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Protein

Molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei31GTPUniRule annotation1
Metal bindingi104MagnesiumUniRule annotation1
Binding sitei104GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 16GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP0769-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:HP_0769
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001348921 – 201Molybdenum cofactor guanylyltransferaseAdd BLAST201

Proteomic databases

PaxDbiP56415.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3751N.
IntActiP56415. 2 interactors.
MINTiP56415.
STRINGi85962.HP0769.

Structurei

3D structure databases

ProteinModelPortaliP56415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41080AZ. Bacteria.
COG0746. LUCA.
KOiK03752.
OMAiHYLISLW.

Family and domain databases

CDDicd02503. MobA. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA. 1 hit.
InterProiView protein in InterPro
IPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF12804. NTP_transf_3. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

P56415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNPIIDNIP CVLLAGGKSS RFITNNIQTN KALMPLKSYS SLLEYQYTRL
60 70 80 90 100
LKLFKKVIIS TKKSYELNAP YLLEKESDLF SPLFGIHNAF LTLQTPYIFF
110 120 130 140 150
IPIDTPLVSF ESIKALCGIK NFSVTYAKSP TKEHYLISLW HQNTLNALIY
160 170 180 190 200
ALKTQNYRLS DLVKNTSSVA INFDKEEEFL NLNTLKDYEL AVQILKKRAN

G
Length:201
Mass (Da):23,011
Last modified:July 15, 1998 - v1
Checksum:i4C0E81822AB5DAAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07818.1.
PIRiA64616.
RefSeqiNP_207562.1. NC_000915.1.
WP_000795288.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07818; AAD07818; HP_0769.
GeneIDi898916.
KEGGiheo:C694_03950.
hpy:HP0769.
PATRICifig|85962.47.peg.821.

Similar proteinsi

Entry informationi

Entry nameiMOBA_HELPY
AccessioniPrimary (citable) accession number: P56415
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: February 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome