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Protein

Platelet glycoprotein Ib beta chain

Gene

Gp1bb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.By similarity

Miscellaneous

Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: UniProtKB-KW
  • cell adhesion Source: MGI

Keywordsi

Biological processBlood coagulation, Cell adhesion, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-430116 GP1b-IX-V activation signalling
R-MMU-75892 Platelet Adhesion to exposed collagen
R-MMU-76009 Platelet Aggregation (Plug Formation)

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein Ib beta chain
Short name:
GP-Ib beta
Short name:
GPIb-beta
Short name:
GPIbB
Alternative name(s):
CD_antigen: CD42c
Gene namesi
Name:Gp1bb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:107852 Gp1bb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 147ExtracellularSequence analysisAdd BLAST121
Transmembranei148 – 172HelicalSequence analysisAdd BLAST25
Topological domaini173 – 206CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000002134627 – 206Platelet glycoprotein Ib beta chainAdd BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 32By similarity
Disulfide bondi30 ↔ 39By similarity
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi93 ↔ 118By similarity
Disulfide bondi95 ↔ 141By similarity
Disulfide bondi147Interchain (with C-608 or C-609 in GP1BA)By similarity
Modified residuei186PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei193PhosphothreonineCombined sources1
Modified residuei200PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP56400
PaxDbiP56400
PRIDEiP56400

PTM databases

iPTMnetiP56400
PhosphoSitePlusiP56400

Expressioni

Gene expression databases

BgeeiENSMUSG00000050761 Expressed in 165 organ(s), highest expression level in blood
CleanExiMM_GP1BB
ExpressionAtlasiP56400 baseline and differential
GenevisibleiP56400 MM

Interactioni

Subunit structurei

Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200004, 1 interactor
ComplexPortaliCPX-115 Glycoprotein Ib-IX-V complex
CPX-118 Glycoprotein Ib-IX-V-Filamin-A complex
STRINGi10090.ENSMUSP00000059270

Structurei

3D structure databases

ProteinModelPortaliP56400
SMRiP56400
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 55LRRNTAdd BLAST29
Repeati60 – 83LRRAdd BLAST24
Domaini89 – 143LRRCTAdd BLAST55

Keywords - Domaini

Leucine-rich repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00530000064244
HOVERGENiHBG051791
InParanoidiP56400
KOiK06262
OMAiYRDLRCA
PhylomeDBiP56400

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P56400-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSRPRGALS LLLLLLALLS RPASGCPAPC SCAGTLVDCG RRGLTWASLP
60 70 80 90 100
AAFPPDTTEL VLTGNNLTAL PPGLLDALPA LRAAHLGANP WRCDCRLLPL
110 120 130 140 150
RAWLAGRPER APYRDLRCVA PPALRGRLLP YVAEDELRAA CAPGLLCWGA
160 170 180 190 200
LVAQLALLVL GLLHALLLAL LLGRLRRLRA RARARSIQEF SLTAPLVAES

ARGGAS
Length:206
Mass (Da):21,763
Last modified:July 15, 1998 - v1
Checksum:iAC4BCB4DFA226F1D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RR03B2RR03_MOUSE
Glycoprotein Ib, beta polypeptide
Gp1bb
214Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001419 Genomic DNA Translation: BAA22424.1
CCDSiCCDS49787.1
RefSeqiNP_034457.1, NM_010327.2
UniGeneiMm.475622

Genome annotation databases

EnsembliENSMUST00000167388; ENSMUSP00000126292; ENSMUSG00000050761
GeneIDi14724
KEGGimmu:14724
UCSCiuc007yoi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001419 Genomic DNA Translation: BAA22424.1
CCDSiCCDS49787.1
RefSeqiNP_034457.1, NM_010327.2
UniGeneiMm.475622

3D structure databases

ProteinModelPortaliP56400
SMRiP56400
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200004, 1 interactor
ComplexPortaliCPX-115 Glycoprotein Ib-IX-V complex
CPX-118 Glycoprotein Ib-IX-V-Filamin-A complex
STRINGi10090.ENSMUSP00000059270

PTM databases

iPTMnetiP56400
PhosphoSitePlusiP56400

Proteomic databases

MaxQBiP56400
PaxDbiP56400
PRIDEiP56400

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167388; ENSMUSP00000126292; ENSMUSG00000050761
GeneIDi14724
KEGGimmu:14724
UCSCiuc007yoi.1 mouse

Organism-specific databases

CTDi2812
MGIiMGI:107852 Gp1bb

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00530000064244
HOVERGENiHBG051791
InParanoidiP56400
KOiK06262
OMAiYRDLRCA
PhylomeDBiP56400

Enzyme and pathway databases

ReactomeiR-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-430116 GP1b-IX-V activation signalling
R-MMU-75892 Platelet Adhesion to exposed collagen
R-MMU-76009 Platelet Aggregation (Plug Formation)

Miscellaneous databases

PROiPR:P56400
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050761 Expressed in 165 organ(s), highest expression level in blood
CleanExiMM_GP1BB
ExpressionAtlasiP56400 baseline and differential
GenevisibleiP56400 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGP1BB_MOUSE
AccessioniPrimary (citable) accession number: P56400
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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