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Entry version 118 (12 Aug 2020)
Sequence version 1 (15 Jul 1998)
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Protein

UvrABC system protein C

Gene

uvrC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
HPY:HP0821-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:HP_0821
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85962 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000429 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001383051 – 594UvrABC system protein CAdd BLAST594

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56428

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UvrB in an incision complex.

UniRule annotation

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P56428
With#Exp.IntAct
itself3EBI-7556231,EBI-7556231

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-3436N

Protein interaction database and analysis system

More...
IntActi
P56428, 12 interactors

Molecular INTeraction database

More...
MINTi
P56428

STRING: functional protein association networks

More...
STRINGi
85962.C694_04205

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P56428

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 99GIY-YIGUniRule annotationAdd BLAST87
Domaini205 – 240UVRUniRule annotationAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0322, Bacteria

KEGG Orthology (KO)

More...
KOi
K03703

Identification of Orthologs from Complete Genome Data

More...
OMAi
LFPIRQC

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.340, 1 hit
3.40.1440.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00203, UvrC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000305, GIY-YIG_endonuc
IPR035901, GIY-YIG_endonuc_sf
IPR010994, RuvA_2-like
IPR001943, UVR_dom
IPR036876, UVR_dom_sf
IPR004791, UvrC
IPR001162, UvrC_homol_region
IPR038476, UvrC_homol_region_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01541, GIY-YIG, 1 hit
PF02151, UVR, 1 hit
PF08459, UvrC_HhH_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00465, GIYc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46600, SSF46600, 1 hit
SSF47781, SSF47781, 1 hit
SSF82771, SSF82771, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00194, uvrC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50164, GIY_YIG, 1 hit
PS50151, UVR, 1 hit
PS50165, UVRC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P56428-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADLLSSLKN LPNSSGVYQY FDKNRQLLYI GKAKNLKKRI KSYFSIRNNE
60 70 80 90 100
ITPNHRASLR IQMMVKQIAF LETILVENEQ DALILENSLI KQLKPKYNIL
110 120 130 140 150
LRDDKTYPYI YMDFSTDFPI PLITRKILKQ PGVKYFGPFT SGAKDILDSL
160 170 180 190 200
YELLPLVQKK NCIKDKKACI FYQIERCKAP CENKITKEEY LKIAKECLEM
210 220 230 240 250
IENKDRLIKE LELKMERLSN NLRFEEALIY RDRIAKIQKI APFTCMDLAK
260 270 280 290 300
LYDLDIFAFY GASNKAVLVK MFMRGGKIIS SAFEKIHSLN GFDTDEAMKQ
310 320 330 340 350
AIINHYQSHL PLMPEQILLN ACSNETLKEL QEFISHQYSK KIALSIPKKG
360 370 380 390 400
DKLALIEIAM KNAQEIFSQE KTSNEDLILE EARSLFKLEC MPYRVEIFDT
410 420 430 440 450
SHHSSSQCVG GMVVYENNAF QKNSYRRYHL KGSDEYTQMS ELLTRRALDF
460 470 480 490 500
AKEPPPNLWV IDGGRAQLNI ALEILKSSGS FVEVIAISKE KRDSKAYRSK
510 520 530 540 550
GGAKDIIHTP SDTFKLLPSD KRLQWVQKLR DESHRYAINF HRSTKLKNMK
560 570 580 590
QIALLKEKGI GEASVKKLLD YFGSFEAIEK ASEQEKNAVL KKRI
Length:594
Mass (Da):68,680
Last modified:July 15, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2550E9FE4A5FBAC6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07868.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E64622

NCBI Reference Sequences

More...
RefSeqi
NP_207614.1, NC_000915.1
WP_000774319.1, NC_018939.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD07868; AAD07868; HP_0821

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
heo:C694_04205
hpy:HP0821

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|85962.47.peg.875

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07868.1
PIRiE64622
RefSeqiNP_207614.1, NC_000915.1
WP_000774319.1, NC_018939.1

3D structure databases

SMRiP56428
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-3436N
IntActiP56428, 12 interactors
MINTiP56428
STRINGi85962.C694_04205

Proteomic databases

PaxDbiP56428

Genome annotation databases

EnsemblBacteriaiAAD07868; AAD07868; HP_0821
KEGGiheo:C694_04205
hpy:HP0821
PATRICifig|85962.47.peg.875

Phylogenomic databases

eggNOGiCOG0322, Bacteria
KOiK03703
OMAiLFPIRQC

Enzyme and pathway databases

BioCyciHPY:HP0821-MONOMER

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203, UvrC, 1 hit
InterProiView protein in InterPro
IPR000305, GIY-YIG_endonuc
IPR035901, GIY-YIG_endonuc_sf
IPR010994, RuvA_2-like
IPR001943, UVR_dom
IPR036876, UVR_dom_sf
IPR004791, UvrC
IPR001162, UvrC_homol_region
IPR038476, UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541, GIY-YIG, 1 hit
PF02151, UVR, 1 hit
PF08459, UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465, GIYc, 1 hit
SUPFAMiSSF46600, SSF46600, 1 hit
SSF47781, SSF47781, 1 hit
SSF82771, SSF82771, 1 hit
TIGRFAMsiTIGR00194, uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164, GIY_YIG, 1 hit
PS50151, UVR, 1 hit
PS50165, UVRC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUVRC_HELPY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56428
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: August 12, 2020
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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