Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aquaporin-8

Gene

Aqp8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel; mercury-sensitive. Also permeable to urea but not to glycerol.

GO - Molecular functioni

GO - Biological processi

  • canalicular bile acid transport Source: MGI
  • cellular response to cAMP Source: Ensembl
  • water transport Source: MGI

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-432047 Passive transport by Aquaporins

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-8
Short name:
AQP-8
Gene namesi
Name:Aqp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1195271 Aqp8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 84ExtracellularSequence analysisAdd BLAST27
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 107CytoplasmicSequence analysis2
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 156ExtracellularSequence analysisAdd BLAST28
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 183CytoplasmicSequence analysis6
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 228ExtracellularSequence analysisAdd BLAST24
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 261CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639621 – 261Aquaporin-8Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP56404
PaxDbiP56404
PRIDEiP56404

Expressioni

Tissue specificityi

Colon, liver, heart and placenta.

Gene expression databases

BgeeiENSMUSG00000030762 Expressed in 76 organ(s), highest expression level in colon
CleanExiMM_AQP8
ExpressionAtlasiP56404 baseline and differential
GenevisibleiP56404 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033023

Structurei

3D structure databases

ProteinModelPortaliP56404
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi92 – 94NPA 13
Motifi210 – 212NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00760000119223
HOGENOMiHOG000288286
HOVERGENiHBG100478
InParanoidiP56404
KOiK09869
OrthoDBiEOG091G166T
PhylomeDBiP56404
TreeFamiTF312940

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023277 Aquaporin_8
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02020 AQUAPORIN8
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P56404-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGEQTPMCS MDLPEVKVKT SMAGRCRVFW YEQYVQPCIV ELVGSALFIF
60 70 80 90 100
IGCLSVIENS PNTGLLQPAL AHGLALGLII ATLGNISGGH FNPAVSLAVT
110 120 130 140 150
VIGGLKTMLL IPYWISQLFG GLIGAALAKV VSPEERFWNA SGAAFAIVQE
160 170 180 190 200
QEQVAEALGI EIILTMLLVL AVCMGAVNEK TMGPLAPFSI GFSVIVDILA
210 220 230 240 250
GGSISGACMN PARAFGPAVM AGYWDFHWIY WLGPLLAGLF VGLLIRLLIG
260
DEKTRLILKS R
Length:261
Mass (Da):27,797
Last modified:July 15, 1998 - v1
Checksum:i9CB48ACA1FB5E589
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0X1KG59A0A0X1KG59_MOUSE
Aquaporin-8
Aqp8
260Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5Missing in AAH10982 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018952 mRNA Translation: AAB68847.1
AF107543
, AF107538, AF107539, AF107540, AF107541, AF107542 Genomic DNA Translation: AAD55972.1
BC010982 mRNA Translation: AAH10982.1
CCDSiCCDS72038.1
PIRiJC5806
RefSeqiNP_001102515.1, NM_001109045.1
NP_031500.1, NM_007474.2
UniGeneiMm.273175

Genome annotation databases

EnsembliENSMUST00000098056; ENSMUSP00000095664; ENSMUSG00000030762
GeneIDi11833
KEGGimmu:11833
UCSCiuc012ftk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018952 mRNA Translation: AAB68847.1
AF107543
, AF107538, AF107539, AF107540, AF107541, AF107542 Genomic DNA Translation: AAD55972.1
BC010982 mRNA Translation: AAH10982.1
CCDSiCCDS72038.1
PIRiJC5806
RefSeqiNP_001102515.1, NM_001109045.1
NP_031500.1, NM_007474.2
UniGeneiMm.273175

3D structure databases

ProteinModelPortaliP56404
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033023

Proteomic databases

MaxQBiP56404
PaxDbiP56404
PRIDEiP56404

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098056; ENSMUSP00000095664; ENSMUSG00000030762
GeneIDi11833
KEGGimmu:11833
UCSCiuc012ftk.2 mouse

Organism-specific databases

CTDi343
MGIiMGI:1195271 Aqp8

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00760000119223
HOGENOMiHOG000288286
HOVERGENiHBG100478
InParanoidiP56404
KOiK09869
OrthoDBiEOG091G166T
PhylomeDBiP56404
TreeFamiTF312940

Enzyme and pathway databases

ReactomeiR-MMU-432047 Passive transport by Aquaporins

Miscellaneous databases

PROiPR:P56404
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030762 Expressed in 76 organ(s), highest expression level in colon
CleanExiMM_AQP8
ExpressionAtlasiP56404 baseline and differential
GenevisibleiP56404 MM

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023277 Aquaporin_8
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02020 AQUAPORIN8
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAQP8_MOUSE
AccessioniPrimary (citable) accession number: P56404
Secondary accession number(s): Q91XC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again