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Protein

UvrABC system protein A

Gene

uvrA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 38ATPUniRule annotation8
Zinc fingeri254 – 281C4-typeUniRule annotationAdd BLAST28
Nucleotide bindingi631 – 638ATPUniRule annotation8
Zinc fingeri731 – 757C4-typeUniRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Excision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciHPY:HP0705-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein AUniRule annotation
Short name:
UvrA proteinUniRule annotation
Alternative name(s):
Excinuclease ABC subunit AUniRule annotation
Gene namesi
Name:uvrAUniRule annotation
Ordered Locus Names:HP_0705
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000930541 – 935UvrABC system protein AAdd BLAST935

Proteomic databases

PaxDbiP56474
PRIDEiP56474

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3159N
IntActiP56474, 27 interactors
MINTiP56474
STRINGi85962.HP0705

Structurei

3D structure databases

ProteinModelPortaliP56474
SMRiP56474
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini310 – 579ABC transporter 1UniRule annotationAdd BLAST270
Domaini599 – 931ABC transporter 2UniRule annotationAdd BLAST333

Sequence similaritiesi

Belongs to the ABC transporter superfamily. UvrA family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 281C4-typeUniRule annotationAdd BLAST28
Zinc fingeri731 – 757C4-typeUniRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG4105C5U Bacteria
COG0178 LUCA
KOiK03701
OMAiVIEMNFL

Family and domain databases

HAMAPiMF_00205 UvrA, 1 hit
InterProiView protein in InterPro
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR004602 UvrA
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00630 uvra, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P56474-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKIIIQGAR ENNLKNIFLE IPKNQFVVFT GLSGSGKSTL AFDTLYAEGQ
60 70 80 90 100
RRYLESLSSY ARQFLDKVGK PNVDKIEGLT PAIAIDQKTT SKNPRSTVGT
110 120 130 140 150
ITEIYDYLRL LFARVGEQFC PTCLEPISSM STSDIISQIC HLEENSKIII
160 170 180 190 200
LAPIIKDKKG SFNDKLESLR LKGYVRAFVD GVMVRLDEEI HLHKTKKHTI
210 220 230 240 250
EAVVDRVVVN NENASRIASA IEKALKESYG ELEVEILQDN APSIRKHYSE
260 270 280 290 300
HKACFKCKMS FEELEPLSFS FNSPKGACES CLGLGTKFSL DISKILDPNT
310 320 330 340 350
PLNQGAIKVI FGYNRSYYAQ MFEGFCEYNG IDSALCFNEL NKEQQDALLY
360 370 380 390 400
GNGTEISFHF KNSPLKRPWK GIIQIAYDMF KEQKDLSDYM SEKTCSSCEG
410 420 430 440 450
HRLKASSLSV QVAGLKMADF LTKPIEEVYH FFNDPTHFSY LNEQEKKIAE
460 470 480 490 500
PILKEILERV FFLYDVGLGY LTLGRDARTI SGGESQRIRI ASQIGSGLTG
510 520 530 540 550
VLYVLDEPSI GLHEKDTLKL INTLRNLQKK GNTLIVVEHD KETIKHADFV
560 570 580 590 600
VDIGPKAGRH GGEVVFSGSV KELLQNNHST ALYLNGTKKI ERPKFELPKE
610 620 630 640 650
KHFLEIKNVN INNIKNLSVQ IPLKQLVCIT GVSGSGKSSL ILQTLLPTAQ
660 670 680 690 700
TLLNHAKKTQ SLNGVEIVGL EHLDKVIYLD QAPIGKTPRS NPATYTGVMD
710 720 730 740 750
EIRILFAEQK EAKILGYSAS RFSFNVKGGR CEKCQGDGDI KIEMHFLPDV
760 770 780 790 800
LVQCDSCKGA KYNPQTLEIK VKGKSIADVL NMSVEEAYEF FAKFPKIAVK
810 820 830 840 850
LKTLMDVGLG YITLGQNATT LSGGEAQRIK LAKELSKKDT GKTLYILDEP
860 870 880 890 900
TTGLHFEDVN HLLQVLHSLV ALGNSMLVIE HNLDIIKNAD YIIDMGPDGG
910 920 930
DKGGKVIASG TPLEVAQNCE KTQSYTGKFL ALELK
Length:935
Mass (Da):104,061
Last modified:July 15, 1998 - v1
Checksum:i6ACF1A675999E141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07755.1
PIRiA64608
RefSeqiNP_207499.1, NC_000915.1
WP_010875529.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD07755; AAD07755; HP_0705
GeneIDi899317
KEGGihpy:HP0705
PATRICifig|85962.8.peg.736

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07755.1
PIRiA64608
RefSeqiNP_207499.1, NC_000915.1
WP_010875529.1, NC_018939.1

3D structure databases

ProteinModelPortaliP56474
SMRiP56474
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3159N
IntActiP56474, 27 interactors
MINTiP56474
STRINGi85962.HP0705

Proteomic databases

PaxDbiP56474
PRIDEiP56474

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07755; AAD07755; HP_0705
GeneIDi899317
KEGGihpy:HP0705
PATRICifig|85962.8.peg.736

Phylogenomic databases

eggNOGiENOG4105C5U Bacteria
COG0178 LUCA
KOiK03701
OMAiVIEMNFL

Enzyme and pathway databases

BioCyciHPY:HP0705-MONOMER

Family and domain databases

HAMAPiMF_00205 UvrA, 1 hit
InterProiView protein in InterPro
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR004602 UvrA
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00630 uvra, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUVRA_HELPY
AccessioniPrimary (citable) accession number: P56474
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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