UniProtKB - P56475 (GBRR1_MOUSE)
Protein
Gamma-aminobutyric acid receptor subunit rho-1
Gene
Gabrr1
Organism
Mus musculus (Mouse)
Status
Functioni
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission (By similarity).By similarity
GO - Molecular functioni
- chloride channel activity Source: UniProtKB-KW
- GABA-A receptor activity Source: InterPro
- GABA receptor activity Source: MGI
- identical protein binding Source: MGI
- ligand-gated ion channel activity involved in regulation of presynaptic membrane potential Source: SynGO
- neurotransmitter receptor activity Source: GO_Central
- protein-containing complex binding Source: MGI
- protein domain specific binding Source: MGI
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: SynGO
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: GO_Central
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- regulation of membrane potential Source: GO_Central
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Chloride channel, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Enzyme and pathway databases
Reactomei | R-MMU-977443, GABA receptor activation |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-aminobutyric acid receptor subunit rho-1Alternative name(s): GABA(A) receptor subunit rho-1 GABA(C) receptor |
Gene namesi | Name:Gabrr1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95625, Gabrr1 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane By similarity; Multi-pass membrane protein By similarity
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- chloride channel complex Source: UniProtKB-KW
- GABA-A receptor complex Source: GO_Central
- GABA-ergic synapse Source: SynGO
- glutamatergic synapse Source: SynGO
- neuron projection Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 282 | ExtracellularCuratedAdd BLAST | 261 | |
Transmembranei | 283 – 306 | HelicalCuratedAdd BLAST | 24 | |
Transmembranei | 310 – 332 | HelicalCuratedAdd BLAST | 23 | |
Transmembranei | 344 – 366 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 367 – 458 | CytoplasmicCuratedAdd BLAST | 92 | |
Transmembranei | 459 – 480 | HelicalCuratedAdd BLAST | 22 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000000486 | 22 – 480 | Gamma-aminobutyric acid receptor subunit rho-1Add BLAST | 459 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 141 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 199 ↔ 213 | By similarity | ||
Glycosylationi | 235 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 275 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P56475 |
PRIDEi | P56475 |
ProteomicsDBi | 268854 |
PTM databases
GlyGeni | P56475, 3 sites |
iPTMneti | P56475 |
PhosphoSitePlusi | P56475 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028280, Expressed in retinal neural layer and 45 other tissues |
Genevisiblei | P56475, MM |
Interactioni
Subunit structurei
Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
Interacts with SQSTM1 (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
- protein domain specific binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000029947 |
Miscellaneous databases
RNActi | P56475, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily. [View classification]Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3643, Eukaryota |
GeneTreei | ENSGT00940000158591 |
HOGENOMi | CLU_010920_0_1_1 |
InParanoidi | P56475 |
OMAi | MMMDGSY |
OrthoDBi | 640805at2759 |
PhylomeDBi | P56475 |
TreeFami | TF315453 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR008058, GABAAa_rho1_rcpt IPR008057, GABAAa_rho_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01670, GABAARRHO PR01671, GABAARRHO1 PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P56475-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAVQNMKFG IFLLWWGWVL AAESTAHWPG REVHEPSRKG SRPQRQRRGA
60 70 80 90 100
HDDAHKQGSP ILRRSSDITK SPLTKSEQLL RIDDHDFSMR PGFGGPAIPV
110 120 130 140 150
GVDVQVESLD SISEVDMDFT MTLYLRHYWK DERLSFPSSN NLSMTFDGRL
160 170 180 190 200
VKKIWVPDMF FVHSKRSFIH DTTTDNVMLR VQPDGKVLYS LRVTVTAMCN
210 220 230 240 250
MDFSRFPLDT QTCSLEIESY AYTEDDLMLY WKKGNDSLKT DERISLSQFL
260 270 280 290 300
IQEFHTTTKL AFYSSTGWYN RLYINFTLRR HIFFFLLQTY FPATLMVMLS
310 320 330 340 350
WVSFWIDRRA VPARVPLGIT TVLTMSTIIT GVNASMPRVS YIKAVDIYLW
360 370 380 390 400
VSFVFVFLSV LEYAAVNYLT TVQERKERKL REKISCTCGL PQPRGVMLDS
410 420 430 440 450
SYSDGEVNDL GGYMPENGEK PDRMMVQLTL ASERGSPQRK GQRGSYVSMR
460 470 480
INTHAIDKYS RIIFPAAYIL FNLIYWSIFS
Sequence cautioni
The sequence AAB81964 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM45896 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 414 | M → L in AAB81964 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF024620 mRNA Translation: AAB81964.1 Different initiation. AL670464 Genomic DNA Translation: CAM45896.1 Different initiation. |
CCDSi | CCDS18021.2 |
RefSeqi | NP_032101.3, NM_008075.2 |
Genome annotation databases
Ensembli | ENSMUST00000029947; ENSMUSP00000029947; ENSMUSG00000028280 |
GeneIDi | 14408 |
KEGGi | mmu:14408 |
UCSCi | uc008sfr.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF024620 mRNA Translation: AAB81964.1 Different initiation. AL670464 Genomic DNA Translation: CAM45896.1 Different initiation. |
CCDSi | CCDS18021.2 |
RefSeqi | NP_032101.3, NM_008075.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000029947 |
PTM databases
GlyGeni | P56475, 3 sites |
iPTMneti | P56475 |
PhosphoSitePlusi | P56475 |
Proteomic databases
PaxDbi | P56475 |
PRIDEi | P56475 |
ProteomicsDBi | 268854 |
Protocols and materials databases
Antibodypediai | 31856, 227 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000029947; ENSMUSP00000029947; ENSMUSG00000028280 |
GeneIDi | 14408 |
KEGGi | mmu:14408 |
UCSCi | uc008sfr.2, mouse |
Organism-specific databases
CTDi | 2569 |
MGIi | MGI:95625, Gabrr1 |
Phylogenomic databases
eggNOGi | KOG3643, Eukaryota |
GeneTreei | ENSGT00940000158591 |
HOGENOMi | CLU_010920_0_1_1 |
InParanoidi | P56475 |
OMAi | MMMDGSY |
OrthoDBi | 640805at2759 |
PhylomeDBi | P56475 |
TreeFami | TF315453 |
Enzyme and pathway databases
Reactomei | R-MMU-977443, GABA receptor activation |
Miscellaneous databases
BioGRID-ORCSi | 14408, 1 hit in 50 CRISPR screens |
PROi | PR:P56475 |
RNActi | P56475, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028280, Expressed in retinal neural layer and 45 other tissues |
Genevisiblei | P56475, MM |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR008058, GABAAa_rho1_rcpt IPR008057, GABAAa_rho_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01670, GABAARRHO PR01671, GABAARRHO1 PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GBRR1_MOUSE | |
Accessioni | P56475Primary (citable) accession number: P56475 Secondary accession number(s): A3KG51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 10, 2009 | |
Last modified: | April 7, 2021 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families