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UniProtKB - P56410 (TRFE_ANAPL)
Protein
Ovotransferrin
Gene
N/A
Organism
Anas platyrhynchos (Mallard) (Anas boschas)
Status
Functioni
Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
Ovotransferrin has a bacteriostatic function. Its concentration in avian egg is the highest concentration of any transferrin in vivo (By similarity).
By similarityGO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- ion transport Source: UniProtKB-KW
- iron ion homeostasis Source: UniProtKB-KW
Keywordsi
Biological process | Ion transport, Iron transport, Transport |
Ligand | Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Ovotransferrin |
Organismi | Anas platyrhynchos (Mallard) (Anas boschas) |
Taxonomic identifieri | 8839 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Anseriformes › Anatidae › Anatinae › Anas |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: InterPro
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082440 | 1 – 686 | OvotransferrinAdd BLAST | 686 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 10 ↔ 45 | |||
Disulfide bondi | 20 ↔ 36 | |||
Disulfide bondi | 115 ↔ 197 | |||
Disulfide bondi | 160 ↔ 174 | |||
Disulfide bondi | 171 ↔ 182 | |||
Disulfide bondi | 228 ↔ 242 | |||
Disulfide bondi | 348 ↔ 380 | |||
Disulfide bondi | 358 ↔ 371 | |||
Disulfide bondi | 405 ↔ 680 | |||
Disulfide bondi | 421 ↔ 643 | |||
Disulfide bondi | 454 ↔ 530 | |||
Glycosylationi | 473 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 478 ↔ 671 | |||
Disulfide bondi | 488 ↔ 502 | |||
Disulfide bondi | 499 ↔ 513 | |||
Glycosylationi | 548 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 570 ↔ 584 |
Keywords - PTMi
Disulfide bond, GlycoproteinInteractioni
Subunit structurei
Monomer.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
PCDDBi | P56410 |
SMRi | P56410 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P56410 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 333 | Transferrin-like 1PROSITE-ProRule annotationAdd BLAST | 327 | |
Domaini | 345 – 670 | Transferrin-like 2PROSITE-ProRule annotationAdd BLAST | 326 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 333 – 341 | Connecting region | 9 |
Sequence similaritiesi
Belongs to the transferrin family.PROSITE-ProRule annotation
Keywords - Domaini
RepeatPhylogenomic databases
OMAi | KWCAIGH |
Family and domain databases
InterProi | View protein in InterPro IPR016357, Transferrin IPR001156, Transferrin-like_dom IPR018195, Transferrin_Fe_BS |
Pfami | View protein in Pfam PF00405, Transferrin, 2 hits |
PIRSFi | PIRSF002549, Transferrin, 1 hit |
PRINTSi | PR00422, TRANSFERRIN |
SMARTi | View protein in SMART SM00094, TR_FER, 2 hits |
PROSITEi | View protein in PROSITE PS00205, TRANSFERRIN_LIKE_1, 2 hits PS00206, TRANSFERRIN_LIKE_2, 2 hits PS00207, TRANSFERRIN_LIKE_3, 1 hit PS51408, TRANSFERRIN_LIKE_4, 2 hits |
i Sequence
Sequence statusi: Complete.
P56410-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
APPKTTVRWC TISSAEEKKC NSLKDHMQQE RVTLSCVQKA TYLDCIKAIS
60 70 80 90 100
NNEADAISLD GGQVFEAGLA PYKLKPIAAE VYERSGGSTT SYYAVAVVKK
110 120 130 140 150
GTDFMIKDLR GKTSCHTGLG RSAGWNIPIG TLIHREDIEW EGIESGISEQ
160 170 180 190 200
AVAKFFSASC VPGATIEQKL CRQCKGDAKT KCLRNGPYSG YSGAFQCLKD
210 220 230 240 250
GKGDVAFVKH TTVQENAPEE KDEYELLCLD GSRQPVDSYK TCNWARVAAH
260 270 280 290 300
AVVARDDSKI DDIWSFLGMQ AYSLGVDTTS DFHLFGPPGK KDPVLKDLLF
310 320 330 340 350
KDSAIMLKRV PELMDSQLYL GFEYYSAIQS LRKDQLTVGP RENKIQWCAV
360 370 380 390 400
GKDEKSKCDR WSVVSNGEVE CTILDDNKDC IVKITKGEAD AISLDGGFVY
410 420 430 440 450
TAGVCGLVPV VGESYEDETQ CSKDEEQPAY YFAVAVVKKS SAITWNNLQG
460 470 480 490 500
KKSCHTAVGR TAGWNIPMGL IHNKTGSCDF DDYFSEGCAP GSPPNSRLCK
510 520 530 540 550
LCQGSGENLL EKCVASSHEK YYGYTGALRC LVEQGDVAFI KHSTVGENVS
560 570 580 590 600
GSNKDDWAKG LTRDDFELLC TNGKRAKTMD YKTCHLAKVP THAVVARPEK
610 620 630 640 650
ANKIRELLEG QEKLFGLHGT EKERFMMFQS QTKDLLFKAL TKCLVKLRQG
660 670 680
ITYKEFLGDE YYASVASLNT CNPSDLLQVC TFLEDK
Similar proteinsi
Cross-referencesi
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AOV | X-ray | 4.00 | A | 1-686 | [»] | |
1DOT | X-ray | 2.35 | A | 1-686 | [»] | |
1GV8 | X-ray | 1.95 | A | 91-249 | [»] | |
1GVC | X-ray | 1.90 | A | 91-247 | [»] | |
1OVB | X-ray | 2.30 | A | 91-249 | [»] | |
PCDDBi | P56410 | |||||
SMRi | P56410 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
Allergomei | 2104, Ana p 3 |
Phylogenomic databases
OMAi | KWCAIGH |
Miscellaneous databases
EvolutionaryTracei | P56410 |
Family and domain databases
InterProi | View protein in InterPro IPR016357, Transferrin IPR001156, Transferrin-like_dom IPR018195, Transferrin_Fe_BS |
Pfami | View protein in Pfam PF00405, Transferrin, 2 hits |
PIRSFi | PIRSF002549, Transferrin, 1 hit |
PRINTSi | PR00422, TRANSFERRIN |
SMARTi | View protein in SMART SM00094, TR_FER, 2 hits |
PROSITEi | View protein in PROSITE PS00205, TRANSFERRIN_LIKE_1, 2 hits PS00206, TRANSFERRIN_LIKE_2, 2 hits PS00207, TRANSFERRIN_LIKE_3, 1 hit PS51408, TRANSFERRIN_LIKE_4, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TRFE_ANAPL | |
Accessioni | P56410Primary (citable) accession number: P56410 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | September 29, 2021 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families