UniProtKB - P56375 (ACYP2_MOUSE)
Protein
Acylphosphatase-2
Gene
Acyp2
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:3.6.1.7
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 31 | PROSITE-ProRule annotation | 1 | |
Active sitei | 49 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- acylphosphatase activity Source: GO_Central
- identical protein binding Source: MGI
Keywordsi
Molecular function | Hydrolase |
Names & Taxonomyi
Protein namesi | Recommended name: Acylphosphatase-2 (EC:3.6.1.7)Alternative name(s): Acylphosphatase, muscle type isozyme Acylphosphate phosphohydrolase 2 |
Gene namesi | Name:Acyp2 Synonyms:Acyp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1922822, Acyp2 |
Subcellular locationi
Mitochondrion
- mitochondrion Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000158543 | 1 – 106 | Acylphosphatase-2Add BLAST | 106 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 100 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3759 |
EPDi | P56375 |
jPOSTi | P56375 |
PaxDbi | P56375 |
PeptideAtlasi | P56375 |
PRIDEi | P56375 |
PTM databases
iPTMneti | P56375 |
PhosphoSitePlusi | P56375 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000060923, Expressed in muscle of leg and 305 other tissues |
Genevisiblei | P56375, MM |
Interactioni
GO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000074195 |
Miscellaneous databases
RNActi | P56375, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 106 | Acylphosphatase-likePROSITE-ProRule annotationAdd BLAST | 91 |
Sequence similaritiesi
Belongs to the acylphosphatase family.Curated
Phylogenomic databases
eggNOGi | KOG3360, Eukaryota |
GeneTreei | ENSGT00390000011103 |
HOGENOMi | CLU_141932_0_1_1 |
InParanoidi | P56375 |
OMAi | NQVRGWV |
OrthoDBi | 1502266at2759 |
PhylomeDBi | P56375 |
TreeFami | TF300288 |
Family and domain databases
InterProi | View protein in InterPro IPR020456, Acylphosphatase IPR001792, Acylphosphatase-like_dom IPR036046, Acylphosphatase-like_dom_sf IPR017968, Acylphosphatase_CS |
PANTHERi | PTHR10029, PTHR10029, 1 hit |
Pfami | View protein in Pfam PF00708, Acylphosphatase, 1 hit |
PRINTSi | PR00112, ACYLPHPHTASE |
SUPFAMi | SSF54975, SSF54975, 1 hit |
PROSITEi | View protein in PROSITE PS00150, ACYLPHOSPHATASE_1, 1 hit PS00151, ACYLPHOSPHATASE_2, 1 hit PS51160, ACYLPHOSPHATASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P56375-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLGRRLAAM TELLKSVDYE VFGTVQGVCF RMYTEGEAKK RGLVGWVKNT
60 70 80 90 100
SKGTVTGQVQ GPEEKVDAMK SWLSKVGSPS SRIDRADFSN EKTISKLEYS
DFSIRY
Sequence cautioni
The sequence AAH27642 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | G → W in AAH27642 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 22 | F → L in BAC32649 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 63 | E → K in BAC32649 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK046238 mRNA Translation: BAC32649.1 AK009134 mRNA Translation: BAB26095.2 AL732595 Genomic DNA No translation available. AL844147 Genomic DNA No translation available. BC027642 mRNA Translation: AAH27642.1 Different initiation. |
CCDSi | CCDS24507.1 |
RefSeqi | NP_083620.1, NM_029344.3 |
Genome annotation databases
Ensembli | ENSMUST00000074613; ENSMUSP00000074195; ENSMUSG00000060923 |
GeneIDi | 75572 |
KEGGi | mmu:75572 |
UCSCi | uc007ihw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK046238 mRNA Translation: BAC32649.1 AK009134 mRNA Translation: BAB26095.2 AL732595 Genomic DNA No translation available. AL844147 Genomic DNA No translation available. BC027642 mRNA Translation: AAH27642.1 Different initiation. |
CCDSi | CCDS24507.1 |
RefSeqi | NP_083620.1, NM_029344.3 |
3D structure databases
SMRi | P56375 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000074195 |
PTM databases
iPTMneti | P56375 |
PhosphoSitePlusi | P56375 |
Proteomic databases
CPTACi | non-CPTAC-3759 |
EPDi | P56375 |
jPOSTi | P56375 |
PaxDbi | P56375 |
PeptideAtlasi | P56375 |
PRIDEi | P56375 |
Protocols and materials databases
Antibodypediai | 30250, 100 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000074613; ENSMUSP00000074195; ENSMUSG00000060923 |
GeneIDi | 75572 |
KEGGi | mmu:75572 |
UCSCi | uc007ihw.1, mouse |
Organism-specific databases
CTDi | 98 |
MGIi | MGI:1922822, Acyp2 |
Phylogenomic databases
eggNOGi | KOG3360, Eukaryota |
GeneTreei | ENSGT00390000011103 |
HOGENOMi | CLU_141932_0_1_1 |
InParanoidi | P56375 |
OMAi | NQVRGWV |
OrthoDBi | 1502266at2759 |
PhylomeDBi | P56375 |
TreeFami | TF300288 |
Miscellaneous databases
BioGRID-ORCSi | 75572, 1 hit in 17 CRISPR screens |
ChiTaRSi | Acyp2, mouse |
PROi | PR:P56375 |
RNActi | P56375, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000060923, Expressed in muscle of leg and 305 other tissues |
Genevisiblei | P56375, MM |
Family and domain databases
InterProi | View protein in InterPro IPR020456, Acylphosphatase IPR001792, Acylphosphatase-like_dom IPR036046, Acylphosphatase-like_dom_sf IPR017968, Acylphosphatase_CS |
PANTHERi | PTHR10029, PTHR10029, 1 hit |
Pfami | View protein in Pfam PF00708, Acylphosphatase, 1 hit |
PRINTSi | PR00112, ACYLPHPHTASE |
SUPFAMi | SSF54975, SSF54975, 1 hit |
PROSITEi | View protein in PROSITE PS00150, ACYLPHOSPHATASE_1, 1 hit PS00151, ACYLPHOSPHATASE_2, 1 hit PS51160, ACYLPHOSPHATASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACYP2_MOUSE | |
Accessioni | P56375Primary (citable) accession number: P56375 Secondary accession number(s): Q5SPV7, Q8BQX2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families