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Protein

ATP synthase subunit epsilon, mitochondrial

Gene

Atp5f1e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit epsilon, mitochondrialCurated
Short name:
ATPase subunit epsilon
Alternative name(s):
ATP synthase F1 subunit epsilonBy similarity
Gene namesi
Name:Atp5f1eBy similarity
Synonyms:Atp5e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1855697 Atp5e

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000716631 – 52ATP synthase subunit epsilon, mitochondrialAdd BLAST52

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21N6-acetyllysine; alternateCombined sources1
Modified residuei21N6-succinyllysine; alternateCombined sources1
Modified residuei32N6-acetyllysine; alternateCombined sources1
Modified residuei32N6-succinyllysine; alternateCombined sources1
Modified residuei37N6-acetyllysine; alternateCombined sources1
Modified residuei37N6-succinyllysine; alternateCombined sources1
Modified residuei44N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP56382
PaxDbiP56382
PeptideAtlasiP56382
PRIDEiP56382
TopDownProteomicsiP56382

PTM databases

iPTMnetiP56382
PhosphoSitePlusiP56382

Expressioni

Gene expression databases

BgeeiENSMUSG00000016252
ExpressionAtlasiP56382 baseline and differential
GenevisibleiP56382 MM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5ME, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016396

Structurei

3D structure databases

ProteinModelPortaliP56382
SMRiP56382
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ATPase epsilon family.Curated

Phylogenomic databases

eggNOGiKOG3495 Eukaryota
ENOG410Y5P5 LUCA
GeneTreeiENSGT00390000015470
HOGENOMiHOG000214506
HOVERGENiHBG050611
InParanoidiP56382
KOiK02135
OMAiANAMKTS
OrthoDBiEOG091G16RI
PhylomeDBiP56382
TreeFamiTF300278

Family and domain databases

CDDicd12153 F1-ATPase_epsilon, 1 hit
Gene3Di1.10.1620.20, 1 hit
InterProiView protein in InterPro
IPR006721 ATP_synth_F1_esu_mt
IPR036742 ATP_synth_F1_esu_sf_mt
PANTHERiPTHR12448 PTHR12448, 1 hit
PfamiView protein in Pfam
PF04627 ATP-synt_Eps, 1 hit
SUPFAMiSSF48690 SSF48690, 1 hit

Sequencei

Sequence statusi: Complete.

P56382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAYWRQAGL SYIRFSQICA KAVRDALKTE FKANAEKTSG SSIKIVKVSK

KE
Length:52
Mass (Da):5,838
Last modified:January 23, 2007 - v2
Checksum:i406371C227DAA127
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024339 mRNA Translation: AAH24339.1
CCDSiCCDS38360.1
RefSeqiNP_080259.1, NM_025983.3
UniGeneiMm.20841

Genome annotation databases

EnsembliENSMUST00000016396; ENSMUSP00000016396; ENSMUSG00000016252
GeneIDi67126
KEGGimmu:67126
UCSCiuc008off.1 mouse

Similar proteinsi

Entry informationi

Entry nameiATP5E_MOUSE
AccessioniPrimary (citable) accession number: P56382
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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