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Protein

Cyclin-dependent kinases regulatory subunit 2

Gene

Cks2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

GO - Molecular functioni

  • chromatin binding Source: MGI
  • cyclin-dependent protein serine/threonine kinase activator activity Source: GO_Central
  • histone binding Source: GO_Central
  • protein kinase binding Source: GO_Central
  • ubiquitin binding Source: GO_Central

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cell proliferation Source: MGI
  • meiosis I Source: MGI
  • mitotic cell cycle phase transition Source: MGI
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • regulation of mitotic cell cycle Source: GO_Central
  • regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 2
Short name:
CKS-2
Gene namesi
Name:Cks2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913447 Cks2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062381 – 79Cyclin-dependent kinases regulatory subunit 2Add BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP56390
PaxDbiP56390
PeptideAtlasiP56390
PRIDEiP56390

PTM databases

iPTMnetiP56390
PhosphoSitePlusiP56390

Expressioni

Gene expression databases

BgeeiENSMUSG00000062248 Expressed in 21 organ(s), highest expression level in thymus
CleanExiMM_CKS2
ExpressionAtlasiP56390 baseline and differential
GenevisibleiP56390 MM

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075250

Structurei

3D structure databases

ProteinModelPortaliP56390
SMRiP56390
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiKOG3484 Eukaryota
ENOG4111UAN LUCA
GeneTreeiENSGT00390000011006
HOVERGENiHBG003626
InParanoidiP56390
KOiK02219
OMAiKHVPKSH
OrthoDBiEOG091G18GQ
PhylomeDBiP56390
TreeFamiTF101142

Family and domain databases

Gene3Di3.30.170.10, 1 hit
InterProiView protein in InterPro
IPR000789 Cyclin-dep_kinase_reg-sub
IPR036858 Cyclin-dep_kinase_reg-sub_sf
PfamiView protein in Pfam
PF01111 CKS, 1 hit
PRINTSiPR00296 CYCLINKINASE
SMARTiView protein in SMART
SM01084 CKS, 1 hit
SUPFAMiSSF55637 SSF55637, 1 hit
PROSITEiView protein in PROSITE
PS00944 CKS_1, 1 hit
PS00945 CKS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P56390-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ
60 70
SLGWVHYMIH EPEPHILLFR RPLPKEQQK
Length:79
Mass (Da):9,874
Last modified:July 15, 1998 - v1
Checksum:i811B5926D91EEC5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA289122 mRNA No translation available.
AA041913 mRNA No translation available.
AK002451 mRNA Translation: BAB22110.1
BC022647 mRNA Translation: AAH22647.1
CCDSiCCDS36664.1
RefSeqiNP_079691.1, NM_025415.3
UniGeneiMm.222228

Genome annotation databases

EnsembliENSMUST00000075853; ENSMUSP00000075250; ENSMUSG00000062248
GeneIDi66197
KEGGimmu:66197
UCSCiuc007qmh.2 mouse

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AA289122 mRNA No translation available.
AA041913 mRNA No translation available.
AK002451 mRNA Translation: BAB22110.1
BC022647 mRNA Translation: AAH22647.1
CCDSiCCDS36664.1
RefSeqiNP_079691.1, NM_025415.3
UniGeneiMm.222228

3D structure databases

ProteinModelPortaliP56390
SMRiP56390
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075250

PTM databases

iPTMnetiP56390
PhosphoSitePlusiP56390

Proteomic databases

EPDiP56390
PaxDbiP56390
PeptideAtlasiP56390
PRIDEiP56390

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075853; ENSMUSP00000075250; ENSMUSG00000062248
GeneIDi66197
KEGGimmu:66197
UCSCiuc007qmh.2 mouse

Organism-specific databases

CTDi1164
MGIiMGI:1913447 Cks2

Phylogenomic databases

eggNOGiKOG3484 Eukaryota
ENOG4111UAN LUCA
GeneTreeiENSGT00390000011006
HOVERGENiHBG003626
InParanoidiP56390
KOiK02219
OMAiKHVPKSH
OrthoDBiEOG091G18GQ
PhylomeDBiP56390
TreeFamiTF101142

Miscellaneous databases

PROiPR:P56390
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062248 Expressed in 21 organ(s), highest expression level in thymus
CleanExiMM_CKS2
ExpressionAtlasiP56390 baseline and differential
GenevisibleiP56390 MM

Family and domain databases

Gene3Di3.30.170.10, 1 hit
InterProiView protein in InterPro
IPR000789 Cyclin-dep_kinase_reg-sub
IPR036858 Cyclin-dep_kinase_reg-sub_sf
PfamiView protein in Pfam
PF01111 CKS, 1 hit
PRINTSiPR00296 CYCLINKINASE
SMARTiView protein in SMART
SM01084 CKS, 1 hit
SUPFAMiSSF55637 SSF55637, 1 hit
PROSITEiView protein in PROSITE
PS00944 CKS_1, 1 hit
PS00945 CKS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCKS2_MOUSE
AccessioniPrimary (citable) accession number: P56390
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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