UniProtKB - P56470 (LEG4_HUMAN)
Protein
Galectin-4
Gene
LGALS4
Organism
Homo sapiens (Human)
Status
Functioni
Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
GO - Molecular functioni
- carbohydrate binding Source: ProtInc
- galactoside binding Source: Ensembl
GO - Biological processi
- cell adhesion Source: ProtInc
Keywordsi
Ligand | Lectin |
Enzyme and pathway databases
PathwayCommonsi | P56470 |
Protein family/group databases
UniLectini | P56470 |
Names & Taxonomyi
Protein namesi | Recommended name: Galectin-4Short name: Gal-4 Alternative name(s): Antigen NY-CO-27 L-36 lactose-binding protein Short name: L36LBP Lactose-binding lectin 4 |
Gene namesi | Name:LGALS4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6565, LGALS4 |
MIMi | 602518, gene |
neXtProti | NX_P56470 |
VEuPathDBi | HostDB:ENSG00000171747.8 |
Subcellular locationi
Cytosol
- cytosol Source: ProtInc
Extracellular region or secreted
- extracellular space Source: Ensembl
Plasma Membrane
- plasma membrane Source: ProtInc
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 3960 |
OpenTargetsi | ENSG00000171747 |
PharmGKBi | PA30342 |
Miscellaneous databases
Pharosi | P56470, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1671608 |
Genetic variation databases
BioMutai | LGALS4 |
DMDMi | 3024079 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076934 | 1 – 323 | Galectin-4Add BLAST | 323 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 258 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P56470 |
MassIVEi | P56470 |
PaxDbi | P56470 |
PeptideAtlasi | P56470 |
PRIDEi | P56470 |
ProteomicsDBi | 56919 |
PTM databases
iPTMneti | P56470 |
PhosphoSitePlusi | P56470 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171747, Expressed in mucosa of transverse colon and 127 other tissues |
ExpressionAtlasi | P56470, baseline and differential |
Genevisiblei | P56470, HS |
Organism-specific databases
HPAi | ENSG00000171747, Group enriched (gallbladder, intestine, lymphoid tissue) |
Interactioni
Subunit structurei
Monomer.
By similarityBinary interactionsi
Hide detailsP56470
Protein-protein interaction databases
BioGRIDi | 110151, 17 interactors |
IntActi | P56470, 16 interactors |
STRINGi | 9606.ENSP00000302100 |
Chemistry databases
BindingDBi | P56470 |
Miscellaneous databases
RNActi | P56470, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P56470 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P56470 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 150 | Galectin 1PROSITE-ProRule annotationAdd BLAST | 132 | |
Domaini | 194 – 323 | Galectin 2PROSITE-ProRule annotationAdd BLAST | 130 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 256 – 262 | Beta-galactoside bindingBy similarity | 7 |
Domaini
Contains two homologous but distinct carbohydrate-binding domains.
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3587, Eukaryota |
GeneTreei | ENSGT00940000160378 |
HOGENOMi | CLU_037794_1_0_1 |
InParanoidi | P56470 |
OMAi | NPPVPYF |
OrthoDBi | 829777at2759 |
PhylomeDBi | P56470 |
TreeFami | TF315551 |
Family and domain databases
CDDi | cd00070, GLECT, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR044156, Galectin-like IPR015533, Galectin4/6 IPR001079, Galectin_CRD |
PANTHERi | PTHR11346, PTHR11346, 1 hit PTHR11346:SF32, PTHR11346:SF32, 1 hit |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 2 hits |
SMARTi | View protein in SMART SM00908, Gal-bind_lectin, 2 hits SM00276, GLECT, 2 hits |
SUPFAMi | SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P56470-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAYVPAPGYQ PTYNPTLPYY QPIPGGLNVG MSVYIQGVAS EHMKRFFVNF
60 70 80 90 100
VVGQDPGSDV AFHFNPRFDG WDKVVFNTLQ GGKWGSEERK RSMPFKKGAA
110 120 130 140 150
FELVFIVLAE HYKVVVNGNP FYEYGHRLPL QMVTHLQVDG DLQLQSINFI
160 170 180 190 200
GGQPLRPQGP PMMPPYPGPG HCHQQLNSLP TMEGPPTFNP PVPYFGRLQG
210 220 230 240 250
GLTARRTIII KGYVPPTGKS FAINFKVGSS GDIALHINPR MGNGTVVRNS
260 270 280 290 300
LLNGSWGSEE KKITHNPFGP GQFFDLSIRC GLDRFKVYAN GQHLFDFAHR
310 320
LSAFQRVDTL EIQGDVTLSY VQI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QZ93 | M0QZ93_HUMAN | Galectin | LGALS4 | 218 | Annotation score: | ||
M0R349 | M0R349_HUMAN | Galectin-4 | LGALS4 | 31 | Annotation score: | ||
M0R1B2 | M0R1B2_HUMAN | Galectin-4 | LGALS4 | 38 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049769 | 16 | T → M. Corresponds to variant dbSNP:rs8106404EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006781 mRNA Translation: BAA22165.1 AF014838 mRNA Translation: AAC51763.1 U82953 mRNA Translation: AAB86590.1 BC003661 mRNA Translation: AAH03661.1 BC005146 mRNA Translation: AAH05146.1 BC034750 mRNA Translation: AAH34750.1 |
CCDSi | CCDS12521.1 |
RefSeqi | NP_006140.1, NM_006149.3 |
Genome annotation databases
Ensembli | ENST00000307751; ENSP00000302100; ENSG00000171747 ENST00000634573; ENSP00000489411; ENSG00000282992 |
GeneIDi | 3960 |
KEGGi | hsa:3960 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding Galectin-4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006781 mRNA Translation: BAA22165.1 AF014838 mRNA Translation: AAC51763.1 U82953 mRNA Translation: AAB86590.1 BC003661 mRNA Translation: AAH03661.1 BC005146 mRNA Translation: AAH05146.1 BC034750 mRNA Translation: AAH34750.1 |
CCDSi | CCDS12521.1 |
RefSeqi | NP_006140.1, NM_006149.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1X50 | NMR | - | A | 173-323 | [»] | |
4XZP | X-ray | 1.48 | A | 1-152 | [»] | |
4YLZ | X-ray | 2.10 | A/B/C/D | 171-323 | [»] | |
4YM0 | X-ray | 2.30 | A/B/C/D | 171-323 | [»] | |
4YM1 | X-ray | 2.00 | A/B/C/D | 171-323 | [»] | |
4YM2 | X-ray | 2.10 | A/B/C/D | 171-323 | [»] | |
4YM3 | X-ray | 1.89 | A/B/C/D | 171-323 | [»] | |
5CBL | X-ray | 1.78 | A/B/C/D | 179-323 | [»] | |
5DUU | X-ray | 2.00 | A/B/C/D | 1-155 | [»] | |
5DUV | X-ray | 1.90 | A/B/C/D | 1-155 | [»] | |
5DUW | X-ray | 1.70 | A/B/C/D | 1-155 | [»] | |
5DUX | X-ray | 1.85 | A/B/C/D | 1-155 | [»] | |
SMRi | P56470 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110151, 17 interactors |
IntActi | P56470, 16 interactors |
STRINGi | 9606.ENSP00000302100 |
Chemistry databases
BindingDBi | P56470 |
ChEMBLi | CHEMBL1671608 |
Protein family/group databases
UniLectini | P56470 |
PTM databases
iPTMneti | P56470 |
PhosphoSitePlusi | P56470 |
Genetic variation databases
BioMutai | LGALS4 |
DMDMi | 3024079 |
Proteomic databases
jPOSTi | P56470 |
MassIVEi | P56470 |
PaxDbi | P56470 |
PeptideAtlasi | P56470 |
PRIDEi | P56470 |
ProteomicsDBi | 56919 |
Protocols and materials databases
Antibodypediai | 30166, 360 antibodies |
DNASUi | 3960 |
Genome annotation databases
Ensembli | ENST00000307751; ENSP00000302100; ENSG00000171747 ENST00000634573; ENSP00000489411; ENSG00000282992 |
GeneIDi | 3960 |
KEGGi | hsa:3960 |
Organism-specific databases
CTDi | 3960 |
DisGeNETi | 3960 |
GeneCardsi | LGALS4 |
HGNCi | HGNC:6565, LGALS4 |
HPAi | ENSG00000171747, Group enriched (gallbladder, intestine, lymphoid tissue) |
MIMi | 602518, gene |
neXtProti | NX_P56470 |
OpenTargetsi | ENSG00000171747 |
PharmGKBi | PA30342 |
VEuPathDBi | HostDB:ENSG00000171747.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3587, Eukaryota |
GeneTreei | ENSGT00940000160378 |
HOGENOMi | CLU_037794_1_0_1 |
InParanoidi | P56470 |
OMAi | NPPVPYF |
OrthoDBi | 829777at2759 |
PhylomeDBi | P56470 |
TreeFami | TF315551 |
Enzyme and pathway databases
PathwayCommonsi | P56470 |
Miscellaneous databases
BioGRID-ORCSi | 3960, 7 hits in 982 CRISPR screens |
ChiTaRSi | LGALS4, human |
EvolutionaryTracei | P56470 |
GeneWikii | LGALS4 |
GenomeRNAii | 3960 |
Pharosi | P56470, Tchem |
PROi | PR:P56470 |
RNActi | P56470, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171747, Expressed in mucosa of transverse colon and 127 other tissues |
ExpressionAtlasi | P56470, baseline and differential |
Genevisiblei | P56470, HS |
Family and domain databases
CDDi | cd00070, GLECT, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR044156, Galectin-like IPR015533, Galectin4/6 IPR001079, Galectin_CRD |
PANTHERi | PTHR11346, PTHR11346, 1 hit PTHR11346:SF32, PTHR11346:SF32, 1 hit |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 2 hits |
SMARTi | View protein in SMART SM00908, Gal-bind_lectin, 2 hits SM00276, GLECT, 2 hits |
SUPFAMi | SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LEG4_HUMAN | |
Accessioni | P56470Primary (citable) accession number: P56470 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | April 7, 2021 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references