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Entry version 189 (12 Aug 2020)
Sequence version 1 (15 Jul 1998)
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Protein

AP-1 complex subunit sigma-2

Gene

AP1S2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P56377

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-164940, Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-2132295, MHC class II antigen presentation
R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-432722, Golgi Associated Vesicle Biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-1 complex subunit sigma-2
Alternative name(s):
Adaptor protein complex AP-1 subunit sigma-1B
Adaptor-related protein complex 1 subunit sigma-1B
Clathrin assembly protein complex 1 sigma-1B small chain
Golgi adaptor HA1/AP1 adaptin sigma-1B subunit
Sigma 1B subunit of AP-1 clathrin
Sigma-adaptin 1B
Sigma1B-adaptin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AP1S2
ORF Names:DC22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000182287.13

Human Gene Nomenclature Database

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HGNCi
HGNC:560, AP1S2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300629, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P56377

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pettigrew syndrome (PGS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by mental retardation and additional highly variable features, including choreoathetosis, hydrocephalus, Dandy-Walker malformation, seizures, and iron or calcium deposition in the brain. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Related information in OMIM

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
8905

MalaCards human disease database

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MalaCardsi
AP1S2
MIMi304340, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000182287

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
85335, Fried syndrome
1568, X-linked intellectual disability-Dandy-Walker malformation-basal ganglia disease-seizures syndrome
85329, X-linked intellectual disability-hypotonia-facial dysmorphism-aggressive behavior syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24851

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P56377, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AP1S2

Domain mapping of disease mutations (DMDM)

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DMDMi
3023308

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001937991 – 157AP-1 complex subunit sigma-2Add BLAST157

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-1534
CPTAC-1535

Encyclopedia of Proteome Dynamics

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EPDi
P56377

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P56377

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P56377

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P56377

PeptideAtlas

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PeptideAtlasi
P56377

PRoteomics IDEntifications database

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PRIDEi
P56377

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
5052
56915 [P56377-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P56377

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P56377

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000182287, Expressed in corpus epididymis and 242 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P56377, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P56377, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000182287, Tissue enhanced (epididymis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds to MUC1.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114419, 44 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-5048, Ubiquitous AP-1 Adaptor complex, sigma1b variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P56377

Protein interaction database and analysis system

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IntActi
P56377, 36 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000444957

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P56377, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P56377

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0934, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00970000193372

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P56377

KEGG Orthology (KO)

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KOi
K12394

Database of Orthologous Groups

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OrthoDBi
1307450at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P56377

TreeFam database of animal gene trees

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TreeFami
TF312921

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016635, AP_complex_ssu
IPR022775, AP_mu_sigma_su
IPR000804, Clathrin_sm-chain_CS
IPR011012, Longin-like_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR11753, PTHR11753, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01217, Clat_adaptor_s, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF015588, AP_complex_sigma, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF64356, SSF64356, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00989, CLAT_ADAPTOR_S, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P56377-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQFMLLFSRQ GKLRLQKWYV PLSDKEKKKI TRELVQTVLA RKPKMCSFLE
60 70 80 90 100
WRDLKIVYKR YASLYFCCAI EDQDNELITL EIIHRYVELL DKYFGSVCEL
110 120 130 140 150
DIIFNFEKAY FILDEFLLGG EVQETSKKNV LKAIEQADLL QEEAETPRSV

LEEIGLT
Length:157
Mass (Da):18,615
Last modified:July 15, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD9F59119909D89C
GO
Isoform 2 (identifier: P56377-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPAGCPPHSTTASLPQHGDRGFPFAAAAAAGQAPPRPRPAAAM
     143-157: EAETPRSVLEEIGLT → KTETMYHSKSFIGFKKAY

Show »
Length:202
Mass (Da):23,225
Checksum:i69C7E1AE4CB98F02
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NH01A6NH01_HUMAN
AP complex subunit sigma
AP1S2
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SFB5F6SFB5_HUMAN
AP complex subunit sigma
AP1S2
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y673H0Y673_HUMAN
AP complex subunit sigma
AP1S2
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZG6H7BZG6_HUMAN
AP complex subunit sigma
AP1S2
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHW1A0A5F9ZHW1_HUMAN
AP complex subunit sigma
AP1S2
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHX2A0A5F9ZHX2_HUMAN
AP complex subunit sigma
AP1S2
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZI43A0A5F9ZI43_HUMAN
AP complex subunit sigma
AP1S2
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG44595 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → L in AAG44595 (Ref. 2) Curated1
Sequence conflicti72 – 74DQD → ESRN in AAC72946 (Ref. 7) Curated3
Sequence conflicti96 – 98SVC → QCL in AAC72946 (Ref. 7) Curated3
Sequence conflicti143E → EE in AAG44595 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0536711M → MPAGCPPHSTTASLPQHGDR GFPFAAAAAAGQAPPRPRPA AAM in isoform 2. 1 Publication1
Alternative sequenceiVSP_053672143 – 157EAETP…EIGLT → KTETMYHSKSFIGFKKAY in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB015320 mRNA Translation: BAA33392.1
AF251295 mRNA Translation: AAG44595.1 Different initiation.
BT006738 mRNA Translation: AAP35384.1
AK299921 mRNA Translation: BAG61756.1
AC004106 Genomic DNA No translation available.
BC001117 mRNA Translation: AAH01117.1
BC071867 mRNA Translation: AAH71867.1
AF091077 mRNA Translation: AAC72946.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14173.1 [P56377-1]

NCBI Reference Sequences

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RefSeqi
NP_003907.3, NM_003916.4 [P56377-1]
XP_011543901.1, XM_011545599.1
XP_016885414.1, XM_017029925.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329235; ENSP00000328789; ENSG00000182287 [P56377-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8905

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8905

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015320 mRNA Translation: BAA33392.1
AF251295 mRNA Translation: AAG44595.1 Different initiation.
BT006738 mRNA Translation: AAP35384.1
AK299921 mRNA Translation: BAG61756.1
AC004106 Genomic DNA No translation available.
BC001117 mRNA Translation: AAH01117.1
BC071867 mRNA Translation: AAH71867.1
AF091077 mRNA Translation: AAC72946.1
CCDSiCCDS14173.1 [P56377-1]
RefSeqiNP_003907.3, NM_003916.4 [P56377-1]
XP_011543901.1, XM_011545599.1
XP_016885414.1, XM_017029925.1

3D structure databases

SMRiP56377
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114419, 44 interactors
ComplexPortaliCPX-5048, Ubiquitous AP-1 Adaptor complex, sigma1b variant
CORUMiP56377
IntActiP56377, 36 interactors
STRINGi9606.ENSP00000444957

PTM databases

iPTMnetiP56377
PhosphoSitePlusiP56377

Polymorphism and mutation databases

BioMutaiAP1S2
DMDMi3023308

Proteomic databases

CPTACiCPTAC-1534
CPTAC-1535
EPDiP56377
jPOSTiP56377
MassIVEiP56377
PaxDbiP56377
PeptideAtlasiP56377
PRIDEiP56377
ProteomicsDBi5052
56915 [P56377-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23979, 67 antibodies

The DNASU plasmid repository

More...
DNASUi
8905

Genome annotation databases

EnsembliENST00000329235; ENSP00000328789; ENSG00000182287 [P56377-1]
GeneIDi8905
KEGGihsa:8905

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8905
DisGeNETi8905
EuPathDBiHostDB:ENSG00000182287.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AP1S2
HGNCiHGNC:560, AP1S2
HPAiENSG00000182287, Tissue enhanced (epididymis)
MalaCardsiAP1S2
MIMi300629, gene
304340, phenotype
neXtProtiNX_P56377
OpenTargetsiENSG00000182287
Orphaneti85335, Fried syndrome
1568, X-linked intellectual disability-Dandy-Walker malformation-basal ganglia disease-seizures syndrome
85329, X-linked intellectual disability-hypotonia-facial dysmorphism-aggressive behavior syndrome
PharmGKBiPA24851

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0934, Eukaryota
GeneTreeiENSGT00970000193372
InParanoidiP56377
KOiK12394
OrthoDBi1307450at2759
PhylomeDBiP56377
TreeFamiTF312921

Enzyme and pathway databases

PathwayCommonsiP56377
ReactomeiR-HSA-164940, Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-2132295, MHC class II antigen presentation
R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-432722, Golgi Associated Vesicle Biogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8905, 144 hits in 495 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AP1S2, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
AP1S2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8905
PharosiP56377, Tbio

Protein Ontology

More...
PROi
PR:P56377
RNActiP56377, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000182287, Expressed in corpus epididymis and 242 other tissues
ExpressionAtlasiP56377, baseline and differential
GenevisibleiP56377, HS

Family and domain databases

InterProiView protein in InterPro
IPR016635, AP_complex_ssu
IPR022775, AP_mu_sigma_su
IPR000804, Clathrin_sm-chain_CS
IPR011012, Longin-like_dom_sf
PANTHERiPTHR11753, PTHR11753, 1 hit
PfamiView protein in Pfam
PF01217, Clat_adaptor_s, 1 hit
PIRSFiPIRSF015588, AP_complex_sigma, 1 hit
SUPFAMiSSF64356, SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989, CLAT_ADAPTOR_S, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP1S2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56377
Secondary accession number(s): B4DSU4, O95326, Q9H2N6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: August 12, 2020
This is version 189 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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