UniProtKB - P56519 (HDAC2_CHICK)
Protein
Histone deacetylase 2
Gene
HDAC2
Organism
Gallus gallus (Chicken)
Status
Functioni
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity
Catalytic activityi
- EC:3.5.1.98
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 142 | By similarity | 1 |
GO - Molecular functioni
- histone deacetylase activity Source: GO_Central
- NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
- transcription factor binding Source: UniProtKB
GO - Biological processi
- chromatin organization Source: UniProtKB
- histone H3 deacetylation Source: GO_Central
- histone H4 deacetylation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Chromatin regulator, Hydrolase, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HDAC2 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- ESC/E(Z) complex Source: UniProtKB
- histone deacetylase complex Source: GO_Central
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114695 | 1 – 488 | Histone deacetylase 2Add BLAST | 488 |
Proteomic databases
PaxDbi | P56519 |
Interactioni
GO - Molecular functioni
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 675914, 3 interactors |
IntActi | P56519, 1 interactor |
STRINGi | 9031.ENSGALP00000024133 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 9 – 322 | Histone deacetylaseAdd BLAST | 314 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 300 – 303 | Poly-Gly | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1342, Eukaryota |
InParanoidi | P56519 |
PhylomeDBi | P56519 |
Family and domain databases
Gene3Di | 3.40.800.20, 1 hit |
InterProi | View protein in InterPro IPR000286, His_deacetylse IPR003084, His_deacetylse_1 IPR023801, His_deacetylse_dom IPR037138, His_deacetylse_dom_sf IPR023696, Ureohydrolase_dom_sf |
Pfami | View protein in Pfam PF00850, Hist_deacetyl, 1 hit |
PIRSFi | PIRSF037913, His_deacetylse_1, 1 hit |
PRINTSi | PR01270, HDASUPER PR01271, HISDACETLASE |
SUPFAMi | SSF52768, SSF52768, 1 hit |
i Sequence
Sequence statusi: Complete.
P56519-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR
60 70 80 90 100
KMEIYRPHKA TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED
110 120 130 140 150
CPVFDGLFEF CQLSTGGSVA GAVKLNRQQT DMAVNWAGGL HHAKKSEASG
160 170 180 190 200
FCYVNDIVLA ILELLKYHQR VLYIDIDIHH GDGVEEAFYT TDRVMTVSEV
210 220 230 240 250
SMVNNFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ IFKPIISKVM
260 270 280 290 300
EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG
310 320 330 340 350
GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN
360 370 380 390 400
MTNQNTPEYM EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE
410 420 430 440 450
DPDKRISIRA SDKRIACDEE FSDSEDEGEG GRRNVADHKK GAKKARIEED
460 470 480
KKETEDKKAD VKEEDKSKDN SGEKTDTKGA KSEQLSNP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF039752 mRNA Translation: AAB96924.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF039752 mRNA Translation: AAB96924.1 |
3D structure databases
SMRi | P56519 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 675914, 3 interactors |
IntActi | P56519, 1 interactor |
STRINGi | 9031.ENSGALP00000024133 |
Proteomic databases
PaxDbi | P56519 |
Phylogenomic databases
eggNOGi | KOG1342, Eukaryota |
InParanoidi | P56519 |
PhylomeDBi | P56519 |
Family and domain databases
Gene3Di | 3.40.800.20, 1 hit |
InterProi | View protein in InterPro IPR000286, His_deacetylse IPR003084, His_deacetylse_1 IPR023801, His_deacetylse_dom IPR037138, His_deacetylse_dom_sf IPR023696, Ureohydrolase_dom_sf |
Pfami | View protein in Pfam PF00850, Hist_deacetyl, 1 hit |
PIRSFi | PIRSF037913, His_deacetylse_1, 1 hit |
PRINTSi | PR01270, HDASUPER PR01271, HISDACETLASE |
SUPFAMi | SSF52768, SSF52768, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HDAC2_CHICK | |
Accessioni | P56519Primary (citable) accession number: P56519 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | October 7, 2020 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families