UniProtKB - P56481 (GASR_MOUSE)
Protein
Gastrin/cholecystokinin type B receptor
Gene
Cckbr
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity
GO - Molecular functioni
- cholecystokinin receptor activity Source: MGI
- gastrin receptor activity Source: UniProtKB
- peptide hormone binding Source: MGI
- type B gastrin/cholecystokinin receptor binding Source: MGI
GO - Biological processi
- apoptotic process Source: MGI
- behavioral defense response Source: MGI
- cholecystokinin signaling pathway Source: MGI
- digestive tract development Source: MGI
- ERK1 and ERK2 cascade Source: MGI
- estrous cycle Source: MGI
- gastric acid secretion Source: MGI
- gland development Source: MGI
- histamine secretion Source: MGI
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
- pH reduction Source: MGI
- positive regulation of behavioral fear response Source: MGI
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of somatostatin secretion Source: MGI
- positive regulation of synaptic transmission Source: MGI
- positive regulation of synaptic transmission, GABAergic Source: MGI
- positive regulation of synaptic transmission, glutamatergic Source: MGI
- regulation of sensory perception of pain Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-416476, G alpha (q) signalling events R-MMU-881907, Gastrin-CREB signalling pathway via PKC and MAPK |
Names & Taxonomyi
Protein namesi | Recommended name: Gastrin/cholecystokinin type B receptorShort name: CCK-B receptor Short name: CCK-BR Alternative name(s): Cholecystokinin-2 receptor Short name: CCK2-R |
Gene namesi | Name:Cckbr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99479, Cckbr |
Subcellular locationi
Plasma membrane
Nucleus
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 57 | ExtracellularSequence analysisAdd BLAST | 57 | |
Transmembranei | 58 – 79 | Helical; Name=1Sequence analysisAdd BLAST | 22 | |
Topological domaini | 80 – 87 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 88 – 109 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 110 – 131 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 132 – 150 | Helical; Name=3Sequence analysisAdd BLAST | 19 | |
Topological domaini | 151 – 170 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 171 – 189 | Helical; Name=4Sequence analysisAdd BLAST | 19 | |
Topological domaini | 190 – 219 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 220 – 242 | Helical; Name=5Sequence analysisAdd BLAST | 23 | |
Topological domaini | 243 – 339 | CytoplasmicSequence analysisAdd BLAST | 97 | |
Transmembranei | 340 – 361 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 362 – 379 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 380 – 400 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 401 – 453 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069475 | 1 – 453 | Gastrin/cholecystokinin type B receptorAdd BLAST | 453 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 7 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 30 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 36 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 127 ↔ 205 | PROSITE-ProRule annotation | ||
Lipidationi | 414 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P56481 |
PRIDEi | P56481 |
ProteomicsDBi | 267422 |
PTM databases
GlyGeni | P56481, 3 sites |
iPTMneti | P56481 |
PhosphoSitePlusi | P56481 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030898, Expressed in cingulate cortex and 101 other tissues |
Genevisiblei | P56481, MM |
Interactioni
GO - Molecular functioni
- type B gastrin/cholecystokinin receptor binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000033189 |
Chemistry databases
BindingDBi | P56481 |
Miscellaneous databases
RNActi | P56481, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230377 |
HOGENOMi | CLU_009579_6_3_1 |
InParanoidi | P56481 |
OMAi | TWRAFDN |
OrthoDBi | 1042780at2759 |
PhylomeDBi | P56481 |
TreeFami | TF315303 |
Family and domain databases
InterProi | View protein in InterPro IPR009126, Cholcskin_rcpt IPR000314, Gastrin_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01822, CCYSTOKININR PR00527, GASTRINR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P56481-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLLKLNRSL QGPGPGSGSS LCRPGVSLLN SSSAGNLSCE TPRIRGTGTR
60 70 80 90 100
ELELTIRITL YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD
110 120 130 140 150
LLLAVACMPF TLLPNLMGTF IFGTVICKAV SYLMGVSVSV STLNLAAIAL
160 170 180 190 200
ERYSAICRPL QARVWQTRSH AARVILATWL LSGLLMVPYP VYTVVQPVGP
210 220 230 240 250
RILQCMHLWP SERVQQMWSV LLLILLFFIP GVVMAVAYGL ISRELYLGLR
260 270 280 290 300
FDGDNDSETQ SRVRNQGGLP GGAAAPGPVH QNGGCRHVTS LTGEDSDGCY
310 320 330 340 350
VQLPRSRLEM TTLTTPTTGP GPGPRPNQAK LLAKKRVVRM LLVIVLLFFV
360 370 380 390 400
CWLPVYSANT WRAFDGPGAR RALAGAPISF IHLLSYTSAC ANPLVYCFMH
410 420 430 440 450
RRFRQACLDT CARCCPRPPR ARPRPLPDED PPTPSIASLS RLSYTTISTL
GPG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ8BYG7 | Q8BYG7_MOUSE | Cholecystokinin-2 receptor | Cckbr | 314 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF019371 mRNA Translation: AAB71863.1 AF264178, AF264177 Genomic DNA Translation: AAG09801.1 AK028325 mRNA Translation: BAC25881.1 |
CCDSi | CCDS21651.1 |
RefSeqi | NP_031653.1, NM_007627.5 |
Genome annotation databases
Ensembli | ENSMUST00000033189; ENSMUSP00000033189; ENSMUSG00000030898 |
GeneIDi | 12426 |
KEGGi | mmu:12426 |
UCSCi | uc009iyd.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF019371 mRNA Translation: AAB71863.1 AF264178, AF264177 Genomic DNA Translation: AAG09801.1 AK028325 mRNA Translation: BAC25881.1 |
CCDSi | CCDS21651.1 |
RefSeqi | NP_031653.1, NM_007627.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000033189 |
Chemistry databases
BindingDBi | P56481 |
ChEMBLi | CHEMBL2854 |
DrugCentrali | P56481 |
GuidetoPHARMACOLOGYi | 77 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P56481, 3 sites |
iPTMneti | P56481 |
PhosphoSitePlusi | P56481 |
Proteomic databases
PaxDbi | P56481 |
PRIDEi | P56481 |
ProteomicsDBi | 267422 |
Protocols and materials databases
Antibodypediai | 11193, 353 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000033189; ENSMUSP00000033189; ENSMUSG00000030898 |
GeneIDi | 12426 |
KEGGi | mmu:12426 |
UCSCi | uc009iyd.1, mouse |
Organism-specific databases
CTDi | 887 |
MGIi | MGI:99479, Cckbr |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230377 |
HOGENOMi | CLU_009579_6_3_1 |
InParanoidi | P56481 |
OMAi | TWRAFDN |
OrthoDBi | 1042780at2759 |
PhylomeDBi | P56481 |
TreeFami | TF315303 |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-416476, G alpha (q) signalling events R-MMU-881907, Gastrin-CREB signalling pathway via PKC and MAPK |
Miscellaneous databases
BioGRID-ORCSi | 12426, 0 hits in 53 CRISPR screens |
PROi | PR:P56481 |
RNActi | P56481, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030898, Expressed in cingulate cortex and 101 other tissues |
Genevisiblei | P56481, MM |
Family and domain databases
InterProi | View protein in InterPro IPR009126, Cholcskin_rcpt IPR000314, Gastrin_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01822, CCYSTOKININR PR00527, GASTRINR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GASR_MOUSE | |
Accessioni | P56481Primary (citable) accession number: P56481 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | April 7, 2021 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families