaryTraceiP56528
PROiPR:P56528
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029084 Expressed in 252 organ(s), highest expression level in stroma of bone marrow
CleanExiMM_CD38
ExpressionAtlasiP56528 baseline and differential
GenevisibleiP56528 MM

Family and domain databases

CDDicd04759 Rib_hydrolase, 1 hit
InterProiView protein in InterPro
IPR003193 ADP-ribosyl_cyclase
IPR033567 CD38
PANTHERiPTHR10912 PTHR10912, 1 hit
PTHR10912:SF5 PTHR10912:SF5, 1 hit
PfamiView protein in Pfam
PF02267 Rib_hydrolayse, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD38_MOUSE
AccessioniPrimary (citable) accession number: P56528
Secondary accession number(s): Q8BFY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 23, 2004
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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