Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P56373 (P2RX3_HUMAN)

Entry version 166 (07 Oct 2020)
Sequence version 2 (22 Sep 2009)
Previous versions | rss
Add a publicationFeedback
Protein

P2X purinoceptor 3

Gene

P2RX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for ATP that acts as a ligand-gated cation channel (PubMed:27626375). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei172ATPCombined sources1 Publication1
Binding sitei275ATPCombined sources1 Publication1
Binding sitei299ATPCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi63 – 65ATPCombined sources1 Publication3
Nucleotide bindingi279 – 281ATPCombined sources1 Publication3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P56373

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-139853, Elevation of cytosolic Ca2+ levels
R-HSA-418346, Platelet homeostasis

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.7.1.6, the atp-gated p2x receptor cation channel (p2x receptor) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
P2X purinoceptor 3
Short name:
P2X3
Alternative name(s):
ATP receptor
Purinergic receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P2RX3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000109991.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:8534, P2RX3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600843, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P56373

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20Cytoplasmic1 PublicationAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 43Helical; Name=11 PublicationAdd BLAST23
Topological domaini44 – 322Extracellular1 PublicationAdd BLAST279
Transmembranei323 – 341Helical; Name=21 PublicationAdd BLAST19
Topological domaini342 – 397Cytoplasmic1 PublicationAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5024

Open Targets

More...OpenTargetsi		ENSG00000109991

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32863

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P56373, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2998

Drug and drug target database

More...DrugBanki		DB01069, Promethazine

DrugCentral

More...DrugCentrali		P56373

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		480

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		P2RX3

Domain mapping of disease mutations (DMDM)

More...DMDMi		259016295

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001615511 – 397P2X purinoceptor 3Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi107 ↔ 153Combined sources1 Publication
Disulfide bondi116 ↔ 137Combined sources1 Publication
Disulfide bondi122 ↔ 147Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi139N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi170N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi194N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi203 ↔ 213Combined sources1 Publication
Disulfide bondi247 ↔ 256Combined sources1 Publication
Glycosylationi290N-linked (GlcNAc...) asparagineCombined sources1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P56373

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P56373

PeptideAtlas

More...PeptideAtlasi		P56373

PRoteomics IDEntifications database

More...PRIDEi		P56373

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56914

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P56373, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P56373

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P56373

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000109991, Expressed in right testis and 75 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P56373, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P56373, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000109991, Tissue enhanced (heart muscle, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (PubMed:27626375). Functional P2XRs are organized as homomeric and heteromeric trimers (By similarity).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111063, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263314

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P56373

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P56373, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1397
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P56373

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUDE, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214492

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034469_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P56373

KEGG Orthology (KO)

More...KOi		K05217

Identification of Orthologs from Complete Genome Data

More...OMAi		VQGFCPE

Database of Orthologous Groups

More...OrthoDBi		1128763at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P56373

TreeFam database of animal gene trees

More...TreeFami		TF328633

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.490.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003046, P2X3_purnocptor
IPR027309, P2X_extracellular_dom_sf
IPR001429, P2X_purnocptor

The PANTHER Classification System

More...PANTHERi		PTHR10125:SF8, PTHR10125:SF8, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005713, P2X_purinoceptor, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01310, P2X3RECEPTOR
PR01307, P2XRECEPTOR

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00863, P2X, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01212, P2X_RECEPTOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P56373-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNCISDFFTY ETTKSVVVKS WTIGIINRVV QLLIISYFVG WVFLHEKAYQ 
        60         70         80         90        100
VRDTAIESSV VTKVKGSGLY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE 
       110        120        130        140        150
NQMQGFCPES EEKYRCVSDS QCGPERLPGG GILTGRCVNY SSVLRTCEIQ 
       160        170        180        190        200
GWCPTEVDTV ETPIMMEAEN FTIFIKNSIR FPLFNFEKGN LLPNLTARDM 
       210        220        230        240        250
KTCRFHPDKD PFCPILRVGD VVKFAGQDFA KLARTGGVLG IKIGWVCDLD 
       260        270        280        290        300
KAWDQCIPKY SFTRLDSVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA 
       310        320        330        340        350
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA 
       360        370        380        390 
DQYKAKKFEE VNETTLKIAA LTNPVYPSDQ TTAEKQSTDS GAFSIGH
Length:397
Mass (Da):44,289
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CB0081E65748EED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X210A0A087X210_HUMAN
P2X purinoceptor
P2RX3
396Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDR6H0YDR6_HUMAN
P2X purinoceptor 3
P2RX3
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti126R → P in CAA68947 (PubMed:9016352).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034674383A → V1 PublicationCorresponds to variant dbSNP:rs2276038Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y07683 mRNA Translation: CAA68947.1
AB016608 mRNA Translation: BAA76515.1
AP000781 Genomic DNA No translation available.
BC074792 mRNA Translation: AAH74792.1
BC074793 mRNA Translation: AAH74793.1
BC109287 mRNA Translation: AAI09288.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7953.1

NCBI Reference Sequences

More...RefSeqi		NP_002550.2, NM_002559.3
XP_011543371.1, XM_011545069.2
XP_011543372.1, XM_011545070.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263314; ENSP00000263314; ENSG00000109991

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5024

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5024

UCSC genome browser

More...UCSCi		uc001nju.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

P2X receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07683 mRNA Translation: CAA68947.1
AB016608 mRNA Translation: BAA76515.1
AP000781 Genomic DNA No translation available.
BC074792 mRNA Translation: AAH74792.1
BC074793 mRNA Translation: AAH74793.1
BC109287 mRNA Translation: AAI09288.1
CCDSiCCDS7953.1
RefSeqiNP_002550.2, NM_002559.3
XP_011543371.1, XM_011545069.2
XP_011543372.1, XM_011545070.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SVJX-ray2.98A6-364[»]
5SVKX-ray2.77A/B6-364[»]
5SVLX-ray2.90A/B6-364[»]
5SVMX-ray3.09A/B6-364[»]
5SVPX-ray3.30A/B6-364[»]
5SVQX-ray3.25A6-364[»]
5SVRX-ray3.13A6-364[»]
5SVSX-ray4.03A6-364[»]
5SVTX-ray3.79A6-364[»]
5YVEX-ray3.40A6-364[»]
6AH4X-ray3.30A/B/C17-363[»]
6AH5X-ray3.82A/B/C17-363[»]
SMRiP56373
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111063, 1 interactor
STRINGi9606.ENSP00000263314

Chemistry databases

BindingDBiP56373
ChEMBLiCHEMBL2998
DrugBankiDB01069, Promethazine
DrugCentraliP56373
GuidetoPHARMACOLOGYi480

Protein family/group databases

TCDBi1.A.7.1.6, the atp-gated p2x receptor cation channel (p2x receptor) family

PTM databases

GlyGeniP56373, 4 sites
iPTMnetiP56373
PhosphoSitePlusiP56373

Polymorphism and mutation databases

BioMutaiP2RX3
DMDMi259016295

Proteomic databases

MassIVEiP56373
PaxDbiP56373
PeptideAtlasiP56373
PRIDEiP56373
ProteomicsDBi56914

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14096, 235 antibodies

Genome annotation databases

EnsembliENST00000263314; ENSP00000263314; ENSG00000109991
GeneIDi5024
KEGGihsa:5024
UCSCiuc001nju.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5024
DisGeNETi5024
EuPathDBiHostDB:ENSG00000109991.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		P2RX3
HGNCiHGNC:8534, P2RX3
HPAiENSG00000109991, Tissue enhanced (heart muscle, testis)
MIMi600843, gene
neXtProtiNX_P56373
OpenTargetsiENSG00000109991
PharmGKBiPA32863

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUDE, Eukaryota
GeneTreeiENSGT01000000214492
HOGENOMiCLU_034469_8_0_1
InParanoidiP56373
KOiK05217
OMAiVQGFCPE
OrthoDBi1128763at2759
PhylomeDBiP56373
TreeFamiTF328633

Enzyme and pathway databases

PathwayCommonsiP56373
ReactomeiR-HSA-139853, Elevation of cytosolic Ca2+ levels
R-HSA-418346, Platelet homeostasis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5024, 8 hits in 865 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		P2RX3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		P2RX3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5024
PharosiP56373, Tchem

Protein Ontology

More...PROi		PR:P56373
RNActiP56373, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000109991, Expressed in right testis and 75 other tissues
ExpressionAtlasiP56373, baseline and differential
GenevisibleiP56373, HS

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003046, P2X3_purnocptor
IPR027309, P2X_extracellular_dom_sf
IPR001429, P2X_purnocptor
PANTHERiPTHR10125:SF8, PTHR10125:SF8, 1 hit
PIRSFiPIRSF005713, P2X_purinoceptor, 1 hit
PRINTSiPR01310, P2X3RECEPTOR
PR01307, P2XRECEPTOR
TIGRFAMsiTIGR00863, P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212, P2X_RECEPTOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2RX3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56373
Secondary accession number(s): Q6DK37, Q9UQB6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 22, 2009
Last modified: October 7, 2020
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again