Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

P2X purinoceptor 3

Gene

P2RX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated cation channel (PubMed:27626375). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei172ATPCombined sources1 Publication1
Binding sitei275ATPCombined sources1 Publication1
Binding sitei299ATPCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 65ATPCombined sources1 Publication3
Nucleotide bindingi279 – 281ATPCombined sources1 Publication3

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • ATP-gated ion channel activity Source: GO_Central
  • extracellularly ATP-gated cation channel activity Source: UniProtKB
  • purinergic nucleotide receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-418346 Platelet homeostasis

Protein family/group databases

TCDBi1.A.7.1.6 the atp-gated p2x receptor cation channel (p2x receptor) family

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 3
Short name:
P2X3
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000109991.8
HGNCiHGNC:8534 P2RX3
MIMi600843 gene
neXtProtiNX_P56373

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20Cytoplasmic1 PublicationAdd BLAST20
Transmembranei21 – 43Helical; Name=11 PublicationAdd BLAST23
Topological domaini44 – 322Extracellular1 PublicationAdd BLAST279
Transmembranei323 – 341Helical; Name=21 PublicationAdd BLAST19
Topological domaini342 – 397Cytoplasmic1 PublicationAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5024
OpenTargetsiENSG00000109991
PharmGKBiPA32863

Chemistry databases

ChEMBLiCHEMBL2998
GuidetoPHARMACOLOGYi480

Polymorphism and mutation databases

BioMutaiP2RX3
DMDMi259016295

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615511 – 397P2X purinoceptor 3Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi107 ↔ 153Combined sources1 Publication
Disulfide bondi116 ↔ 137Combined sources1 Publication
Disulfide bondi122 ↔ 147Combined sources1 Publication
Glycosylationi139N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi170N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi194N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi203 ↔ 213Combined sources1 Publication
Disulfide bondi247 ↔ 256Combined sources1 Publication
Glycosylationi290N-linked (GlcNAc...) asparagineCombined sources1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP56373
PeptideAtlasiP56373
PRIDEiP56373
ProteomicsDBi56914

PTM databases

iPTMnetiP56373
PhosphoSitePlusiP56373

Expressioni

Gene expression databases

BgeeiENSG00000109991 Expressed in 50 organ(s), highest expression level in right testis
CleanExiHS_P2RX3
ExpressionAtlasiP56373 baseline and differential
GenevisibleiP56373 HS

Organism-specific databases

HPAiHPA057776

Interactioni

Subunit structurei

Homotrimer (PubMed:27626375). Functional P2XRs are organized as homomeric and heteromeric trimers (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000263314

Chemistry databases

BindingDBiP56373

Structurei

Secondary structure

1397
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP56373
SMRiP56373
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiP56373
KOiK05217
OMAiGWCPAEI
OrthoDBiEOG091G0A2U
PhylomeDBiP56373
TreeFamiTF328633

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003046 P2X3_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF8 PTHR10125:SF8, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01310 P2X3RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P56373-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNCISDFFTY ETTKSVVVKS WTIGIINRVV QLLIISYFVG WVFLHEKAYQ
60 70 80 90 100
VRDTAIESSV VTKVKGSGLY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE
110 120 130 140 150
NQMQGFCPES EEKYRCVSDS QCGPERLPGG GILTGRCVNY SSVLRTCEIQ
160 170 180 190 200
GWCPTEVDTV ETPIMMEAEN FTIFIKNSIR FPLFNFEKGN LLPNLTARDM
210 220 230 240 250
KTCRFHPDKD PFCPILRVGD VVKFAGQDFA KLARTGGVLG IKIGWVCDLD
260 270 280 290 300
KAWDQCIPKY SFTRLDSVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA
310 320 330 340 350
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA
360 370 380 390
DQYKAKKFEE VNETTLKIAA LTNPVYPSDQ TTAEKQSTDS GAFSIGH
Length:397
Mass (Da):44,289
Last modified:September 22, 2009 - v2
Checksum:i3CB0081E65748EED
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X210A0A087X210_HUMAN
p2X purinoceptor
P2RX3
396Annotation score:
H0YDR6H0YDR6_HUMAN
P2X purinoceptor 3
P2RX3
50Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126R → P in CAA68947 (PubMed:9016352).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034674383A → V1 PublicationCorresponds to variant dbSNP:rs2276038Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07683 mRNA Translation: CAA68947.1
AB016608 mRNA Translation: BAA76515.1
AP000781 Genomic DNA No translation available.
BC074792 mRNA Translation: AAH74792.1
BC074793 mRNA Translation: AAH74793.1
BC109287 mRNA Translation: AAI09288.1
CCDSiCCDS7953.1
RefSeqiNP_002550.2, NM_002559.3
XP_011543371.1, XM_011545069.2
XP_011543372.1, XM_011545070.2
UniGeneiHs.146738
Hs.269363

Genome annotation databases

EnsembliENST00000263314; ENSP00000263314; ENSG00000109991
GeneIDi5024
KEGGihsa:5024
UCSCiuc001nju.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

P2X receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07683 mRNA Translation: CAA68947.1
AB016608 mRNA Translation: BAA76515.1
AP000781 Genomic DNA No translation available.
BC074792 mRNA Translation: AAH74792.1
BC074793 mRNA Translation: AAH74793.1
BC109287 mRNA Translation: AAI09288.1
CCDSiCCDS7953.1
RefSeqiNP_002550.2, NM_002559.3
XP_011543371.1, XM_011545069.2
XP_011543372.1, XM_011545070.2
UniGeneiHs.146738
Hs.269363

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SVJX-ray2.98A6-364[»]
5SVKX-ray2.77A/B6-364[»]
5SVLX-ray2.90A/B6-364[»]
5SVMX-ray3.09A/B6-364[»]
5SVPX-ray3.30A/B6-364[»]
5SVQX-ray3.25A6-364[»]
5SVRX-ray3.13A6-364[»]
5SVSX-ray4.03A6-364[»]
5SVTX-ray3.79A6-364[»]
5YVEX-ray3.40A6-364[»]
ProteinModelPortaliP56373
SMRiP56373
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263314

Chemistry databases

BindingDBiP56373
ChEMBLiCHEMBL2998
GuidetoPHARMACOLOGYi480

Protein family/group databases

TCDBi1.A.7.1.6 the atp-gated p2x receptor cation channel (p2x receptor) family

PTM databases

iPTMnetiP56373
PhosphoSitePlusiP56373

Polymorphism and mutation databases

BioMutaiP2RX3
DMDMi259016295

Proteomic databases

PaxDbiP56373
PeptideAtlasiP56373
PRIDEiP56373
ProteomicsDBi56914

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263314; ENSP00000263314; ENSG00000109991
GeneIDi5024
KEGGihsa:5024
UCSCiuc001nju.4 human

Organism-specific databases

CTDi5024
DisGeNETi5024
EuPathDBiHostDB:ENSG00000109991.8
GeneCardsiP2RX3
H-InvDBiHIX0035814
HGNCiHGNC:8534 P2RX3
HPAiHPA057776
MIMi600843 gene
neXtProtiNX_P56373
OpenTargetsiENSG00000109991
PharmGKBiPA32863
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiP56373
KOiK05217
OMAiGWCPAEI
OrthoDBiEOG091G0A2U
PhylomeDBiP56373
TreeFamiTF328633

Enzyme and pathway databases

ReactomeiR-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-418346 Platelet homeostasis

Miscellaneous databases

ChiTaRSiP2RX3 human
GeneWikiiP2RX3
GenomeRNAii5024
PROiPR:P56373
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109991 Expressed in 50 organ(s), highest expression level in right testis
CleanExiHS_P2RX3
ExpressionAtlasiP56373 baseline and differential
GenevisibleiP56373 HS

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003046 P2X3_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF8 PTHR10125:SF8, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01310 P2X3RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP2RX3_HUMAN
AccessioniPrimary (citable) accession number: P56373
Secondary accession number(s): Q6DK37, Q9UQB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 22, 2009
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again