P2RX3

Functionⁱ

Receptor for ATP that acts as a ligand-gated cation channel (PubMed:27626375).

Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity).

By similarity1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	172	ATPCombined sources1 Publication	1
Binding siteⁱ	275	ATPCombined sources1 Publication	1
Binding siteⁱ	299	ATPCombined sources1 Publication	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	63 – 65	ATPCombined sources1 Publication		3
Nucleotide bindingⁱ	279 – 281	ATPCombined sources1 Publication		3

GO - Molecular functionⁱ

ATP binding
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.5
  "X-ray structures define human P2X(3) receptor gating cycle and antagonist action."
  Mansoor S.E., Lu W., Oosterheert W., Shekhar M., Tajkhorshid E., Gouaux E.
  Nature 538:66-71(2016) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.77 ANGSTROMS) OF 6-364 IN COMPLEXES WITH ATP AND ATP ANALOG, FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, SUBUNIT, GLYCOSYLATION AT ASN-139; ASN-170; ASN-194 AND ASN-290, DISULFIDE BONDS.
extracellularly ATP-gated cation channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.5
  "X-ray structures define human P2X(3) receptor gating cycle and antagonist action."
  Mansoor S.E., Lu W., Oosterheert W., Shekhar M., Tajkhorshid E., Gouaux E.
  Nature 538:66-71(2016) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.77 ANGSTROMS) OF 6-364 IN COMPLEXES WITH ATP AND ATP ANALOG, FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, SUBUNIT, GLYCOSYLATION AT ASN-139; ASN-170; ASN-194 AND ASN-290, DISULFIDE BONDS.
identical protein binding Source: Ensembl
purinergic nucleotide receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.5
  "X-ray structures define human P2X(3) receptor gating cycle and antagonist action."
  Mansoor S.E., Lu W., Oosterheert W., Shekhar M., Tajkhorshid E., Gouaux E.
  Nature 538:66-71(2016) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.77 ANGSTROMS) OF 6-364 IN COMPLEXES WITH ATP AND ATP ANALOG, FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, SUBUNIT, GLYCOSYLATION AT ASN-139; ASN-170; ASN-194 AND ASN-290, DISULFIDE BONDS.

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

PathwayCommonsⁱ	P56373
Reactomeⁱ	R-HSA-139853, Elevation of cytosolic Ca2+ levels R-HSA-418346, Platelet homeostasis

Protein family/group databases

TCDBⁱ	1.A.7.1.6, the atp-gated p2x receptor cation channel (p2x receptor) family

TCDBⁱ

1.A.7.1.6, the atp-gated p2x receptor cation channel (p2x receptor) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: P2X purinoceptor 3 Short name: P2X3 Alternative name(s): ATP receptor Purinergic receptor
Gene namesⁱ	Name:P2RX3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8534, P2RX3
MIMⁱ	600843, gene
neXtProtⁱ	NX_P56373
VEuPathDBⁱ	HostDB:ENSG00000109991

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 20	Cytoplasmic1 PublicationAdd BLAST	20
Transmembraneⁱ	21 – 43	Helical; Name=11 PublicationAdd BLAST	23
Topological domainⁱ	44 – 322	Extracellular1 PublicationAdd BLAST	279
Transmembraneⁱ	323 – 341	Helical; Name=21 PublicationAdd BLAST	19
Topological domainⁱ	342 – 397	Cytoplasmic1 PublicationAdd BLAST	56

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5024
Open Targets More...OpenTargetsⁱ	ENSG00000109991
PharmGKBⁱ	PA32863

Miscellaneous databases

Pharosⁱ	P56373, Tchem

Pharosⁱ

P56373, Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL2998
Drug and drug target database More...DrugBankⁱ	DB01069, Promethazine
DrugCentral More...DrugCentralⁱ	P56373
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	480

Genetic variation databases

BioMutaⁱ	P2RX3
DMDMⁱ	259016295

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000161551	1 – 397	P2X purinoceptor 3Add BLAST		397

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	107 ↔ 153	Combined sources1 Publication
Disulfide bondⁱ	116 ↔ 137	Combined sources1 Publication
Disulfide bondⁱ	122 ↔ 147	Combined sources1 Publication
Glycosylationⁱ	139	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Glycosylationⁱ	170	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Glycosylationⁱ	194	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Disulfide bondⁱ	203 ↔ 213	Combined sources1 Publication
Disulfide bondⁱ	247 ↔ 256	Combined sources1 Publication
Glycosylationⁱ	290	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MassIVEⁱ	P56373
PaxDbⁱ	P56373
PeptideAtlas More...PeptideAtlasⁱ	P56373
PRIDEⁱ	P56373

PTM databases

GlyGenⁱ	P56373, 4 sites
iPTMnetⁱ	P56373
PhosphoSitePlusⁱ	P56373

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000109991, Expressed in right testis and 75 other tissues
ExpressionAtlasⁱ	P56373, baseline and differential
Genevisibleⁱ	P56373, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000109991, Tissue enhanced (heart muscle, liver, testis)

HPAⁱ

ENSG00000109991, Tissue enhanced (heart muscle, liver, testis)

Interactionⁱ

Subunit structureⁱ

Homotrimer (PubMed:27626375). Functional P2XRs are organized as homomeric and heteromeric trimers (By similarity).

By similarity1 Publication

GO - Molecular functionⁱ

identical protein binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	111063, 1 interactor
STRINGⁱ	9606.ENSP00000263314

Chemistry databases

BindingDBⁱ

P56373

Miscellaneous databases

RNActⁱ	P56373, protein

RNActⁱ

P56373, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	15 – 18	Combined sources	4
Helixⁱ	21 – 40	Combined sources	20
Helixⁱ	41 – 45	Combined sources	5
Turnⁱ	46 – 49	Combined sources	4
Beta strandⁱ	50 – 53	Combined sources	4
Beta strandⁱ	57 – 65	Combined sources	9
Beta strandⁱ	68 – 70	Combined sources	3
Beta strandⁱ	73 – 75	Combined sources	3
Helixⁱ	77 – 80	Combined sources	4
Beta strandⁱ	81 – 83	Combined sources	3
Beta strandⁱ	88 – 108	Combined sources	21
Helixⁱ	112 – 114	Combined sources	3
Helixⁱ	119 – 121	Combined sources	3
Helixⁱ	124 – 126	Combined sources	3
Beta strandⁱ	128 – 143	Combined sources	16
Beta strandⁱ	145 – 154	Combined sources	10
Helixⁱ	166 – 170	Combined sources	5
Beta strandⁱ	172 – 181	Combined sources	10
Turnⁱ	182 – 185	Combined sources	4
Beta strandⁱ	186 – 191	Combined sources	6
Turnⁱ	193 – 195	Combined sources	3
Helixⁱ	197 – 202	Combined sources	6
Turnⁱ	207 – 209	Combined sources	3
Beta strandⁱ	215 – 217	Combined sources	3
Helixⁱ	218 – 224	Combined sources	7
Helixⁱ	229 – 235	Combined sources	7
Beta strandⁱ	237 – 248	Combined sources	12
Helixⁱ	253 – 255	Combined sources	3
Beta strandⁱ	259 – 265	Combined sources	7
Helixⁱ	267 – 270	Combined sources	4
Beta strandⁱ	273 – 275	Combined sources	3
Beta strandⁱ	279 – 287	Combined sources	9
Beta strandⁱ	289 – 291	Combined sources	3
Beta strandⁱ	293 – 316	Combined sources	24
Helixⁱ	318 – 332	Combined sources	15
Helixⁱ	333 – 335	Combined sources	3
Helixⁱ	336 – 345	Combined sources	10
Beta strandⁱ	346 – 348	Combined sources	3
Helixⁱ	350 – 357	Combined sources	8
Beta strandⁱ	358 – 360	Combined sources	3

Show more details

3D structure databases

AlphaFoldDBⁱ	P56373
SMRⁱ	P56373
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	378 – 397	DisorderedSequence analysisAdd BLAST		20

Sequence similaritiesⁱ

Belongs to the P2X receptor family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG502QUDE, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT01020000230351
HOGENOMⁱ	CLU_034469_8_0_1
InParanoidⁱ	P56373
OMAⁱ	CPAEIDD
Database of Orthologous Groups More...OrthoDBⁱ	1128763at2759
PhylomeDBⁱ	P56373
TreeFamⁱ	TF328633

Family and domain databases

Gene3Dⁱ	2.60.490.10, 1 hit
InterProⁱ	View protein in InterPro IPR003046, P2X3_purnocptor IPR027309, P2X_extracellular_dom_sf IPR001429, P2X_purnocptor
PANTHERⁱ	PTHR10125:SF8, PTHR10125:SF8, 1 hit
PIRSFⁱ	PIRSF005713, P2X_purinoceptor, 1 hit
PRINTSⁱ	PR01310, P2X3RECEPTOR PR01307, P2XRECEPTOR
TIGRFAMsⁱ	TIGR00863, P2X, 1 hit
PROSITEⁱ	View protein in PROSITE PS01212, P2X_RECEPTOR, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P56373-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNCISDFFTY ETTKSVVVKS WTIGIINRVV QLLIISYFVG WVFLHEKAYQ 
        60         70         80         90        100
VRDTAIESSV VTKVKGSGLY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE 
       110        120        130        140        150
NQMQGFCPES EEKYRCVSDS QCGPERLPGG GILTGRCVNY SSVLRTCEIQ 
       160        170        180        190        200
GWCPTEVDTV ETPIMMEAEN FTIFIKNSIR FPLFNFEKGN LLPNLTARDM 
       210        220        230        240        250
KTCRFHPDKD PFCPILRVGD VVKFAGQDFA KLARTGGVLG IKIGWVCDLD 
       260        270        280        290        300
KAWDQCIPKY SFTRLDSVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA 
       310        320        330        340        350
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA 
       360        370        380        390 
DQYKAKKFEE VNETTLKIAA LTNPVYPSDQ TTAEKQSTDS GAFSIGH

Length:397

Mass (Da):44,289

Last modified:September 22, 2009 - v2

Checksum:ⁱ3CB0081E65748EED

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0YDR6	H0YDR6_HUMAN		P2X purinoceptor 3 P2X purinoceptor 3	P2RX3	50	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	126	R → P in CAA68947 (PubMed:9016352).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034674	383	A → V1 PublicationCorresponds to variant dbSNP:rs2276038Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y07683 mRNA Translation: CAA68947.1 AB016608 mRNA Translation: BAA76515.1 AP000781 Genomic DNA No translation available. BC074792 mRNA Translation: AAH74792.1 BC074793 mRNA Translation: AAH74793.1 BC109287 mRNA Translation: AAI09288.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7953.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002550.2, NM_002559.3 XP_011543371.1, XM_011545069.2 XP_011543372.1, XM_011545070.2

Genome annotation databases

Ensemblⁱ	ENST00000263314.3; ENSP00000263314.2; ENSG00000109991.10
GeneIDⁱ	5024
KEGGⁱ	hsa:5024
MANE-Selectⁱ	ENST00000263314.3; ENSP00000263314.2; NM_002559.5; NP_002550.2
UCSC genome browser More...UCSCⁱ	uc001nju.4, human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P56373	P2X purinoceptor 3 (Fragment)		HUMAN		50	UniRef100_P56373
+1

Protein	Similar proteins		Species	Score	Length	Source
P56373	P2X purinoceptor 3 (Fragment)		HUMAN		50	UniRef90_P56373
P2X purinoceptor		RHIRO		398
P2X purinoceptor		PONAB		397
P2X purinoceptor		MACMU		397
P2X purinoceptor		CERAT		397
+24

Protein	Similar proteins		Species	Score	Length	Source
P56373	P2X purinoceptor 3		MOUSE		397	UniRef50_Q3UR32
P2X purinoceptor		MUSSI		397
Purinergic receptor P2X 3		PONAB		469
P2X purinoceptor		JACJA		397
P2X purinoceptor		PERMB		397
+72

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

P2X receptor entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y07683 mRNA Translation: CAA68947.1 AB016608 mRNA Translation: BAA76515.1 AP000781 Genomic DNA No translation available. BC074792 mRNA Translation: AAH74792.1 BC074793 mRNA Translation: AAH74793.1 BC109287 mRNA Translation: AAI09288.1
CCDSⁱ	CCDS7953.1
RefSeqⁱ	NP_002550.2, NM_002559.3 XP_011543371.1, XM_011545069.2 XP_011543372.1, XM_011545070.2

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5SVJ	X-ray	2.98	A	6-364	[»]
	5SVK	X-ray	2.77	A/B	6-364	[»]
	5SVL	X-ray	2.90	A/B	6-364	[»]
	5SVM	X-ray	3.09	A/B	6-364	[»]
	5SVP	X-ray	3.30	A/B	6-364	[»]
	5SVQ	X-ray	3.25	A	6-364	[»]
	5SVR	X-ray	3.13	A	6-364	[»]
	5SVS	X-ray	4.03	A	6-364	[»]
	5SVT	X-ray	3.79	A	6-364	[»]
	5YVE	X-ray	3.40	A	6-364	[»]
	6AH4	X-ray	3.30	A/B/C	17-363	[»]
	6AH5	X-ray	3.82	A/B/C	17-363	[»]
AlphaFoldDBⁱ	P56373
SMRⁱ	P56373
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	111063, 1 interactor
STRINGⁱ	9606.ENSP00000263314

Chemistry databases

BindingDBⁱ	P56373
ChEMBLⁱ	CHEMBL2998
DrugBankⁱ	DB01069, Promethazine
DrugCentralⁱ	P56373
GuidetoPHARMACOLOGYⁱ	480

Protein family/group databases

TCDBⁱ	1.A.7.1.6, the atp-gated p2x receptor cation channel (p2x receptor) family

TCDBⁱ

1.A.7.1.6, the atp-gated p2x receptor cation channel (p2x receptor) family

PTM databases

GlyGenⁱ	P56373, 4 sites
iPTMnetⁱ	P56373
PhosphoSitePlusⁱ	P56373

Genetic variation databases

BioMutaⁱ	P2RX3
DMDMⁱ	259016295

Proteomic databases

MassIVEⁱ	P56373
PaxDbⁱ	P56373
PeptideAtlasⁱ	P56373
PRIDEⁱ	P56373

Protocols and materials databases

Antibodypediaⁱ	14096, 249 antibodies from 31 providers
The DNASU plasmid repository More...DNASUⁱ	5024

Genome annotation databases

Ensemblⁱ	ENST00000263314.3; ENSP00000263314.2; ENSG00000109991.10
GeneIDⁱ	5024
KEGGⁱ	hsa:5024
MANE-Selectⁱ	ENST00000263314.3; ENSP00000263314.2; NM_002559.5; NP_002550.2
UCSCⁱ	uc001nju.4, human

Organism-specific databases

CTDⁱ	5024
DisGeNETⁱ	5024
GeneCardsⁱ	P2RX3
HGNCⁱ	HGNC:8534, P2RX3
HPAⁱ	ENSG00000109991, Tissue enhanced (heart muscle, liver, testis)
MIMⁱ	600843, gene
neXtProtⁱ	NX_P56373
OpenTargetsⁱ	ENSG00000109991
PharmGKBⁱ	PA32863
VEuPathDBⁱ	HostDB:ENSG00000109991
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502QUDE, Eukaryota
GeneTreeⁱ	ENSGT01020000230351
HOGENOMⁱ	CLU_034469_8_0_1
InParanoidⁱ	P56373
OMAⁱ	CPAEIDD
OrthoDBⁱ	1128763at2759
PhylomeDBⁱ	P56373
TreeFamⁱ	TF328633

Enzyme and pathway databases

PathwayCommonsⁱ	P56373
Reactomeⁱ	R-HSA-139853, Elevation of cytosolic Ca2+ levels R-HSA-418346, Platelet homeostasis

Miscellaneous databases

BioGRID-ORCSⁱ	5024, 17 hits in 1065 CRISPR screens
ChiTaRSⁱ	P2RX3, human
GeneWikiⁱ	P2RX3
GenomeRNAiⁱ	5024
Pharosⁱ	P56373, Tchem
Protein Ontology More...PROⁱ	PR:P56373
RNActⁱ	P56373, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000109991, Expressed in right testis and 75 other tissues
ExpressionAtlasⁱ	P56373, baseline and differential
Genevisibleⁱ	P56373, HS

Family and domain databases

Gene3Dⁱ	2.60.490.10, 1 hit
InterProⁱ	View protein in InterPro IPR003046, P2X3_purnocptor IPR027309, P2X_extracellular_dom_sf IPR001429, P2X_purnocptor
PANTHERⁱ	PTHR10125:SF8, PTHR10125:SF8, 1 hit
PIRSFⁱ	PIRSF005713, P2X_purinoceptor, 1 hit
PRINTSⁱ	PR01310, P2X3RECEPTOR PR01307, P2XRECEPTOR
TIGRFAMsⁱ	TIGR00863, P2X, 1 hit
PROSITEⁱ	View protein in PROSITE PS01212, P2X_RECEPTOR, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	P2RX3_HUMAN
Accessionⁱ	P56373Primary (citable) accession number: P56373 Secondary accession number(s): Q6DK37, Q9UQB6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	September 22, 2009
	Last modified:	May 25, 2022
	This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - P56373 (P2RX3_HUMAN)

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P2X purinoceptor 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ