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Protein

Cytochrome c oxidase subunit 7B, mitochondrial

Gene

Cox7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIb
Gene namesi
Name:Cox7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1913392 Cox7b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 32Mitochondrial matrixBy similarity8
Transmembranei33 – 59HelicalBy similarityAdd BLAST27
Topological domaini60 – 80Mitochondrial intermembraneBy similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionBy similarityAdd BLAST24
ChainiPRO_000000615925 – 80Cytochrome c oxidase subunit 7B, mitochondrialAdd BLAST56

Proteomic databases

PaxDbiP56393
PeptideAtlasiP56393
PRIDEiP56393
TopDownProteomicsiP56393

PTM databases

iPTMnetiP56393
PhosphoSitePlusiP56393

Expressioni

Gene expression databases

BgeeiENSMUSG00000031231 Expressed in 107 organ(s), highest expression level in brown adipose tissue
CleanExiMM_COX7B
ExpressionAtlasiP56393 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi211245, 1 interactor
CORUMiP56393
STRINGi10090.ENSMUSP00000033582

Structurei

3D structure databases

ProteinModelPortaliP56393
SMRiP56393
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIb family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3GK Eukaryota
ENOG4112BN9 LUCA
GeneTreeiENSGT00390000012178
HOGENOMiHOG000059529
HOVERGENiHBG051092
InParanoidiP56393
KOiK02271
OMAiAVWAYTA
OrthoDBiEOG091G1342
PhylomeDBiP56393
TreeFamiTF105068

Family and domain databases

CDDicd01403 Cyt_c_Oxidase_VIIb, 1 hit
Gene3Di4.10.51.10, 1 hit
InterProiView protein in InterPro
IPR008433 Cyt_c_oxidase_suVIIB
IPR023272 Cyt_c_oxidase_suVIIB_dom_sf
PANTHERiPTHR16716 PTHR16716, 1 hit
PfamiView protein in Pfam
PF05392 COX7B, 1 hit
SUPFAMiSSF81423 SSF81423, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56393-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPLAKNALS RLQVRSIQQV VARQSHQKRA PSFHDKYGNA ILAGGAIFCV
60 70 80
STWTYTATQI GIEWNMSPVG RVTPKEWRDQ
Length:80
Mass (Da):9,011
Last modified:July 15, 1998 - v1
Checksum:iD68B28A9FAF1E9A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA033366 mRNA No translation available.
AA049075 mRNA No translation available.
AA032894 mRNA No translation available.
AA051290 mRNA No translation available.
AA086918 mRNA No translation available.
AA032640 mRNA No translation available.
AK002593 mRNA Translation: BAB22214.1
BC024350 mRNA Translation: AAH24350.1
CCDSiCCDS41096.1
RefSeqiNP_079655.1, NM_025379.2
UniGeneiMm.197728

Genome annotation databases

EnsembliENSMUST00000033582; ENSMUSP00000033582; ENSMUSG00000031231
GeneIDi66142
KEGGimmu:66142
UCSCiuc009ubk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA033366 mRNA No translation available.
AA049075 mRNA No translation available.
AA032894 mRNA No translation available.
AA051290 mRNA No translation available.
AA086918 mRNA No translation available.
AA032640 mRNA No translation available.
AK002593 mRNA Translation: BAB22214.1
BC024350 mRNA Translation: AAH24350.1
CCDSiCCDS41096.1
RefSeqiNP_079655.1, NM_025379.2
UniGeneiMm.197728

3D structure databases

ProteinModelPortaliP56393
SMRiP56393
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211245, 1 interactor
CORUMiP56393
STRINGi10090.ENSMUSP00000033582

PTM databases

iPTMnetiP56393
PhosphoSitePlusiP56393

Proteomic databases

PaxDbiP56393
PeptideAtlasiP56393
PRIDEiP56393
TopDownProteomicsiP56393

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033582; ENSMUSP00000033582; ENSMUSG00000031231
GeneIDi66142
KEGGimmu:66142
UCSCiuc009ubk.1 mouse

Organism-specific databases

CTDi1349
MGIiMGI:1913392 Cox7b

Phylogenomic databases

eggNOGiENOG410J3GK Eukaryota
ENOG4112BN9 LUCA
GeneTreeiENSGT00390000012178
HOGENOMiHOG000059529
HOVERGENiHBG051092
InParanoidiP56393
KOiK02271
OMAiAVWAYTA
OrthoDBiEOG091G1342
PhylomeDBiP56393
TreeFamiTF105068

Miscellaneous databases

ChiTaRSiCox7b mouse
PROiPR:P56393
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031231 Expressed in 107 organ(s), highest expression level in brown adipose tissue
CleanExiMM_COX7B
ExpressionAtlasiP56393 baseline and differential

Family and domain databases

CDDicd01403 Cyt_c_Oxidase_VIIb, 1 hit
Gene3Di4.10.51.10, 1 hit
InterProiView protein in InterPro
IPR008433 Cyt_c_oxidase_suVIIB
IPR023272 Cyt_c_oxidase_suVIIB_dom_sf
PANTHERiPTHR16716 PTHR16716, 1 hit
PfamiView protein in Pfam
PF05392 COX7B, 1 hit
SUPFAMiSSF81423 SSF81423, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX7B_MOUSE
AccessioniPrimary (citable) accession number: P56393
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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