UniProtKB - P56480 (ATPB_MOUSE)
ATP synthase subunit beta, mitochondrial
Atp5f1b
Functioni
Catalytic activityi
- EC:7.1.2.2
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 239 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 207 – 214 | ATPBy similarity | 8 |
GO - Molecular functioni
- ADP binding Source: MGI
- angiostatin binding Source: MGI
- ATPase activity Source: MGI
- ATP binding Source: MGI
- calcium ion binding Source: MGI
- lipoprotein particle receptor activity Source: MGI
- MHC class I protein binding Source: MGI
- proton-transporting ATPase activity, rotational mechanism Source: MGI
- proton-transporting ATP synthase activity, rotational mechanism Source: MGI
GO - Biological processi
- angiogenesis Source: MGI
- ATP biosynthetic process Source: MGI
- ATP metabolic process Source: MGI
- cellular response to interleukin-7 Source: MGI
- lipid metabolic process Source: MGI
- mitochondrial ATP synthesis coupled proton transport Source: MGI
- negative regulation of cell adhesion involved in substrate-bound cell migration Source: MGI
- positive regulation of blood vessel endothelial cell migration Source: MGI
- proton transmembrane transport Source: MGI
- receptor-mediated endocytosis Source: MGI
- regulation of intracellular pH Source: MGI
Keywordsi
Molecular function | Translocase |
Biological process | ATP synthesis, Hydrogen ion transport, Ion transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-1268020, Mitochondrial protein import R-MMU-163210, Formation of ATP by chemiosmotic coupling R-MMU-8949613, Cristae formation |
Names & Taxonomyi
Protein namesi | Recommended name: ATP synthase subunit beta, mitochondrialCurated (EC:7.1.2.2)Alternative name(s): ATP synthase F1 subunit betaBy similarity |
Gene namesi | Name:Atp5f1bBy similarity Synonyms:Atp5b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107801, Atp5b |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity
Mitochondrion
- mitochondrial inner membrane Source: MGI
- mitochondrial membrane Source: MGI
- mitochondrial nucleoid Source: MGI
- mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
- mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) Source: MGI
- mitochondrion Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- membrane Source: MGI
- membrane raft Source: MGI
- myelin sheath Source: UniProtKB
- proton-transporting ATP synthase complex Source: MGI
- proton-transporting ATP synthase complex, catalytic core F(1) Source: MGI
Keywords - Cellular componenti
CF(1), Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 46 | MitochondrionBy similarityAdd BLAST | 46 | |
ChainiPRO_0000002444 | 47 – 529 | ATP synthase subunit beta, mitochondrialAdd BLAST | 483 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 106 | O-linked (GlcNAc) serineBy similarity | 1 | |
Modified residuei | 124 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 124 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 133 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 133 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 161 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 161 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 198 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 259 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 259 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 264 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 264 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 312 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 426 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 433 | PhosphoserineBy similarity | 1 | |
Modified residuei | 480 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 485 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 522 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 522 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 529 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3766 |
EPDi | P56480 |
jPOSTi | P56480 |
MaxQBi | P56480 |
PaxDbi | P56480 |
PeptideAtlasi | P56480 |
PRIDEi | P56480 |
TopDownProteomicsi | P56480 |
2D gel databases
COMPLUYEAST-2DPAGEi | P56480 |
REPRODUCTION-2DPAGEi | IPI00468481 P56480 |
SWISS-2DPAGEi | P56480 |
UCD-2DPAGEi | P56480 |
PTM databases
CarbonylDBi | P56480 |
GlyGeni | P56480, 1 site |
iPTMneti | P56480 |
PhosphoSitePlusi | P56480 |
SwissPalmi | P56480 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025393, Expressed in central gray substance of midbrain and 318 other tissues |
Genevisiblei | P56480, MM |
Interactioni
Subunit structurei
F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.
Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and ATP5MPL (By similarity).
Interacts with PPIF (PubMed:21281446).
Interacts with BCL2L1 isoform BCL-X(L); the interaction mediates the association of BCL2L1 isoform BCL-X(L) with the mitochondrial membrane F1F0 ATP synthase and enhances neurons metabolic efficiency (By similarity).
Interacts with CLN5 and PPT1 (PubMed:19941651).
By similarity2 PublicationsGO - Molecular functioni
- angiostatin binding Source: MGI
- MHC class I protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198254, 55 interactors |
IntActi | P56480, 38 interactors |
MINTi | P56480 |
STRINGi | 10090.ENSMUSP00000026459 |
Miscellaneous databases
RNActi | P56480, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1350, Eukaryota |
GeneTreei | ENSGT00550000074800 |
HOGENOMi | CLU_022398_0_2_1 |
InParanoidi | P56480 |
OMAi | FNMIMDG |
OrthoDBi | 495235at2759 |
PhylomeDBi | P56480 |
TreeFami | TF105640 |
Family and domain databases
Gene3Di | 1.10.1140.10, 1 hit |
HAMAPi | MF_01347, ATP_synth_beta_bact, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR005722, ATP_synth_F1_bsu IPR020003, ATPase_a/bsu_AS IPR004100, ATPase_F1/V1/A1_a/bsu_N IPR036121, ATPase_F1/V1/A1_a/bsu_N_sf IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd IPR024034, ATPase_F1/V1_b/a_C IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00006, ATP-synt_ab, 1 hit PF02874, ATP-synt_ab_N, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF50615, SSF50615, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01039, atpD, 1 hit |
PROSITEi | View protein in PROSITE PS00152, ATPASE_ALPHA_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MLSLVGRVAS ASASGALRGL SPSAALPQAQ LLLRAAPAGV HPARDYAAQA
60 70 80 90 100
SAAPKAGTAT GRIVAVIGAV VDVQFDEGLP PILNALEVQG RDSRLVLEVA
110 120 130 140 150
QHLGESTVRT IAMDGTEGLV RGQKVLDSGA PIKIPVGPET LGRIMNVIGE
160 170 180 190 200
PIDERGPIKT KQFAPIHAEA PEFIEMSVEQ EILVTGIKVV DLLAPYAKGG
210 220 230 240 250
KIGLFGGAGV GKTVLIMELI NNVAKAHGGY SVFAGVGERT REGNDLYHEM
260 270 280 290 300
IESGVINLKD ATSKVALVYG QMNEPPGARA RVALTGLTVA EYFRDQEGQD
310 320 330 340 350
VLLFIDNIFR FTQAGSEVSA LLGRIPSAVG YQPTLATDMG TMQERITTTK
360 370 380 390 400
KGSITSVQAI YVPADDLTDP APATTFAHLD ATTVLSRAIA ELGIYPAVDP
410 420 430 440 450
LDSTSRIMDP NIVGNEHYDV ARGVQKILQD YKSLQDIIAI LGMDELSEED
460 470 480 490 500
KLTVSRARKI QRFLSQPFQV AEVFTGHMGK LVPLKETIKG FQQILAGEYD
510 520
HLPEQAFYMV GPIEEAVAKA DKLAEEHGS
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 | A → V in AAB86421 (PubMed:10657236).Curated | 1 | |
Sequence conflicti | 43 | A → V in BAE35088 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 76 | D → G in BAE40961 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 92 | D → E in AAB86421 (PubMed:10657236).Curated | 1 | |
Sequence conflicti | 134 | I → V in BAE31497 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 239 | R → K in AAB86421 (PubMed:10657236).Curated | 1 | |
Sequence conflicti | 271 | Q → R in BAE38888 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 271 | Q → R in BAE39301 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 279 – 280 | RA → PT in AAB86421 (PubMed:10657236).Curated | 2 | |
Sequence conflicti | 288 | T → A in BAE31497 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 288 | T → A in BAE31630 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 375 | T → N in BAE30095 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 383 | T → S in BAB22802 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 433 – 434 | SL → FF in AAB86421 (PubMed:10657236).Curated | 2 | |
Sequence conflicti | 466 | Q → H in BAB22802 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 469 | Q → R in BAE39797 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 518 | A → V in BAE35331 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF030559 mRNA Translation: AAB86421.1 AK003460 mRNA Translation: BAB22802.1 AK010314 mRNA Translation: BAB26846.1 AK084009 mRNA Translation: BAC39095.1 AK145684 mRNA Translation: BAE26587.1 AK148891 mRNA Translation: BAE28692.1 AK150599 mRNA Translation: BAE29691.1 AK151081 mRNA Translation: BAE30095.1 AK151600 mRNA Translation: BAE30540.1 AK152788 mRNA Translation: BAE31497.1 AK152976 mRNA Translation: BAE31630.1 AK153099 mRNA Translation: BAE31720.1 AK159444 mRNA Translation: BAE35088.1 AK159737 mRNA Translation: BAE35331.1 AK159978 mRNA Translation: BAE35529.1 AK160199 mRNA Translation: BAE35689.1 AK160608 mRNA Translation: BAE35911.1 AK164383 mRNA Translation: BAE37764.1 AK166525 mRNA Translation: BAE38829.1 AK166603 mRNA Translation: BAE38888.1 AK166979 mRNA Translation: BAE39161.1 AK167119 mRNA Translation: BAE39267.1 AK167160 mRNA Translation: BAE39301.1 AK167728 mRNA Translation: BAE39769.1 AK167764 mRNA Translation: BAE39797.1 AK168692 mRNA Translation: BAE40537.1 AK168941 mRNA Translation: BAE40749.1 AK169184 mRNA Translation: BAE40961.1 BC018392 mRNA Translation: AAH18392.1 BC037127 mRNA Translation: AAH37127.1 Different initiation. BC046616 mRNA Translation: AAH46616.1 DQ403100 mRNA Translation: ABD77233.1 |
CCDSi | CCDS24259.1 |
RefSeqi | NP_058054.2, NM_016774.3 |
Genome annotation databases
Ensembli | ENSMUST00000026459; ENSMUSP00000026459; ENSMUSG00000025393 |
GeneIDi | 11947 |
KEGGi | mmu:11947 |
UCSCi | uc007hle.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF030559 mRNA Translation: AAB86421.1 AK003460 mRNA Translation: BAB22802.1 AK010314 mRNA Translation: BAB26846.1 AK084009 mRNA Translation: BAC39095.1 AK145684 mRNA Translation: BAE26587.1 AK148891 mRNA Translation: BAE28692.1 AK150599 mRNA Translation: BAE29691.1 AK151081 mRNA Translation: BAE30095.1 AK151600 mRNA Translation: BAE30540.1 AK152788 mRNA Translation: BAE31497.1 AK152976 mRNA Translation: BAE31630.1 AK153099 mRNA Translation: BAE31720.1 AK159444 mRNA Translation: BAE35088.1 AK159737 mRNA Translation: BAE35331.1 AK159978 mRNA Translation: BAE35529.1 AK160199 mRNA Translation: BAE35689.1 AK160608 mRNA Translation: BAE35911.1 AK164383 mRNA Translation: BAE37764.1 AK166525 mRNA Translation: BAE38829.1 AK166603 mRNA Translation: BAE38888.1 AK166979 mRNA Translation: BAE39161.1 AK167119 mRNA Translation: BAE39267.1 AK167160 mRNA Translation: BAE39301.1 AK167728 mRNA Translation: BAE39769.1 AK167764 mRNA Translation: BAE39797.1 AK168692 mRNA Translation: BAE40537.1 AK168941 mRNA Translation: BAE40749.1 AK169184 mRNA Translation: BAE40961.1 BC018392 mRNA Translation: AAH18392.1 BC037127 mRNA Translation: AAH37127.1 Different initiation. BC046616 mRNA Translation: AAH46616.1 DQ403100 mRNA Translation: ABD77233.1 |
CCDSi | CCDS24259.1 |
RefSeqi | NP_058054.2, NM_016774.3 |
3D structure databases
SMRi | P56480 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198254, 55 interactors |
IntActi | P56480, 38 interactors |
MINTi | P56480 |
STRINGi | 10090.ENSMUSP00000026459 |
PTM databases
CarbonylDBi | P56480 |
GlyGeni | P56480, 1 site |
iPTMneti | P56480 |
PhosphoSitePlusi | P56480 |
SwissPalmi | P56480 |
2D gel databases
COMPLUYEAST-2DPAGEi | P56480 |
REPRODUCTION-2DPAGEi | IPI00468481 P56480 |
SWISS-2DPAGEi | P56480 |
UCD-2DPAGEi | P56480 |
Proteomic databases
CPTACi | non-CPTAC-3766 |
EPDi | P56480 |
jPOSTi | P56480 |
MaxQBi | P56480 |
PaxDbi | P56480 |
PeptideAtlasi | P56480 |
PRIDEi | P56480 |
TopDownProteomicsi | P56480 |
Protocols and materials databases
Antibodypediai | 877, 509 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000026459; ENSMUSP00000026459; ENSMUSG00000025393 |
GeneIDi | 11947 |
KEGGi | mmu:11947 |
UCSCi | uc007hle.1, mouse |
Organism-specific databases
CTDi | 11947 |
MGIi | MGI:107801, Atp5b |
Phylogenomic databases
eggNOGi | KOG1350, Eukaryota |
GeneTreei | ENSGT00550000074800 |
HOGENOMi | CLU_022398_0_2_1 |
InParanoidi | P56480 |
OMAi | FNMIMDG |
OrthoDBi | 495235at2759 |
PhylomeDBi | P56480 |
TreeFami | TF105640 |
Enzyme and pathway databases
Reactomei | R-MMU-1268020, Mitochondrial protein import R-MMU-163210, Formation of ATP by chemiosmotic coupling R-MMU-8949613, Cristae formation |
Miscellaneous databases
BioGRID-ORCSi | 11947, 10 hits in 20 CRISPR screens |
ChiTaRSi | Atp5b, mouse |
PROi | PR:P56480 |
RNActi | P56480, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025393, Expressed in central gray substance of midbrain and 318 other tissues |
Genevisiblei | P56480, MM |
Family and domain databases
Gene3Di | 1.10.1140.10, 1 hit |
HAMAPi | MF_01347, ATP_synth_beta_bact, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR005722, ATP_synth_F1_bsu IPR020003, ATPase_a/bsu_AS IPR004100, ATPase_F1/V1/A1_a/bsu_N IPR036121, ATPase_F1/V1/A1_a/bsu_N_sf IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd IPR024034, ATPase_F1/V1_b/a_C IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00006, ATP-synt_ab, 1 hit PF02874, ATP-synt_ab_N, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF50615, SSF50615, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01039, atpD, 1 hit |
PROSITEi | View protein in PROSITE PS00152, ATPASE_ALPHA_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATPB_MOUSE | |
Accessioni | P56480Primary (citable) accession number: P56480 Secondary accession number(s): Q0QEP4 Q9CWX7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | May 2, 2002 | |
Last modified: | December 2, 2020 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families