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Protein

Gamma-aminobutyric acid receptor subunit rho-2

Gene

Gabrr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • chloride transport Source: MGI
  • gamma-aminobutyric acid signaling pathway Source: MGI
  • visual perception Source: MGI

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-MMU-977442 GABA A (rho) receptor activation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-2
Alternative name(s):
GABA(A) receptor subunit rho-2
GABA(C) receptor
Gene namesi
Name:Gabrr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95626 Gabrr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 260ExtracellularCuratedAdd BLAST240
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Topological domaini347 – 443CytoplasmicCuratedAdd BLAST97
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000048921 – 465Gamma-aminobutyric acid receptor subunit rho-2Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi178 ↔ 192By similarity
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP56476
PRIDEiP56476

PTM databases

PhosphoSitePlusiP56476

Expressioni

Gene expression databases

BgeeiENSMUSG00000023267
ExpressionAtlasiP56476 baseline and differential
GenevisibleiP56476 MM

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024035

Structurei

3D structure databases

ProteinModelPortaliP56476
SMRiP56476
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOGENOMiHOG000231335
HOVERGENiHBG051707
InParanoidiP56476
KOiK05190
OMAiEKFPCMC
OrthoDBiEOG091G0805
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008059 GABAAa_rho2_rcpt
IPR008057 GABAAa_rho_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01670 GABAARRHO
PR01672 GABAARRHO2
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: P56476-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPYLMRLALV LFCLMALVES RKPRRKRWTG LLETSKPSHL YKKNLDVTKM
60 70 80 90 100
RPGKPRPLLR VEDHDFTMRP AFGGPAIPVG VDVQVESLDS ISEVDMDFTM
110 120 130 140 150
TLYLRHYWRD ERLAFPSSSN KSMTFDGRLV KKIWVPDVFF VHSKRSFIHD
160 170 180 190 200
TTTDNIMLRV FPDGHVLYSM RITVTAMCNM DFSHFPLDSQ TCSLELESYA
210 220 230 240 250
YTDEDLMLYW KNGDESLKTD EKISLSQFLI QKFHTTSRLA FYSSTGWYNR
260 270 280 290 300
LYINFTLRRH IFFFLLQTYF PATLMVMLSW VSFWIDHRAV PARVSLGIMT
310 320 330 340 350
VLTMSTIITG VNASMPRVSY IRAVDIYLWV SFVFVFLSVL EYAAVNYLTT
360 370 380 390 400
LQEQKERKFR EKLPCMCGML HSRTMMLDGS YSESEANSLA GYPRSHILPE
410 420 430 440 450
EERPDNIVVH LALNSELTSS RKKGLLKGQM GLYIFQNTHA IDKYSRLIFP
460
AFYIVFNLIY WSVFS
Length:465
Mass (Da):54,231
Last modified:October 31, 2012 - v4
Checksum:iB44B51B572468A20
GO
Isoform 2 (identifier: P56476-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVKPGGILPIKSPCTAACCIIDMCRM

Note: Isoform 2 could be translated from an upstream initiator ATG located in frame within the first coding exon. The probability of a signal peptide within this isoform is very low. No experimental confirmation available.
Show »
Length:490
Mass (Da):56,834
Checksum:i18BBEDC2346C52D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33E → D in AAB81965 (Ref. 1) Curated1
Sequence conflicti52P → A in AAB81965 (Ref. 1) Curated1
Sequence conflicti59L → F in AAB81965 (Ref. 1) Curated1
Sequence conflicti88L → V in AAB81965 (Ref. 1) Curated1
Sequence conflicti105R → K in AAB81965 (Ref. 1) Curated1
Sequence conflicti109R → K in AAB81965 (Ref. 1) Curated1
Sequence conflicti149H → Q in AAB81965 (Ref. 1) Curated1
Sequence conflicti357R → L in AAB81965 (Ref. 1) Curated1
Sequence conflicti366M → V in AAB81965 (Ref. 1) Curated1
Sequence conflicti372S → A in AAB81965 (Ref. 1) Curated1
Sequence conflicti394R → T in AAB81965 (Ref. 1) Curated1
Sequence conflicti400E → K in AAB81965 (Ref. 1) Curated1
Sequence conflicti421R → K in AAB81965 (Ref. 1) Curated1
Sequence conflicti429Q → R in AAB81965 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0443741M → MVKPGGILPIKSPCTAACCI IDMCRM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024621 mRNA Translation: AAB81965.1
CH466538 Genomic DNA Translation: EDL05492.1
BC057957 mRNA Translation: AAH57957.2
CCDSiCCDS18020.1 [P56476-2]
RefSeqiNP_032102.2, NM_008076.3 [P56476-2]
UniGeneiMm.6227

Genome annotation databases

EnsembliENSMUST00000024035; ENSMUSP00000024035; ENSMUSG00000023267 [P56476-2]
ENSMUST00000108162; ENSMUSP00000103797; ENSMUSG00000023267 [P56476-1]
GeneIDi14409
KEGGimmu:14409
UCSCiuc008sfq.1 mouse [P56476-2]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiGBRR2_MOUSE
AccessioniPrimary (citable) accession number: P56476
Secondary accession number(s): Q6PEP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 31, 2012
Last modified: June 20, 2018
This is version 147 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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