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Protein

ATP synthase subunit e, mitochondrial

Gene

ATP5ME

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.

GO - Molecular functioni

  • proton transmembrane transporter activity Source: InterPro
  • transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • ATP biosynthetic process Source: Reactome
  • cristae formation Source: Reactome
  • mitochondrial ATP synthesis coupled proton transport Source: UniProtKB

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit e, mitochondrialCurated
Short name:
ATPase subunit e
Alternative name(s):
ATP synthase membrane subunit eCurated
Cleaved into the following chain:
Gene namesi
Name:ATP5MEImported
Synonyms:ATP5IImported, ATP5K
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000169020.9
HGNCiHGNC:846 ATP5ME
MIMi601519 gene
neXtProtiNX_P56385

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169020
PharmGKBiPA25136

Polymorphism and mutation databases

BioMutaiATP5I
DMDMi3023369

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004343461 – 69ATP synthase subunit e, mitochondrialAdd BLAST69
Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00000716842 – 69ATP synthase subunit e, mitochondrial, N-terminally processedAdd BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-acetyllysineBy similarity1
Modified residuei66PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP56385
MaxQBiP56385
PaxDbiP56385
PeptideAtlasiP56385
PRIDEiP56385
ProteomicsDBi56918
TopDownProteomicsiP56385

PTM databases

iPTMnetiP56385
PhosphoSitePlusiP56385

Expressioni

Gene expression databases

BgeeiENSG00000169020
CleanExiHS_ATP5I
GenevisibleiP56385 HS

Organism-specific databases

HPAiHPA035010

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5ME, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi107005, 49 interactors
CORUMiP56385
IntActiP56385, 27 interactors
MINTiP56385
STRINGi9606.ENSP00000306003

Structurei

3D structure databases

ProteinModelPortaliP56385
SMRiP56385
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase e subunit family.Curated

Phylogenomic databases

eggNOGiKOG4326 Eukaryota
ENOG410XYSS LUCA
GeneTreeiENSGT00390000005102
HOGENOMiHOG000231826
HOVERGENiHBG050613
InParanoidiP56385
KOiK02129
OMAiEQERIYK
OrthoDBiEOG091G13NK
PhylomeDBiP56385
TreeFamiTF314719

Family and domain databases

InterProiView protein in InterPro
IPR008386 ATP_synth_F0_esu_mt
PANTHERiPTHR12427 PTHR12427, 1 hit
PfamiView protein in Pfam
PF05680 ATP-synt_E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P56385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPPVQVSPL IKLGRYSALF LGVAYGATRY NYLKPRAEEE RRIAAEEKKK
60
QDELKRIARE LAEDDSILK
Length:69
Mass (Da):7,933
Last modified:January 23, 2007 - v2
Checksum:iE4FF2B855F4535DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50371 mRNA Translation: BAA23322.1
BT006922 mRNA Translation: AAP35568.1
BC003679 mRNA Translation: AAH03679.1
BC105610 mRNA Translation: AAI05611.1
CCDSiCCDS3337.1
RefSeqiNP_009031.1, NM_007100.3
UniGeneiHs.85539

Genome annotation databases

EnsembliENST00000304312; ENSP00000306003; ENSG00000169020
GeneIDi521
KEGGihsa:521
UCSCiuc003gas.3 human

Similar proteinsi

Entry informationi

Entry nameiATP5I_HUMAN
AccessioniPrimary (citable) accession number: P56385
Secondary accession number(s): Q0D2L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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