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Protein

6.8 kDa mitochondrial proteolipid

Gene

MP68

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
6.8 kDa mitochondrial proteolipid
Gene namesi
Name:MP68
Synonyms:C14orf2
ORF Names:PRO1574
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000156411.9
HGNCiHGNC:1188 C14orf2
MIMi604573 gene
neXtProtiNX_P56378

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 38HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156411
PharmGKBiPA25514

Polymorphism and mutation databases

BioMutaiMP68

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643931 – 586.8 kDa mitochondrial proteolipidAdd BLAST58

Proteomic databases

EPDiP56378
MaxQBiP56378
PaxDbiP56378
PeptideAtlasiP56378
PRIDEiP56378
ProteomicsDBi56916
TopDownProteomicsiP56378-1 [P56378-1]

PTM databases

iPTMnetiP56378
PhosphoSitePlusiP56378

Expressioni

Gene expression databases

BgeeiENSG00000156411
CleanExiHS_C14orf2
ExpressionAtlasiP56378 baseline and differential
GenevisibleiP56378 HS

Organism-specific databases

HPAiHPA058978
HPA060520

Interactioni

Subunit structurei

Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5ME, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68.By similarity

Protein-protein interaction databases

BioGridi114928, 2 interactors
IntActiP56378, 3 interactors
STRINGi9606.ENSP00000401770

Structurei

3D structure databases

ProteinModelPortaliP56378
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JG1Q Eukaryota
ENOG4111AMJ LUCA
GeneTreeiENSGT00390000016760
HOGENOMiHOG000276668
HOVERGENiHBG000027
InParanoidiP56378
KOiK18193
OMAiDISHFQC
PhylomeDBiP56378
TreeFamiTF338412

Family and domain databases

InterProiView protein in InterPro
IPR012574 Mit_proteolip
PANTHERiPTHR15233 PTHR15233, 1 hit
PfamiView protein in Pfam
PF08039 Mit_proteolip, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P56378-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQSIIKNIW IPMKPYYTKV YQEIWIGMGL MGFIVYKIRA ADKRSKALKA

SAPAPGHH
Length:58
Mass (Da):6,662
Last modified:July 15, 1998 - v1
Checksum:i1B8A63046C0383F6
GO
Isoform 2 (identifier: P56378-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKLYGTRGSDISHFQCQM

Note: No experimental confirmation available.
Show »
Length:75
Mass (Da):8,615
Checksum:i71F6B3697603EAD9
GO

Sequence cautioni

The sequence EAW81849 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0145269I → V. Corresponds to variant dbSNP:rs1053419Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470431M → MKLYGTRGSDISHFQCQM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054175 mRNA Translation: AAC39909.1
AF116639 mRNA Translation: AAF71062.1
BX161388 mRNA Translation: CAD61878.1
AK312099 mRNA Translation: BAG35035.1
AL132712 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81849.1 Sequence problems.
CH471061 Genomic DNA Translation: EAW81850.1
BC000429 mRNA Translation: AAH00429.1
BC001944 mRNA Translation: AAH01944.1
CCDSiCCDS45169.1 [P56378-2]
CCDS9986.1 [P56378-1]
RefSeqiNP_001120865.1, NM_001127393.1 [P56378-2]
NP_004885.1, NM_004894.2 [P56378-1]
UniGeneiHs.109052

Genome annotation databases

EnsembliENST00000286953; ENSP00000286953; ENSG00000156411 [P56378-1]
ENST00000414262; ENSP00000401770; ENSG00000156411 [P56378-2]
ENST00000554880; ENSP00000452133; ENSG00000156411 [P56378-1]
ENST00000557040; ENSP00000450894; ENSG00000156411 [P56378-1]
GeneIDi9556
KEGGihsa:9556
UCSCiuc001yoi.5 human [P56378-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry namei68MP_HUMAN
AccessioniPrimary (citable) accession number: P56378
Secondary accession number(s): B2R588, G3V5Q3, Q86TT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: July 18, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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