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Protein

Galectin-4

Gene

LGALS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • galactoside binding Source: Ensembl

GO - Biological processi

  • cell adhesion Source: ProtInc

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-4
Short name:
Gal-4
Alternative name(s):
Antigen NY-CO-27
L-36 lactose-binding protein
Short name:
L36LBP
Lactose-binding lectin 4
Gene namesi
Name:LGALS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171747.8
HGNCiHGNC:6565 LGALS4
MIMi602518 gene
neXtProtiNX_P56470

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi3960
OpenTargetsiENSG00000171747
PharmGKBiPA30342

Chemistry databases

ChEMBLiCHEMBL1671608

Polymorphism and mutation databases

BioMutaiLGALS4
DMDMi3024079

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769341 – 323Galectin-4Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP56470
PeptideAtlasiP56470
PRIDEiP56470
ProteomicsDBi56919

PTM databases

iPTMnetiP56470
PhosphoSitePlusiP56470

Expressioni

Gene expression databases

BgeeiENSG00000171747
CleanExiHS_LGALS4
ExpressionAtlasiP56470 baseline and differential
GenevisibleiP56470 HS

Organism-specific databases

HPAiCAB025653
HPA031184
HPA031185
HPA031186

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi110151, 4 interactors
IntActiP56470, 18 interactors
STRINGi9606.ENSP00000302100

Chemistry databases

BindingDBiP56470

Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 14Combined sources3
Beta strandi17 – 22Combined sources6
Beta strandi32 – 38Combined sources7
Beta strandi46 – 55Combined sources10
Beta strandi60 – 67Combined sources8
Beta strandi69 – 71Combined sources3
Beta strandi73 – 80Combined sources8
Beta strandi88 – 91Combined sources4
Beta strandi100 – 107Combined sources8
Beta strandi109 – 116Combined sources8
Beta strandi119 – 125Combined sources7
Helixi130 – 132Combined sources3
Beta strandi135 – 150Combined sources16
Beta strandi187 – 189Combined sources3
Beta strandi192 – 197Combined sources6
Beta strandi206 – 213Combined sources8
Beta strandi220 – 226Combined sources7
Turni228 – 230Combined sources3
Beta strandi233 – 240Combined sources8
Turni241 – 244Combined sources4
Beta strandi245 – 251Combined sources7
Beta strandi273 – 280Combined sources8
Beta strandi282 – 289Combined sources8
Beta strandi292 – 298Combined sources7
Beta strandi300 – 302Combined sources3
Helixi304 – 306Combined sources3
Beta strandi309 – 315Combined sources7
Beta strandi317 – 322Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X50NMR-A173-323[»]
4XZPX-ray1.48A1-152[»]
4YLZX-ray2.10A/B/C/D171-323[»]
4YM0X-ray2.30A/B/C/D171-323[»]
4YM1X-ray2.00A/B/C/D171-323[»]
4YM2X-ray2.10A/B/C/D171-323[»]
4YM3X-ray1.89A/B/C/D171-323[»]
5CBLX-ray1.78A/B/C/D179-323[»]
5DUUX-ray2.00A/B/C/D1-155[»]
5DUVX-ray1.90A/B/C/D1-155[»]
5DUWX-ray1.70A/B/C/D1-155[»]
5DUXX-ray1.85A/B/C/D1-155[»]
ProteinModelPortaliP56470
SMRiP56470
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56470

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 150Galectin 1PROSITE-ProRule annotationAdd BLAST132
Domaini194 – 323Galectin 2PROSITE-ProRule annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni256 – 262Beta-galactoside bindingBy similarity7

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00760000119105
HOGENOMiHOG000290194
HOVERGENiHBG002412
InParanoidiP56470
KOiK10091
OMAiGPPVFNP
OrthoDBiEOG091G0WP8
PhylomeDBiP56470
TreeFamiTF315551

Family and domain databases

CDDicd00070 GLECT, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR015533 Galectin4/6
IPR001079 Galectin_CRD
PANTHERiPTHR11346:SF32 PTHR11346:SF32, 1 hit
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 2 hits
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 2 hits
SM00276 GLECT, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 2 hits

Sequencei

Sequence statusi: Complete.

P56470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYVPAPGYQ PTYNPTLPYY QPIPGGLNVG MSVYIQGVAS EHMKRFFVNF
60 70 80 90 100
VVGQDPGSDV AFHFNPRFDG WDKVVFNTLQ GGKWGSEERK RSMPFKKGAA
110 120 130 140 150
FELVFIVLAE HYKVVVNGNP FYEYGHRLPL QMVTHLQVDG DLQLQSINFI
160 170 180 190 200
GGQPLRPQGP PMMPPYPGPG HCHQQLNSLP TMEGPPTFNP PVPYFGRLQG
210 220 230 240 250
GLTARRTIII KGYVPPTGKS FAINFKVGSS GDIALHINPR MGNGTVVRNS
260 270 280 290 300
LLNGSWGSEE KKITHNPFGP GQFFDLSIRC GLDRFKVYAN GQHLFDFAHR
310 320
LSAFQRVDTL EIQGDVTLSY VQI
Length:323
Mass (Da):35,941
Last modified:July 15, 1998 - v1
Checksum:iE79EC0A9AB3990EF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04976916T → M. Corresponds to variant dbSNP:rs8106404Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006781 mRNA Translation: BAA22165.1
AF014838 mRNA Translation: AAC51763.1
U82953 mRNA Translation: AAB86590.1
BC003661 mRNA Translation: AAH03661.1
BC005146 mRNA Translation: AAH05146.1
BC034750 mRNA Translation: AAH34750.1
CCDSiCCDS12521.1
RefSeqiNP_006140.1, NM_006149.3
UniGeneiHs.5302

Genome annotation databases

EnsembliENST00000307751; ENSP00000302100; ENSG00000171747
ENST00000634573; ENSP00000489411; ENSG00000282992
GeneIDi3960
KEGGihsa:3960

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLEG4_HUMAN
AccessioniPrimary (citable) accession number: P56470
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: June 20, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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