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Protein

Galanin receptor type 1

Gene

Galr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 1
Short name:
GAL1-R
Short name:
GALR-1
Gene namesi
Name:Galr1
Synonyms:Galnr, Galnr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1096364 Galr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini56 – 70CytoplasmicSequence analysisAdd BLAST15
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 109ExtracellularSequence analysisAdd BLAST18
Transmembranei110 – 131Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini132 – 151CytoplasmicSequence analysisAdd BLAST20
Transmembranei152 – 172Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini173 – 197ExtracellularSequence analysisAdd BLAST25
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 247CytoplasmicSequence analysisAdd BLAST29
Transmembranei248 – 268Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini269 – 270ExtracellularSequence analysis2
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 348CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi243

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694641 – 348Galanin receptor type 1Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi108 ↔ 186PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi319S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Three cysteine residues are found in the C-terminus, at least one of which may be palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP56479
PRIDEiP56479

PTM databases

PhosphoSitePlusiP56479

Expressioni

Tissue specificityi

Expression is detected in brain, spinal cord, heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000024553 Expressed in 29 organ(s), highest expression level in islet of Langerhans
CleanExiMM_GALR1
GenevisibleiP56479 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066381

Structurei

3D structure databases

ProteinModelPortaliP56479
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00920000148959
HOGENOMiHOG000230487
HOVERGENiHBG101447
InParanoidiP56479
KOiK04230
OMAiKQVFKCH
OrthoDBiEOG091G0ZDG
PhylomeDBiP56479
TreeFamiTF315737

Family and domain databases

CDDicd15098 7tmA_Gal1_R, 1 hit
InterProiView protein in InterPro
IPR003906 GAL1_rcpt
IPR000405 Galanin_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01418 GALANIN1R
PR00663 GALANINR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P56479-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELAMVNLSE GNGSDPEPPA PESRPLFGIG VENFITLVVF GLIFAMGVLG
60 70 80 90 100
NSLVITVLAR SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT
110 120 130 140 150
WVLGAFICKF IHYFFTVSML VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR
160 170 180 190 200
NALLGVGFIW ALSIAMASPV AYHQRLFHRD SNQTFCWEQW PNKLHKKAYV
210 220 230 240 250
VCTFVFGYLL PLLLICFCYA KVLNHLHKKL KNMSKKSEAS KKKTAQTVLV
260 270 280 290 300
VVVVFGISWL PHHVVHLWAE FGAFPLTPAS FFFRITAHCL AYSNSSVNPI
310 320 330 340
IYAFLSENFR KAYKQVFKCH VCDESPRSET KENKSRMDTP PSTNCTHV
Length:348
Mass (Da):39,114
Last modified:July 15, 1998 - v1
Checksum:i6F52D752BAA19F9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15004 mRNA Translation: CAA75237.1
U90657, U90655, U90656 Genomic DNA Translation: AAB87748.1
CCDSiCCDS29372.1
RefSeqiNP_032108.1, NM_008082.2
UniGeneiMm.6219

Genome annotation databases

EnsembliENSMUST00000065224; ENSMUSP00000066381; ENSMUSG00000024553
GeneIDi14427
KEGGimmu:14427
UCSCiuc008ftq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGALR1_MOUSE
AccessioniPrimary (citable) accession number: P56479
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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