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Protein

Cytochrome b5

Gene

Cyb5a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. It is also involved in several steps of the sterol biosynthesis pathway, particularly in the C-5 double bond introduction during the C-5 desaturation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi68Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • enzyme binding Source: MGI
  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • stearoyl-CoA 9-desaturase activity Source: MGI

GO - Biological processi

  • fatty acid metabolic process Source: MGI
  • response to cadmium ion Source: Ensembl

Keywordsi

Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-196836 Vitamin C (ascorbate) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b5
Gene namesi
Name:Cyb5a
Synonyms:Cyb5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1926952 Cyb5a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei109 – 131HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001660112 – 134Cytochrome b5Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei7N6-acetyllysineCombined sources1
Modified residuei10N6-acetyllysineCombined sources1
Modified residuei19N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP56395
PaxDbiP56395
PeptideAtlasiP56395
PRIDEiP56395
TopDownProteomicsiP56395

2D gel databases

REPRODUCTION-2DPAGEiIPI00230113
P56395
SWISS-2DPAGEiP56395

PTM databases

iPTMnetiP56395
PhosphoSitePlusiP56395

Expressioni

Gene expression databases

BgeeiENSMUSG00000024646
CleanExiMM_CYB5
ExpressionAtlasiP56395 baseline and differential
GenevisibleiP56395 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi224948, 1 interactor
IntActiP56395, 5 interactors
MINTiP56395
STRINGi10090.ENSMUSP00000124480

Structurei

3D structure databases

ProteinModelPortaliP56395
SMRiP56395
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 85Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the cytochrome b5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0537 Eukaryota
COG5274 LUCA
GeneTreeiENSGT00510000046507
HOGENOMiHOG000039853
HOVERGENiHBG002653
InParanoidiP56395
OMAiFKSTWII
OrthoDBiEOG091G17G8
PhylomeDBiP56395
TreeFamiTF314537

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PRINTSiPR00363 CYTOCHROMEB5
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQSDKDVK YYTLEEIQKH KDSKSTWVIL HHKVYDLTKF LEEHPGGEEV
60 70 80 90 100
LREQAGGDAT ENFEDVGHST DARELSKTYI IGELHPDDRS KIAKPSDTLI
110 120 130
TTVESNSSWW TNWVIPAISA LAVALMYRLY MAED
Length:134
Mass (Da):15,241
Last modified:January 23, 2007 - v2
Checksum:iC2540A68320107C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024341 mRNA Translation: AAH24341.1
CCDSiCCDS29385.1
RefSeqiNP_080073.1, NM_025797.4
UniGeneiMm.31018

Genome annotation databases

EnsembliENSMUST00000160180; ENSMUSP00000124480; ENSMUSG00000024646
GeneIDi109672
KEGGimmu:109672
UCSCiuc008fuw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCYB5_MOUSE
AccessioniPrimary (citable) accession number: P56395
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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