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Protein

Gastrin/cholecystokinin type B receptor

Gene

Cckbr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-881907 Gastrin-CREB signalling pathway via PKC and MAPK

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin/cholecystokinin type B receptor
Short name:
CCK-B receptor
Short name:
CCK-BR
Alternative name(s):
Cholecystokinin-2 receptor
Short name:
CCK2-R
Gene namesi
Name:Cckbr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99479 Cckbr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 79Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini80 – 87CytoplasmicSequence analysis8
Transmembranei88 – 109Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini110 – 131ExtracellularSequence analysisAdd BLAST22
Transmembranei132 – 150Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini151 – 170CytoplasmicSequence analysisAdd BLAST20
Transmembranei171 – 189Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini190 – 219ExtracellularSequence analysisAdd BLAST30
Transmembranei220 – 242Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini243 – 339CytoplasmicSequence analysisAdd BLAST97
Transmembranei340 – 361Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini362 – 379ExtracellularSequence analysisAdd BLAST18
Transmembranei380 – 400Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini401 – 453CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2854
GuidetoPHARMACOLOGYi77

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694751 – 453Gastrin/cholecystokinin type B receptorAdd BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127 ↔ 205PROSITE-ProRule annotation
Lipidationi414S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP56481
PRIDEiP56481

PTM databases

iPTMnetiP56481
PhosphoSitePlusiP56481

Expressioni

Gene expression databases

BgeeiENSMUSG00000030898
CleanExiMM_CCKBR
ExpressionAtlasiP56481 baseline and differential
GenevisibleiP56481 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033189

Chemistry databases

BindingDBiP56481

Structurei

3D structure databases

ProteinModelPortaliP56481
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00920000148959
HOGENOMiHOG000294067
HOVERGENiHBG036927
InParanoidiP56481
KOiK04195
OMAiWRAFDGP
OrthoDBiEOG091G084J
PhylomeDBiP56481
TreeFamiTF315303

Family and domain databases

InterProiView protein in InterPro
IPR009126 Cholcskin_rcpt
IPR000314 Gastrin_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01822 CCYSTOKININR
PR00527 GASTRINR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P56481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLKLNRSL QGPGPGSGSS LCRPGVSLLN SSSAGNLSCE TPRIRGTGTR
60 70 80 90 100
ELELTIRITL YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD
110 120 130 140 150
LLLAVACMPF TLLPNLMGTF IFGTVICKAV SYLMGVSVSV STLNLAAIAL
160 170 180 190 200
ERYSAICRPL QARVWQTRSH AARVILATWL LSGLLMVPYP VYTVVQPVGP
210 220 230 240 250
RILQCMHLWP SERVQQMWSV LLLILLFFIP GVVMAVAYGL ISRELYLGLR
260 270 280 290 300
FDGDNDSETQ SRVRNQGGLP GGAAAPGPVH QNGGCRHVTS LTGEDSDGCY
310 320 330 340 350
VQLPRSRLEM TTLTTPTTGP GPGPRPNQAK LLAKKRVVRM LLVIVLLFFV
360 370 380 390 400
CWLPVYSANT WRAFDGPGAR RALAGAPISF IHLLSYTSAC ANPLVYCFMH
410 420 430 440 450
RRFRQACLDT CARCCPRPPR ARPRPLPDED PPTPSIASLS RLSYTTISTL

GPG
Length:453
Mass (Da):49,172
Last modified:July 15, 1998 - v1
Checksum:iDFD21432C323405C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019371 mRNA Translation: AAB71863.1
AF264178, AF264177 Genomic DNA Translation: AAG09801.1
AK028325 mRNA Translation: BAC25881.1
CCDSiCCDS21651.1
RefSeqiNP_031653.1, NM_007627.5
UniGeneiMm.44513

Genome annotation databases

EnsembliENSMUST00000033189; ENSMUSP00000033189; ENSMUSG00000030898
GeneIDi12426
KEGGimmu:12426
UCSCiuc009iyd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGASR_MOUSE
AccessioniPrimary (citable) accession number: P56481
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: June 20, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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