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Protein

Mitochondrial uncoupling protein 3

Gene

Ucp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity).By similarity

GO - Molecular functioni

  • oxidative phosphorylation uncoupler activity Source: GO_Central
  • proton transmembrane transporter activity Source: RGD

GO - Biological processi

  • adaptive thermogenesis Source: GO_Central
  • aging Source: RGD
  • cellular response to hormone stimulus Source: RGD
  • fatty acid metabolic process Source: Ensembl
  • mitochondrial transmembrane transport Source: GO_Central
  • mitochondrial transport Source: GO_Central
  • response to activity Source: RGD
  • response to cold Source: RGD
  • response to glucocorticoid Source: RGD
  • response to hypoxia Source: HGNC
  • response to insulin Source: RGD
  • response to nutrient Source: RGD
  • response to steroid hormone Source: RGD
  • response to superoxide Source: RGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-167826 The fatty acid cycling model
R-RNO-167827 The proton buffering model

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 3
Short name:
UCP 3
Alternative name(s):
Solute carrier family 25 member 9
Gene namesi
Name:Ucp3
Synonyms:Slc25a9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3933 Ucp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Transmembranei74 – 96Helical; Name=2Sequence analysisAdd BLAST23
Transmembranei117 – 133Helical; Name=3Sequence analysisAdd BLAST17
Transmembranei180 – 196Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei214 – 233Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei268 – 290Helical; Name=6Sequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906751 – 308Mitochondrial uncoupling protein 3Add BLAST308

Proteomic databases

PaxDbiP56499
PRIDEiP56499

Expressioni

Gene expression databases

BgeeiENSRNOG00000017716
GenevisibleiP56499 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024005

Structurei

3D structure databases

ProteinModelPortaliP56499
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 102Solcar 1Add BLAST92
Repeati111 – 202Solcar 2Add BLAST92
Repeati211 – 296Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni275 – 297Purine nucleotide bindingBy similarityAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753 Eukaryota
ENOG410XRV1 LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165140
HOVERGENiHBG009528
InParanoidiP56499
KOiK15103
OMAiLRQWEGQ
OrthoDBiEOG091G0BQ7
PhylomeDBiP56499
TreeFamiTF323211

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002030 Mit_uncoupling_UCP-like
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00784 MTUNCOUPLING
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P56499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGLQPSEVP PTTVVKFLGA GTAACFADLL TFPLDTAKVR LQIQGENPGV
60 70 80 90 100
QSVQYRGVLG TILTMVRTEG PRSPYSGLVA GLHRQMSFAS IRIGLYDSVK
110 120 130 140 150
QFYTPKGTDH SSVAIRILAG CTTGAMAVTC AQPTDVVKVR FQAMIRLGTG
160 170 180 190 200
GERKYRGTMD AYRTIAREEG VRGLWKGTWP NITRNAIVNC AEMVTYDIIK
210 220 230 240 250
EKLLDSHLFT DNFPCHFVSA FGAGFCATVV ASPVDVVKTR YMNAPPGRYR
260 270 280 290 300
SPLHCMLRMV AQEGPTAFYK GFMPSFLRLG SWNVMMFVTY EQLKRALMKV

QVLRESPF
Length:308
Mass (Da):34,015
Last modified:July 15, 1998 - v1
Checksum:iF86E784530ACC555
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006614 mRNA Translation: BAA23355.1
U92069 mRNA Translation: AAB71523.1
AF035943 mRNA Translation: AAC05740.1
AF030163 mRNA Translation: AAD01891.1
BC072546 mRNA Translation: AAH72546.1
RefSeqiNP_037299.1, NM_013167.2
UniGeneiRn.9902

Genome annotation databases

EnsembliENSRNOT00000024005; ENSRNOP00000024005; ENSRNOG00000017716
GeneIDi25708
KEGGirno:25708
UCSCiRGD:3933 rat

Similar proteinsi

Entry informationi

Entry nameiUCP3_RAT
AccessioniPrimary (citable) accession number: P56499
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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