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UniProtKB - P56501 (UCP3_MOUSE)
Protein
Mitochondrial uncoupling protein 3
Gene
Ucp3
Organism
Mus musculus (Mouse)
Status
Functioni
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity).
By similarityGO - Molecular functioni
- oxidative phosphorylation uncoupler activity Source: MGI
GO - Biological processi
- adaptive thermogenesis Source: GO_Central
- aging Source: Ensembl
- cellular response to hormone stimulus Source: Ensembl
- fatty acid metabolic process Source: MGI
- mitochondrial transmembrane transport Source: GO_Central
- mitochondrial transport Source: InterPro
- response to activity Source: Ensembl
- response to cold Source: GO_Central
- response to glucocorticoid Source: Ensembl
- response to hypoxia Source: MGI
- response to insulin Source: Ensembl
- response to nutrient Source: Ensembl
- response to superoxide Source: MGI
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-MMU-167826, The fatty acid cycling model R-MMU-167827, The proton buffering model |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial uncoupling protein 3Short name: UCP 3 Alternative name(s): Solute carrier family 25 member 9 |
Gene namesi | Name:Ucp3 Synonyms:Slc25a9 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1099787, Ucp3 |
VEuPathDBi | HostDB:ENSMUSG00000032942 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 11 – 32 | Helical; Name=1Sequence analysisAdd BLAST | 22 | |
Transmembranei | 74 – 96 | Helical; Name=2Sequence analysisAdd BLAST | 23 | |
Transmembranei | 117 – 133 | Helical; Name=3Sequence analysisAdd BLAST | 17 | |
Transmembranei | 180 – 196 | Helical; Name=4Sequence analysisAdd BLAST | 17 | |
Transmembranei | 214 – 233 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Transmembranei | 268 – 290 | Helical; Name=6Sequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090673 | 1 – 308 | Mitochondrial uncoupling protein 3Add BLAST | 308 |
Proteomic databases
MaxQBi | P56501 |
PaxDbi | P56501 |
PRIDEi | P56501 |
ProteomicsDBi | 298428 |
PTM databases
iPTMneti | P56501 |
PhosphoSitePlusi | P56501 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032942, Expressed in hindlimb stylopod muscle and 134 other tissues |
Genevisiblei | P56501, MM |
Interactioni
Protein-protein interaction databases
CORUMi | P56501 |
STRINGi | 10090.ENSMUSP00000032958 |
Miscellaneous databases
RNActi | P56501, protein |
Structurei
3D structure databases
AlphaFoldDBi | P56501 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 11 – 102 | Solcar 1Add BLAST | 92 | |
Repeati | 111 – 202 | Solcar 2Add BLAST | 92 | |
Repeati | 211 – 296 | Solcar 3Add BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 275 – 297 | Purine nucleotide bindingBy similarityAdd BLAST | 23 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0753, Eukaryota |
GeneTreei | ENSGT00940000161030 |
HOGENOMi | CLU_015166_14_2_1 |
InParanoidi | P56501 |
OMAi | DCMLKLV |
OrthoDBi | 984118at2759 |
PhylomeDBi | P56501 |
TreeFami | TF323211 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002030, Mit_uncoupling_UCP-like IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00784, MTUNCOUPLING |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
P56501-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVGLQPSEVP PTTVVKFLGA GTAACFADLL TFPLDTAKVR LQIQGENPGA
60 70 80 90 100
QSVQYRGVLG TILTMVRTEG PRSPYSGLVA GLHRQMSFAS IRIGLYDSVK
110 120 130 140 150
QFYTPKGADH SSVAIRILAG CTTGAMAVTC AQPTDVVKVR FQAMIRLGTG
160 170 180 190 200
GERKYRGTMD AYRTIAREEG VRGLWKGTWP NITRNAIVNC AEMVTYDIIK
210 220 230 240 250
EKLLESHLFT DNFPCHFVSA FGAGFCATVV ASPVDVVKTR YMNAPLGRYR
260 270 280 290 300
SPLHCMLKMV AQEGPTAFYK GFVPSFLRLG AWNVMMFVTY EQLKRALMKV
QVLRESPF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 179 | W → L in BAA31989 (PubMed:9600108).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF032902 mRNA Translation: AAB87084.1 AB010742 mRNA Translation: BAA25697.1 AF030164 mRNA Translation: AAD01892.1 AB008216 mRNA Translation: BAA33502.1 AF053352 mRNA Translation: AAC28328.1 AB013132 mRNA Translation: BAA31989.1 AF019883 mRNA Translation: AAB71543.1 |
CCDSi | CCDS21497.1 |
RefSeqi | NP_033490.1, NM_009464.3 |
Genome annotation databases
Ensembli | ENSMUST00000032958; ENSMUSP00000032958; ENSMUSG00000032942 ENSMUST00000107059; ENSMUSP00000102674; ENSMUSG00000032942 |
GeneIDi | 22229 |
KEGGi | mmu:22229 |
UCSCi | uc009ina.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF032902 mRNA Translation: AAB87084.1 AB010742 mRNA Translation: BAA25697.1 AF030164 mRNA Translation: AAD01892.1 AB008216 mRNA Translation: BAA33502.1 AF053352 mRNA Translation: AAC28328.1 AB013132 mRNA Translation: BAA31989.1 AF019883 mRNA Translation: AAB71543.1 |
CCDSi | CCDS21497.1 |
RefSeqi | NP_033490.1, NM_009464.3 |
3D structure databases
AlphaFoldDBi | P56501 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
CORUMi | P56501 |
STRINGi | 10090.ENSMUSP00000032958 |
PTM databases
iPTMneti | P56501 |
PhosphoSitePlusi | P56501 |
Proteomic databases
MaxQBi | P56501 |
PaxDbi | P56501 |
PRIDEi | P56501 |
ProteomicsDBi | 298428 |
Protocols and materials databases
Antibodypediai | 4388, 284 antibodies from 33 providers |
DNASUi | 22229 |
Genome annotation databases
Ensembli | ENSMUST00000032958; ENSMUSP00000032958; ENSMUSG00000032942 ENSMUST00000107059; ENSMUSP00000102674; ENSMUSG00000032942 |
GeneIDi | 22229 |
KEGGi | mmu:22229 |
UCSCi | uc009ina.1, mouse |
Organism-specific databases
CTDi | 7352 |
MGIi | MGI:1099787, Ucp3 |
VEuPathDBi | HostDB:ENSMUSG00000032942 |
Phylogenomic databases
eggNOGi | KOG0753, Eukaryota |
GeneTreei | ENSGT00940000161030 |
HOGENOMi | CLU_015166_14_2_1 |
InParanoidi | P56501 |
OMAi | DCMLKLV |
OrthoDBi | 984118at2759 |
PhylomeDBi | P56501 |
TreeFami | TF323211 |
Enzyme and pathway databases
Reactomei | R-MMU-167826, The fatty acid cycling model R-MMU-167827, The proton buffering model |
Miscellaneous databases
BioGRID-ORCSi | 22229, 5 hits in 73 CRISPR screens |
ChiTaRSi | Ucp3, mouse |
PROi | PR:P56501 |
RNActi | P56501, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032942, Expressed in hindlimb stylopod muscle and 134 other tissues |
Genevisiblei | P56501, MM |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002030, Mit_uncoupling_UCP-like IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00784, MTUNCOUPLING |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | UCP3_MOUSE | |
Accessioni | P56501Primary (citable) accession number: P56501 Secondary accession number(s): O88293 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families