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Protein

Interferon regulatory factor 5

Gene

Irf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi14 – 122IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST109

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processAntiviral defense, Immunity, Innate immunity, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 5
Short name:
IRF-5
Gene namesi
Name:Irf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1350924 Irf5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545591 – 497Interferon regulatory factor 5Add BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei157Phosphoserine; by TBK1By similarity1
Modified residuei300PhosphoserineBy similarity1
Cross-linki410Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki411Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei434PhosphoserineBy similarity1
Modified residuei436PhosphoserineBy similarity1
Modified residuei439PhosphoserineBy similarity1
Modified residuei445PhosphoserineBy similarity1

Post-translational modificationi

'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.1 Publication
Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP56477
PeptideAtlasiP56477
PRIDEiP56477

PTM databases

iPTMnetiP56477
PhosphoSitePlusiP56477

Expressioni

Gene expression databases

BgeeiENSMUSG00000029771 Expressed in 152 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_IRF5
ExpressionAtlasiP56477 baseline and differential
GenevisibleiP56477 MM

Interactioni

Subunit structurei

Homodimer, when phosphorylated.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205111, 4 interactors
DIPiDIP-49382N
IntActiP56477, 3 interactors
STRINGi10090.ENSMUSP00000004392

Structurei

3D structure databases

ProteinModelPortaliP56477
SMRiP56477
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 18Nuclear localization signalBy similarity7
Motifi149 – 159Nuclear export signalBy similarityAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 12Poly-Pro4
Compositional biasi140 – 148Poly-Glu9

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFCV Eukaryota
ENOG410XRXT LUCA
GeneTreeiENSGT00760000119093
HOGENOMiHOG000037433
HOVERGENiHBG105715
InParanoidiP56477
KOiK09446
OMAiSHPNPIQ
OrthoDBiEOG091G067P
PhylomeDBiP56477
TreeFamiTF328512

Family and domain databases

CDDicd00103 IRF, 1 hit
Gene3Di1.10.10.10, 1 hit
2.60.200.10, 1 hit
InterProiView protein in InterPro
IPR019817 Interferon_reg_fac_CS
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR019471 Interferon_reg_factor-3
IPR029838 IRF5
IPR017855 SMAD-like_dom_sf
IPR008984 SMAD_FHA_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11949 PTHR11949, 1 hit
PTHR11949:SF10 PTHR11949:SF10, 1 hit
PfamiView protein in Pfam
PF00605 IRF, 1 hit
PF10401 IRF-3, 1 hit
PRINTSiPR00267 INTFRNREGFCT
SMARTiView protein in SMART
SM00348 IRF, 1 hit
SM01243 IRF-3, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS00601 IRF_1, 1 hit
PS51507 IRF_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P56477-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNHSAPGIPP PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFYIPWRHA
60 70 80 90 100
TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF
110 120 130 140 150
QLFYDGPRDM PPQPYKIYEV CSNGPAPTES QPTDDYVLGE EEEEEEEELQ
160 170 180 190 200
RMLPGLSITE PALPGPPNAP YSLPKEDTKW PPALQPPVGL GPPVPDPNLL
210 220 230 240 250
APPSGNPAGF RQLLPEVLEP GPLASSQPPT EPLLPDLLIS PHMLPLTDLE
260 270 280 290 300
IKFQYRGRAP RTLTISNPQG CRLFYSQLEA TQEQVELFGP VTLEQVRFPS
310 320 330 340 350
PEDIPSDKQR FYTNQLLDVL DRGLILQLQG QDLYAIRLCQ CKVFWSGPCA
360 370 380 390 400
LAHGSCPNPI QREVKTKLFS LEQFLNELIL FQKGQTNTPP PFEIFFCFGE
410 420 430 440 450
EWPDVKPREK KLITVQVVPV AARLLLEMFS GELSWSADSI RLQISNPDLK
460 470 480 490
DHMVEQFKEL HHLWQSQQQL QPMVQAPPVA GLDASQGPWP MHPVGMQ
Length:497
Mass (Da):56,005
Last modified:July 15, 1998 - v1
Checksum:iD8BD54DB946E354F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Z6C6F6Z6C6_MOUSE
Interferon regulatory factor 5
Irf5
494Annotation score:
E9Q5T2E9Q5T2_MOUSE
Interferon regulatory factor 5
Irf5
80Annotation score:
A0A0N4SVY5A0A0N4SVY5_MOUSE
Interferon regulatory factor 5
Irf5
134Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028725 mRNA Translation: AAB81997.1
CCDSiCCDS19962.1
RefSeqiNP_001239311.1, NM_001252382.1
NP_036187.1, NM_012057.4
XP_006505160.1, XM_006505097.1
UniGeneiMm.6479

Genome annotation databases

EnsembliENSMUST00000004392; ENSMUSP00000004392; ENSMUSG00000029771
ENSMUST00000163511; ENSMUSP00000127021; ENSMUSG00000029771
GeneIDi27056
KEGGimmu:27056
UCSCiuc009bdu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028725 mRNA Translation: AAB81997.1
CCDSiCCDS19962.1
RefSeqiNP_001239311.1, NM_001252382.1
NP_036187.1, NM_012057.4
XP_006505160.1, XM_006505097.1
UniGeneiMm.6479

3D structure databases

ProteinModelPortaliP56477
SMRiP56477
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205111, 4 interactors
DIPiDIP-49382N
IntActiP56477, 3 interactors
STRINGi10090.ENSMUSP00000004392

PTM databases

iPTMnetiP56477
PhosphoSitePlusiP56477

Proteomic databases

PaxDbiP56477
PeptideAtlasiP56477
PRIDEiP56477

Protocols and materials databases

DNASUi27056
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004392; ENSMUSP00000004392; ENSMUSG00000029771
ENSMUST00000163511; ENSMUSP00000127021; ENSMUSG00000029771
GeneIDi27056
KEGGimmu:27056
UCSCiuc009bdu.2 mouse

Organism-specific databases

CTDi3663
MGIiMGI:1350924 Irf5

Phylogenomic databases

eggNOGiENOG410IFCV Eukaryota
ENOG410XRXT LUCA
GeneTreeiENSGT00760000119093
HOGENOMiHOG000037433
HOVERGENiHBG105715
InParanoidiP56477
KOiK09446
OMAiSHPNPIQ
OrthoDBiEOG091G067P
PhylomeDBiP56477
TreeFamiTF328512

Miscellaneous databases

PROiPR:P56477
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029771 Expressed in 152 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_IRF5
ExpressionAtlasiP56477 baseline and differential
GenevisibleiP56477 MM

Family and domain databases

CDDicd00103 IRF, 1 hit
Gene3Di1.10.10.10, 1 hit
2.60.200.10, 1 hit
InterProiView protein in InterPro
IPR019817 Interferon_reg_fac_CS
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR019471 Interferon_reg_factor-3
IPR029838 IRF5
IPR017855 SMAD-like_dom_sf
IPR008984 SMAD_FHA_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11949 PTHR11949, 1 hit
PTHR11949:SF10 PTHR11949:SF10, 1 hit
PfamiView protein in Pfam
PF00605 IRF, 1 hit
PF10401 IRF-3, 1 hit
PRINTSiPR00267 INTFRNREGFCT
SMARTiView protein in SMART
SM00348 IRF, 1 hit
SM01243 IRF-3, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS00601 IRF_1, 1 hit
PS51507 IRF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIRF5_MOUSE
AccessioniPrimary (citable) accession number: P56477
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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