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Protein

Cytochrome c oxidase copper chaperone

Gene

Cox17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23Copper1 Publication1
Metal bindingi24Copper1 Publication1

GO - Molecular functioni

  • copper chaperone activity Source: UniProtKB
  • copper ion binding Source: MGI
  • cuprous ion binding Source: MGI
  • enzyme activator activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase copper chaperone
Gene namesi
Name:Cox17
Synonyms:Cox17a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1333806 Cox17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23C → G: Significant reduction of copper binding; when associated with G-24 and G-26. 1 Publication1
Mutagenesisi24C → G: Significant reduction of copper binding; when associated with G-23 and G-26. 1 Publication1
Mutagenesisi26C → G: Significant reduction of copper binding; when associated with G-23 and G-24. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135391 – 63Cytochrome c oxidase copper chaperoneAdd BLAST63

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 55PROSITE-ProRule annotation
Disulfide bondi36 ↔ 45PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP56394
PaxDbiP56394
PeptideAtlasiP56394
PRIDEiP56394

PTM databases

iPTMnetiP56394
PhosphoSitePlusiP56394

Expressioni

Gene expression databases

BgeeiENSMUSG00000046516 Expressed in 265 organ(s), highest expression level in aortic valve
ExpressionAtlasiP56394 baseline and differential
GenevisibleiP56394 MM

Interactioni

Subunit structurei

Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure.By similarity

Protein-protein interaction databases

IntActiP56394, 1 interactor
MINTiP56394
STRINGi10090.ENSMUSP00000112386

Structurei

3D structure databases

ProteinModelPortaliP56394
SMRiP56394
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 63CHCHPROSITE-ProRule annotationAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi26 – 36Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi45 – 55Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 27Ala/Pro-richAdd BLAST26

Sequence similaritiesi

Belongs to the COX17 family.Curated

Phylogenomic databases

eggNOGiKOG3496 Eukaryota
ENOG410XVYQ LUCA
GeneTreeiENSGT00390000002329
HOGENOMiHOG000195037
HOVERGENiHBG054258
InParanoidiP56394
KOiK02260
OMAiCCACPQT
OrthoDBiEOG091G1BKO
PhylomeDBiP56394
TreeFamiTF105074

Family and domain databases

InterProiView protein in InterPro
IPR009069 Cys_alpha_HP_mot_SF
IPR007745 Cyt_c_oxidase_Cu-chaperone
PANTHERiPTHR16719 PTHR16719, 1 hit
PfamiView protein in Pfam
PF05051 COX17, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014904 Cyt_c_oxidase_Cu-chaperone, 1 hit
SUPFAMiSSF47072 SSF47072, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequencei

Sequence statusi: Complete.

P56394-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGLAAASPA PPEAQEKKPL KPCCACPETK KARDACIIEK GEEHCGHLIE
60
AHKECMRALG FKI
Length:63
Mass (Da):6,784
Last modified:January 23, 2007 - v2
Checksum:i26787FE131159562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA168035 mRNA No translation available.
BC048668 mRNA Translation: AAH48668.1
CCDSiCCDS28165.1
RefSeqiNP_001017429.1, NM_001017429.2
XP_006521813.1, XM_006521750.3
UniGeneiMm.27396

Genome annotation databases

EnsembliENSMUST00000050273; ENSMUSP00000054086; ENSMUSG00000046516
ENSMUST00000119704; ENSMUSP00000112386; ENSMUSG00000095464
ENSMUST00000120495; ENSMUSP00000113430; ENSMUSG00000046516
GeneIDi12856
KEGGimmu:12856
UCSCiuc007zet.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA168035 mRNA No translation available.
BC048668 mRNA Translation: AAH48668.1
CCDSiCCDS28165.1
RefSeqiNP_001017429.1, NM_001017429.2
XP_006521813.1, XM_006521750.3
UniGeneiMm.27396

3D structure databases

ProteinModelPortaliP56394
SMRiP56394
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56394, 1 interactor
MINTiP56394
STRINGi10090.ENSMUSP00000112386

PTM databases

iPTMnetiP56394
PhosphoSitePlusiP56394

Proteomic databases

EPDiP56394
PaxDbiP56394
PeptideAtlasiP56394
PRIDEiP56394

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050273; ENSMUSP00000054086; ENSMUSG00000046516
ENSMUST00000119704; ENSMUSP00000112386; ENSMUSG00000095464
ENSMUST00000120495; ENSMUSP00000113430; ENSMUSG00000046516
GeneIDi12856
KEGGimmu:12856
UCSCiuc007zet.1 mouse

Organism-specific databases

CTDi10063
MGIiMGI:1333806 Cox17

Phylogenomic databases

eggNOGiKOG3496 Eukaryota
ENOG410XVYQ LUCA
GeneTreeiENSGT00390000002329
HOGENOMiHOG000195037
HOVERGENiHBG054258
InParanoidiP56394
KOiK02260
OMAiCCACPQT
OrthoDBiEOG091G1BKO
PhylomeDBiP56394
TreeFamiTF105074

Miscellaneous databases

ChiTaRSiCox17 mouse
PROiPR:P56394
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046516 Expressed in 265 organ(s), highest expression level in aortic valve
ExpressionAtlasiP56394 baseline and differential
GenevisibleiP56394 MM

Family and domain databases

InterProiView protein in InterPro
IPR009069 Cys_alpha_HP_mot_SF
IPR007745 Cyt_c_oxidase_Cu-chaperone
PANTHERiPTHR16719 PTHR16719, 1 hit
PfamiView protein in Pfam
PF05051 COX17, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014904 Cyt_c_oxidase_Cu-chaperone, 1 hit
SUPFAMiSSF47072 SSF47072, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX17_MOUSE
AccessioniPrimary (citable) accession number: P56394
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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