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Protein

Transcription termination factor Rho

Gene

rho

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei231ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 193ATPUniRule annotation6
Nucleotide bindingi200 – 205ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processTranscription, Transcription regulation, Transcription termination
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP0550-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
ATP-dependent helicase RhoUniRule annotation
Gene namesi
Name:rhoUniRule annotation
Ordered Locus Names:HP_0550
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001889661 – 438Transcription termination factor RhoAdd BLAST438

Proteomic databases

PaxDbiP56466
PRIDEiP56466

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3446N
IntActiP56466, 4 interactors
MINTiP56466
STRINGi85962.HP0550

Structurei

3D structure databases

ProteinModelPortaliP56466
SMRiP56466
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 145Rho RNA-BDPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the Rho family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4P Bacteria
COG1158 LUCA
KOiK03628
OMAiDYNYLPG

Family and domain databases

CDDicd04459 Rho_CSD, 1 hit
HAMAPiMF_01884 Rho, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR011129 CSD
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
IPR011112 Rho_N
IPR036269 Rho_N_sf
IPR011113 Rho_RNA-bd
IPR004665 Term_rho
PANTHERiPTHR15184:SF34 PTHR15184:SF34, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF07498 Rho_N, 1 hit
PF07497 Rho_RNA_bind, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00357 CSP, 1 hit
SM00959 Rho_N, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 1 hit
SSF68912 SSF68912, 1 hit
TIGRFAMsiTIGR00767 rho, 1 hit
PROSITEiView protein in PROSITE
PS51856 RHO_RNA_BD, 1 hit

Sequencei

Sequence statusi: Complete.

P56466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNENAPTHKS SHKVKTHTPV SGYHIEDLRT YPTEKLLEIA NKLKVENPQE
60 70 80 90 100
FKRQDLMFEI LKTQVTQGGY ILFTGILEIM PDGYGFLRGF DGSFSDGHND
110 120 130 140 150
TYVSPSQIRR FALRNGDIVT GQVRSPKDQE KYYALLKIEA INYSPSDEIR
160 170 180 190 200
NRPLFDNLTP LFPDEQIKLE YEPTKVTGRM LDLFSPVGKG QRALIVAPPR
210 220 230 240 250
TGKTELMKEL AQGITSNHPE VELIILLVDE RPEEVTDMQR SVKGQVFSST
260 270 280 290 300
FDLPANNHIR IAELVLERAK RRVEMGKDVV VLLDSITRLA RAYNAVTPSS
310 320 330 340 350
GKVLSGGVDA NALHRPKRFF GAARNIEEGG SLTIIATALI ETGSRMDEVI
360 370 380 390 400
FEEFKGTGNS EIVLARNIAD RRIYPAFDIL KSGTRKDNIL LGKDRLTKVW
410 420 430
VLRNVMQQMD DIEALSFVYS KMQQTKDNEE FLNLMNEK
Length:438
Mass (Da):49,547
Last modified:July 15, 1998 - v1
Checksum:iD4D06E6CD1E300F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07616.1
PIRiF64588
RefSeqiNP_207345.1, NC_000915.1
WP_001004715.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD07616; AAD07616; HP_0550
GeneIDi898947
KEGGiheo:C694_02845
hpy:HP0550
PATRICifig|85962.47.peg.595

Similar proteinsi

Entry informationi

Entry nameiRHO_HELPY
AccessioniPrimary (citable) accession number: P56466
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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