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Protein

Agouti-related protein

Gene

Agrp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity (By similarity). It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Agouti-related protein
Gene namesi
Name:Agrp
Synonyms:Agrt, Art
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:892013 Agrp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000043404521 – 81By similarityAdd BLAST61
ChainiPRO_000000103582 – 131Agouti-related proteinAdd BLAST50

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi86 ↔ 101PROSITE-ProRule annotationBy similarity
Disulfide bondi93 ↔ 107PROSITE-ProRule annotationBy similarity
Disulfide bondi100 ↔ 118PROSITE-ProRule annotationBy similarity
Disulfide bondi104 ↔ 128PROSITE-ProRule annotationBy similarity
Disulfide bondi109 ↔ 116PROSITE-ProRule annotationBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei81 – 82Cleavage; by PCSK1By similarity2

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP56473
PRIDEiP56473

Expressioni

Tissue specificityi

Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung.

Inductioni

Hypothalamic expression is elevated circa 10-fold in ob/ob and db/db mice.

Gene expression databases

BgeeiENSMUSG00000005705
CleanExiMM_AGRP
ExpressionAtlasiP56473 baseline and differential
GenevisibleiP56473 MM

Interactioni

Subunit structurei

Interacts with melanocortin receptors MC3R, MC4R and MC5R.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005849

Structurei

3D structure databases

ProteinModelPortaliP56473
SMRiP56473
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 128AgoutiPROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 112Interaction with melanocortin receptorsBy similarity3

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Keywords - Domaini

Knottin, Signal

Phylogenomic databases

eggNOGiENOG410J14P Eukaryota
ENOG410Z66T LUCA
GeneTreeiENSGT00510000048590
HOGENOMiHOG000033861
HOVERGENiHBG050467
InParanoidiP56473
KOiK05231
OMAiGHQVPCC
OrthoDBiEOG091G1506
PhylomeDBiP56473
TreeFamiTF330729

Family and domain databases

Gene3Di4.10.760.10, 1 hit
InterProiView protein in InterPro
IPR007733 Agouti
IPR027300 Agouti_dom
IPR036836 Agouti_dom_sf
PANTHERiPTHR16551 PTHR16551, 1 hit
PfamiView protein in Pfam
PF05039 Agouti, 1 hit
SMARTiView protein in SMART
SM00792 Agouti, 1 hit
SUPFAMiSSF57055 SSF57055, 1 hit
PROSITEiView protein in PROSITE
PS60024 AGOUTI_1, 1 hit
PS51150 AGOUTI_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTAMLLSCV LLLALPPTLG VQMGVAPLKG IRRPDQALFP EFPGLSLNGL
60 70 80 90 100
KKTTADRAEE VLLQKAEALA EVLDPQNRES RSPRRCVRLH ESCLGQQVPC
110 120 130
CDPCATCYCR FFNAFCYCRK LGTATNLCSR T
Length:131
Mass (Da):14,432
Last modified:July 15, 1998 - v1
Checksum:i25D9766D074C6834
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89484 mRNA Translation: AAB68620.1
U89486 Genomic DNA Translation: AAB68622.1
BC079902 mRNA Translation: AAH79902.1
CCDSiCCDS22605.1
RefSeqiNP_001258735.1, NM_001271806.1
NP_031453.1, NM_007427.3
UniGeneiMm.441696
Mm.491630

Genome annotation databases

EnsembliENSMUST00000005849; ENSMUSP00000005849; ENSMUSG00000005705
ENSMUST00000194091; ENSMUSP00000142044; ENSMUSG00000005705
GeneIDi11604
KEGGimmu:11604
UCSCiuc009ndh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAGRP_MOUSE
AccessioniPrimary (citable) accession number: P56473
Secondary accession number(s): O35967
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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